A5066161857- Pharmacological Effects and Assays
- Mental Health and Psychiatry
- Health Sciences Research and Education
- Ethics in Clinical Research
- Cardiovascular and exercise physiology
- Artificial Intelligence in Healthcare and Education
- Meta-analysis and systematic reviews
- Health and Medical Research Impacts
- Primary Care and Health Outcomes
- Hormonal and reproductive studies
- Genomics and Rare Diseases
- COVID-19 Digital Contact Tracing
- Radiomics and Machine Learning in Medical Imaging
- Disaster Response and Management
- Blood Pressure and Hypertension Studies
- Helicobacter pylori-related gastroenterology studies
- Health Promotion and Cardiovascular Prevention
- Digital Mental Health Interventions
- Obesity and Health Practices
- Healthcare cost, quality, practices
- Healthcare Systems and Technology
- Exercise and Physiological Responses
- Cutaneous Melanoma Detection and Management
- Microscopic Colitis
- Sports Performance and Training
University of Copenhagen
2018-2023
Deakin University
2020-2023
Bispebjerg Hospital
2013-2015
An abundant and growing supply of digital health applications (apps) exists in the commercial tech-sector, which can be bewildering for clinicians, patients, payers. A challenge care system is therefore to facilitate identification safe effective apps practitioners patients generate most benefit as well guide payer coverage decisions. Nearly all developed countries are attempting define policy frameworks improve decision-making, patient care, outcomes this context. This study compares...
This paper documents how an ethically aligned co-design methodology ensures trustworthiness in the early design phase of artificial intelligence (AI) system component for healthcare. The explains decisions made by deep learning networks analyzing images skin lesions. trustworthy AI developed here used a holistic approach rather than static ethical checklist and required multidisciplinary team experts working with designers their managers. Ethical, legal, technical issues potentially arising...
Artificial Intelligence (AI) has the potential to greatly improve delivery of healthcare and other services that advance population health wellbeing. However, use AI in also brings risks may cause unintended harm. To guide future developments AI, High-Level Expert Group on set up by European Commission (EC), recently published ethics guidelines for what it terms “trustworthy” AI. These are aimed at a variety stakeholders, especially guiding practitioners toward more ethical robust...
<h3>Synopsis</h3> In a cohort of middle-aged and elderly Australians, we found that long-term statin use was associated with higher risk glaucoma onset. As to subtypes statins, the increased only in rosuvastatin users. <h3>Purpose</h3> To investigate relationship between onset 10-year longitudinal study. <h3>Methods</h3> This nested case–control study based on data from large-scale Australians aged over 45 years old. Medication exposure identified by claims records Pharmaceutical Benefits...
The study was a randomized placebo-controlled trial investigating mechanisms by which chronic β 2 -adrenergic stimulation enhances muscle force and power output during maximal cycle ergometer exercise in young men. Eighteen trained men were assigned to an experimental group [oral terbutaline 5 mg/30 kg body weight (bw) twice daily (TER); n = 9] or control [placebo (PLA); for 4-wk intervention. No changes observed with the intervention PLA. Isometric of quadriceps increased ( P ≤ 0.01) 97 ±...
The challenges facing the evidence-based medicine (EBM) movement are well documented.1 2 Yet, problems early-career and mid-career researchers (EMCRs) working in ecosystem of EBM have not been articulated. coming together a cohort EMCRs from across globe enabled this articulation.3 2019 EBMLive conference (see box 1) provided space for to discuss problems, exchange ideas create list potential solutions. This article outlines four key faced by their solutions 2). Box 1 ### Conference The...
The present study investigated the influence of exercise and dehydration on urine concentrations salbutamol after inhalation that maximal permitted (1600 µg) 2015 World Anti-Doping Agency (WADA) prohibited list. Thirteen healthy males participated in study. Urine were measured during three conditions: (EX), exercise+dehydration (EXD), rest (R). Exercise consisted 75 min cycling at 60% VO2max a 20-km time-trial. Fluid intake was 2300, 270, 1100 mL EX, EXD, R, respectively. samples collected...
People are increasingly able to generate their own health data through new technologies such as wearables and online symptom checkers. However, generating is one thing, interpreting them another. General practitioners (GPs) likely be the first help with interpretations. Policymakers in European Union investing heavily infrastructures provide GPs access patient measurements. But there may a disconnect between policy ambitions everyday practices of GPs. To investigate this, we conducted...
