A5046736670- Cardiac Fibrosis and Remodeling
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Cardiomyopathy and Myosin Studies
- Sex and Gender in Healthcare
- RNA Research and Splicing
- Congenital heart defects research
- Adipose Tissue and Metabolism
- Tissue Engineering and Regenerative Medicine
- Menopause: Health Impacts and Treatments
- Mitochondrial Function and Pathology
- Artificial Intelligence in Healthcare and Education
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Cardiac Arrest and Resuscitation
- Cardiovascular Effects of Exercise
- Lipoproteins and Cardiovascular Health
- Kruppel-like factors research
- Cardiovascular Function and Risk Factors
- Metabolomics and Mass Spectrometry Studies
- Heart Failure Treatment and Management
- Cardiovascular Issues in Pregnancy
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Valve Diseases and Treatments
University of Iceland
2018-2025
Charité - Universitätsmedizin Berlin
2011-2020
German Centre for Cardiovascular Research
2014-2020
Humboldt-Universität zu Berlin
2017-2020
Freie Universität Berlin
2017-2020
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018
Czech Academy of Sciences, Institute of Physiology
2012
University of Lucknow
2012
Medical University of Warsaw
2012
Leiden University Medical Center
2012
Background— Hemodynamic load regulates myocardial function and gene expression. We tested the hypothesis that afterload preload, despite similar average load, result in different phenotypes. Methods Results— Afterload preload were compared mice with transverse aortic constriction (TAC) aortocaval shunt (shunt). Compared sham mice, 6 hours after surgery, systolic wall stress (afterload) was increased TAC (+40%; P <0.05), diastolic (preload) (+277%; <0.05) (+74%; mean total similarly...
We investigated sex differences and the role of estrogen receptor-β (ERβ) on myocardial hypertrophy in a mouse model pressure overload. performed transverse aortic constriction (TAC) or sham surgery male female wild-type (WT) ERβ knockout (ERβ −/− ) mice. All mice were characterized by echocardiography hemodynamic measurements killed 9 wk after surgery. Left ventricular (LV) samples analyzed microarray profiling, real-time RT-PCR, histology. After wk, WT males showed more heart failure signs...
Aims Dilated cardiomyopathy (DCM) is an important cause of heart failure with a strong familial component. We performed exome-wide array-based association study (EWAS) to assess the contribution missense variants sporadic DCM. Methods and results 116,855 single nucleotide (SNVs) were analyzed in 2796 DCM patients 6877 control subjects from 6 populations European ancestry. confirmed two previously identified associations SNVs BAG3 ZBTB17 discovered six novel DCM-associated loci...
Diabetic cardiomyopathy (DbCM) is a major complication in type-1 diabetes, accompanied by altered cardiac energetics, impaired mitochondrial function, and oxidative stress. Previous studies indicate that diabetes associated with increased expression of KLF5 (Krüppel-like factor-5) PPARα (peroxisome proliferator-activated receptor) regulate lipid metabolism.
The purpose of this study was to test whether adaptive or maladaptive remodeling is associated with survival in women and men after aortic valve replacement (AVR). Women isolated stenosis (AS) develop more concentric left ventricular hypertrophy (LVH) than similar disease states. We recently reported less up-regulation profibrotic genes at AVR faster LVH regression post-operatively men, suggesting that there are sex differences the adaptation pressure overload its regression. cohort included...
The ethical and societal implications of artificial intelligence systems raise concerns. In this article, we outline a novel process based on applied ethics, namely, Z-Inspection <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> , to assess if an AI system is trustworthy. We use the definition trustworthy given by high-level European Commission's expert group AI. general inspection that can be variety domains where are used, such as...
Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a leading cause systolic heart failure.
Purpose Aging has severe implications for tissue damage and is a major risk factor disease. However, the effects of aging on cardiac extracellular matrix (ECM) components in individuals free cardiovascular disease are incompletely understood. We aimed at characterization ECM proteins heart men women. Experimental design Left ventricular (LV) samples nondiseased human hearts technically unusable transplantation obtained from general organ donors ( n = 31; age 17–68 years; 48% women) were used...
Oestrogen receptor alpha (ERα) and beta (ERβ) are involved in the regulation of pathological myocardial hypertrophy (MH). We hypothesize that both ER also physiological MH. Therefore, we investigated role exercise-induced MH loss-of-function models studied potential mechanisms action. performed 1 8 weeks voluntary cage wheel running (VCR) with male female C57BL/6J wild-type (WT), ERα- ERβ-deleted mice. In line other studies, WT mice ran more than males (P ≤ 0.001). After VCR, sexes showed an...
Impairment of skeletal muscle function has been associated with changes in ovarian hormones, especially estradiol. To elucidate mechanisms estradiol on strength, the hormone's effects phosphorylation myosin regulatory light chain (pRLC) and contractility were investigated, hypothesizing an estradiol-specific beneficial impact. In a cell line, C 2 12 , pRLC was increased by 17β-estradiol (E ) concentration-dependent manner. muscles C57BL/6 mice that E deficient via ovariectomy (OVX), lower...
Availability of oxygen and nutrients in the coronary circulation is a crucial determinant cardiac performance. Nutrient composition blood may significantly vary specific physiological pathological conditions, for example, administration special diets, long-term starvation, physical exercise or diabetes. Quantitative analysis metabolism from systems biology perspective help to better understanding relationship between nutrient supply efficiency metabolic processes required an adequate output....
Cardiac hypertrophy, the adaptive response of heart to overload, is a major risk factor for failure and sudden death. Estrogen (E2) estrogen receptor beta (ERbeta) offer protection against hypertrophy in transition failure. However, underlying pathways remain incompletely defined. We employed publicly available microarray dataset female wild-type (WT) ERbeta knockout (BERKO) mice subjected pressure overload-induced perform systematic investigation mechanisms involved conferred by E2/ERbeta...
Artificial Intelligence (AI) has the potential to greatly improve delivery of healthcare and other services that advance population health wellbeing. However, use AI in also brings risks may cause unintended harm. To guide future developments AI, High-Level Expert Group on set up by European Commission (EC), recently published ethics guidelines for what it terms “trustworthy” AI. These are aimed at a variety stakeholders, especially guiding practitioners toward more ethical robust...
This article's main contributions are twofold: 1) to demonstrate how apply the general European Union's High-Level Expert Group's (EU HLEG) guidelines for trustworthy AI in practice domain of healthcare and 2) investigate research question what does "trustworthy AI" mean at time COVID-19 pandemic. To this end, we present results a post-hoc self-assessment evaluate trustworthiness an system predicting multiregional score conveying degree lung compromise patients, developed verified by...