A5080774964- Artificial Intelligence in Healthcare and Education
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare cost, quality, practices
- Ethics in Clinical Research
- Palliative Care and End-of-Life Issues
- Cancer-related gene regulation
- FOXO transcription factor regulation
- Pancreatic function and diabetes
- Ethics in medical practice
- Neuroendocrine Tumor Research Advances
- Health Systems, Economic Evaluations, Quality of Life
- Medical Malpractice and Liability Issues
- Neuroethics, Human Enhancement, Biomedical Innovations
- Explainable Artificial Intelligence (XAI)
- Cancer Genomics and Diagnostics
- Ethics and Social Impacts of AI
- TGF-β signaling in diseases
- Bacillus and Francisella bacterial research
- Torture, Ethics, and Law
- Radiology practices and education
- Neurological disorders and treatments
- Kruppel-like factors research
- Economic and Financial Impacts of Cancer
- Biliary and Gastrointestinal Fistulas
Hackensack Meridian Health
2021-2025
Santa Clara University
2020-2024
University Medical Center
2023
Hastings Center
2022
Kaiser Permanente Hayward Medical Center
2007
University of Michigan–Ann Arbor
2002-2004
Ann Arbor VA Medical Center
2004
Michigan Medicine
2002
Transforming growth factor β (TGFβ) interacts with cell surface receptors to initiate a signaling cascade critical in regulating growth, differentiation, and development of many types. TGFβ involves activation Smad proteins which directly regulate target gene expression. Here we show that also expression by using previously unrecognized pathway involving direct interaction protein kinase A (PKA). PKA has numerous effects on apoptosis, is generally initiated increased cellular cyclic AMP...
Objectives: Tissue desmoplasia occurs in a number of disease states, but its molecular basis is poorly understood. To determine which genes are overexpressed cells contained within the desmoplastic stroma pancreatic adenocarcinoma and chronic pancreatitis, we undertook genetic profiling microdissected tissue samples adenocarcinoma, normal pancreas, cancer cell lines. We observed that both pancreatitis showed elevated expression many shared compared with pancreas. hypothesized these common...
This article's main contributions are twofold: 1) to demonstrate how apply the general European Union's High-Level Expert Group's (EU HLEG) guidelines for trustworthy AI in practice domain of healthcare and 2) investigate research question what does "trustworthy AI" mean at time COVID-19 pandemic. To this end, we present results a post-hoc self-assessment evaluate trustworthiness an system predicting multiregional score conveying degree lung compromise patients, developed verified by...
Qualitative evidence on the relationship between quality of life and disabilities suggests that subjective judgments regarding other people's QoL are wrong more often than not.
Many regard iatrogenic injuries as consequences of diagnosis or intervention actions. But inaction-not offering indicated major surgery-can also result in injury. This article explores some surgeons' overestimations operative risk based on patients' race and socioeconomic status unduly influential their decisions about whether to perform cancer cardiac surgery patients with appropriate clinical indications. considers artificial intelligence machine learning-based decision support systems...
Medicine is at its core a moral pursuit driven largely by the duty to do good and avoid harm. This promise contained in Hippocratic Oath, which every physician some form professes. For surgeons, this has motivated research into how provide patients with highest-quality surgical care so as assure best outcomes (do good), reduce deaths complications (avoid harm). Multiple studies have demonstrated that hospital surgeon volumes are positively correlated operative outcome. Patients who undergo...
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Implantable brain-computer interface (BCI) and other devices with potential for both therapeutic purposes human enhancement are being rapidly developed. The distinction between uses of these is not well defined. While the US Food Drug Administration (FDA) rightly determines what safe effective, this article argues that FDA should make subjective, value-laden assessments about risks benefits when it comes to approval BCIs therapy enhancement. This also determining BCIs' society requires...