Objective: The objective of this study was to investigate the psychosocial consequences receiving false-positive colorectal cancer (CRC) screening results, following a positive immunochemical faecal occult blood test. Design, setting, and subjects: We conducted qualitative with four semi-structured focus group interviews 16 participants aged 50-74, all whom had received result in national Danish CRC programme. selected, recruited, grouped ensure maximum variation, enable level confidence...

Lung cancer CT screening can reduce lung mortality, but high false-positive rates may cause adverse psychosocial consequences. The aim was to analyse the consequences of using screening-specific questionnaire, Consequences Screening in Cancer (COS-LC).This study a matched cohort study, nested randomised Danish Trial (DLCST).Our included all 130 participants DLCST with positive results rounds 2-5, who had completed COS-LC questionnaire. Participants were split into true-positive and group...

BackgroundParticipation in lung cancer CT-screening can be associated with a need for follow-up procedures. The screening and waiting test results introduce the risk of experiencing psychosocial consequences. Therefore, aims this study were: 1) To investigate if consequences changed from before an annual round to three-month CT-scan participants positive result.2) potential differences between false positives (FP) true (TP). FP were defined as those where was not confirmed TP it...

Objectives We investigated if psychosocial status, sociodemographics and smoking status affected non-attendance in the control group randomised Danish Lung Cancer Screening Trial (DLCST). Design setting This study was an observational nested DLCST. Due to large second screening round we made additional effort collect questionnaire data from non-attenders this third round. used a condition-specific assess status. analysed differences preceding rounds between attenders multivariable linear...

Abstract Background Harms of colorectal cancer (CRC) screening include psychosocial consequences. We have not identified studies using a participant-relevant questionnaire with adequate measurement properties to investigate these harms. However, Brodersen et al. previously developed core consequences (COS) for use in life-threatening diseases. Therefore, the objectives were: (1) To content validity COS CRC setting and case gaps coverage (2) generate new items themes (3) test possibly...

Psychosocial consequences of colorectal cancer (CRC) screening can arise anywhere in the cascade. Previous studies have investigated participating CRC screening; however, we not identified any investigating psychosocial receiving invitation. Therefore, objective this study was to investigate invitation screening.The a longitudinal performed Region Zealand, Denmark. Participants included were random sample 1000 invitees and control persons, invited screening, matched 1:1 design on sex, age...

Objectives To investigate the psychosocial consequences of receiving a false-positive (no abnormalities) result or being diagnosed with polyps compared negative in colorectal cancer (CRC) screening programme. Design and setting This was longitudinal study nested roll-out Danish CRC programme that targets all individuals aged 50–74 years. Participants In inclusion period (April–September 2017), positive screenees (n=1854) were consecutively enrolled matched 2:1:1 on sex, age (±2 years),...

<h3></h3> Disease definitions and treatment thresholds are often based on dichotomisation of continuous variables. Examples these dilemmas the definition hypertension continuum pathologies in polyps colorectal cancer (CRC) screening. Continuous variables a clinical dilemma since they make it difficult to determine when diagnose intervene. Dichotomisation requires per threshold which results an epidemiological dilemma: if is set too low, many people overdiagnosed overtreated, whereas high,...

<h3>Background</h3> Screening for life-threatening diseases has potential benefits and harms. In screening colorectal cancer (CRC) some harms are the negative psychosocial consequences of being diagnosed with polyps or receiving a false-positive result. 2014 national CRC programme was implemented in Denmark, using an immunochemical faecal occult blood test (iFOBT) as method targeting all citizens aged 50–74. implementation period (2014–2017) were invited to participate randomised design....

<h3>Objectives</h3> Harms of screening are generally not well reported. colorectal cancer (CRC) may include negative psychosocial consequences from the attention being drawn to disease through invitation, procedure itself and fear result. Hence, it is important measure before after invitation screening, at screening. Moreover, measurement in settings should be performed using questionnaires with high content validity adequate properties. Despite this fact, few CRC studies investigating have...

<h3>Justification and interest of the workshop</h3> A challenge with approach Evidence-based Medicine (EBM) is current ability to reduce but not prevent overdiagnosis. Three different examples this will be introduced: <h3>Risk factors</h3> The case UK's National Institute for Health Care Excellence updated draft guidance diagnosis management hypertension in adults. evidence based increase However, do principles EBM any increased health risk become a disease as long it supported by positive...