In three days at the beginning of COVID-19 pandemic, Copenhagen Emergency Medical Services developed a digital diagnostic device. The purpose was to assess and triage potential symptoms reduce number calls public health-care helplines. device used almost 150,000 times in few weeks described by politicians administrators as solution success. However, high usage cannot serve sole criterion What might be adequate criteria? And should for citizens default considered low risk?This paper reflects...
Abstract In contemporary policy discourses, data are presented as key assets for improving health‐care quality: policymakers want health care to become ‘data driven’. this article, we focus on a particular example of ambition, namely new Danish national quality development program general practitioners (GPs) where doctors placed in so‐called ‘clusters’. these clusters, GPs obliged assess their own and colleagues’ clinical with derived from clinics—using comparisons, averages benchmarks....
<h3>Objectives</h3> A problem with the approach of Evidence-based Medicine (EBM) is current ability to only reduce but not prevent overdiagnosis. Overdiagnosis broadly defined as 'making people patients unnecessarily, by identifying problems that were never going cause harm or medicalising ordinary life experiences through expanded definitions diseases'. One aspect overdiagnosis <i>overdefinition</i>, such lowering threshold for treatment a risk factor. example UK's National Institute Health...
<h3></h3> The concept of Evidence-Based Medicine (EBM) does not give clinicians all the answers on how to diminish and prevent overdiagnosis. quaternary prevention defined as an action taken protect persons from medical interventions that are likely cause more harm than good, might be a tool some extent can help with task diminishing preventing However, EBM, goal overdiagnosis interrelated? answer this question will debated using three cases in setting primary, secondary tertiary prevention....
<h3>Objectives</h3> While the definition and importance of phenomenon overdiagnosis have been increasingly debated, underdiagnosis has not. This is despite being less defined in literature evidence-based medicine (EBM) than overdiagnosis. The term used more 2800 scientific papers since 1960s. With growing awareness overdiagnosis, use as well, often a counterargument to Yet, what underdiagnosis? And how it related overdiagnosis? We present preliminary results conceptual investigation...
<h3>Objectives</h3> The increasing awareness and research in overdiagnosis may change the concept itself. This can be for better by providing new insights more nuanced rich investigations. It also worse, turning into theoretical emptiness, meaning widening a to an extent of which it no longer describes intended, specific phenomenon. One example such, is stress, various phenomena within multiple disciplines: from psychology social care everyday life. Is drifting same way? Scholars highlight...
<h3>Objectives</h3> Idiopathic bile acid diarrhea (I-BAD) is a chronic condition involving debilitating for some patients. Yet, the true prevalence shrouded in uncertainty. It often stated that I-BAD er grossly underdiagnosed and could possibly involve 1-2% of general population. The literature within field claims about 1/3 predominant irritable bowel syndrome cases are fact misdiagnosed conditions I-BAD. If this case, can have significant, large-scale implications; from additional demands...
<h3>Objectives</h3> With the ongoing practice of datafication health, ordinary citizens are increasingly able to generate their own health data through new technologies such as wearables and online symptom checkers. However, generating is one thing, interpreting them another. General practitioners (GPs) likely be first help with interpretations. How do GPs describe responses patient-generated data? Policymakers in European Union investing heavily infrastructures facilitate upload patient...
<h3>Objectives</h3> In many healthcare systems, policymakers wish to transform everyday practices and ensure higher quality through digitisation datafication. Digital health technologies, such as digital administrative systems apps, are increasingly introduced support general practitioners (GPs) empower patients. However, initiative can result in unintended outcomes, overdiagnosis, errors wasted resources. We investigated a particular example of the political ambition make 'data driven',...
<h3>Objectives</h3> Many individual drivers for overdiagnosis have been identified. Out of those, the economical one has considered strongest with global market pharmaceuticals now valued at 1.000 billion U.S. dollars and is expected to grow 1.300 in 2020. Despite common awareness above, studies so far lack a more coherent approach explaining structures dynamics society that facilitate rather than examining its single driver alone. The following study offers comprehensive explanation...
<h3>Justification and interest of the workshop</h3> A challenge with approach Evidence-based Medicine (EBM) is current ability to reduce but not prevent overdiagnosis. Three different examples this will be introduced: <h3>Risk factors</h3> The case UK's National Institute for Health Care Excellence updated draft guidance diagnosis management hypertension in adults. evidence based increase However, do principles EBM any increased health risk become a disease as long it supported by positive...