A5069308295- Analog and Mixed-Signal Circuit Design
- Low-power high-performance VLSI design
- Advancements in Semiconductor Devices and Circuit Design
- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Sensor Technology and Measurement Systems
- Coronary Interventions and Diagnostics
- Angiogenesis and VEGF in Cancer
- VLSI and FPGA Design Techniques
- Electromagnetic Compatibility and Noise Suppression
- Advancements in PLL and VCO Technologies
- Structural Engineering and Materials Analysis
- Waste Management and Environmental Impact
- Cardiac and Coronary Surgery Techniques
- Congenital heart defects research
- Innovative Energy Harvesting Technologies
- Embedded Systems Design Techniques
- Electrostatic Discharge in Electronics
- Advanced MEMS and NEMS Technologies
- Glycogen Storage Diseases and Myoclonus
- Radio Frequency Integrated Circuit Design
- Silicon Carbide Semiconductor Technologies
- Semiconductor Lasers and Optical Devices
- Parallel Computing and Optimization Techniques
- RNA Interference and Gene Delivery
Łukasiewicz Research Network - Institute of Welding
2012-2023
University of Computer Sciences and Economics in Olsztyn
2023
AGH University of Krakow
2006-2015
Silesian University of Technology
2014
Institute of Engineering
2014
Silesian Center for Heart Disease
2006-2012
Adult Congenital Heart Association
2010
Poznań University of Technology
2007
Ludwig-Maximilians-Universität München
2002-2004
University of Münster
2002-2003
This article's main contributions are twofold: 1) to demonstrate how apply the general European Union's High-Level Expert Group's (EU HLEG) guidelines for trustworthy AI in practice domain of healthcare and 2) investigate research question what does "trustworthy AI" mean at time COVID-19 pandemic. To this end, we present results a post-hoc self-assessment evaluate trustworthiness an system predicting multiregional score conveying degree lung compromise patients, developed verified by...
The abnormal accumulation of lipid-rich adipose tissue within the interatrial septum (IAS) is hallmark lipomatous hypertrophy (LHIS), a relatively rare medical condition. To accurately distinguish LHIS, it essential to recognize characteristic "dumbbell" shape IAS. Here, we present case 59-year-old woman who was suspected having cardiac myxoma and subsequently admitted our hospital. Transthoracic echocardiography patient showed that IAS had lack thickening in region foramen ovale...
The aim of this study was to determine the prevalence rates mucopolysaccharidoses in Poland and compare them with other European countries. A retrospective epidemiological survey covering period between 1970 2010 implemented. Multiple ascertainment sources were used identify affected patients. overall Polish population 1.81 per 100,000. Five different diagnosed a total 392 individuals. MPS III most frequent mucopolysaccharidosis, birth 0.86 100,000 live births. approximately 0.22 cases...
<i>Aim:</i> This study evaluated the impact of hyperuricemia (HUR) on outcome in patients with different types impaired renal function (IRF) and acute myocardial infarction (AMI) treated invasively. <i>Methods:</i> Out 3,593 consecutive AMI invasively, 1,015 IRF were selected. The group consisted baseline kidney dysfunction (BKD group) and/or contrast-induced nephropathy (CIN group). HUR was defined as a serum uric acid concentration (SUAC) >420 µmol/l (>7...
The aim of this study was to describe the natural clinical course, incidence and prevalence mucopolysaccharidosis type VI (MPS VI) in Russia, Kazakhstan, Central Eastern Europe.Patients (n = 49) were identified by retrieving data from eight international centers for MPS VI.A large number patients presented with an attenuated phenotype (33%). Height genotype related severity disease, while no clear trend observed between height urinary glycosaminoglycan level. A high p.R152W mutation both...
Abstract Mucopolysaccharidosis type VI (MPS VI) is a rare lysosomal, autosomal recessive storage disorder caused by deficient activity of N ‐acetylgalactosamine‐4‐sulfatase (ARSB). Approximately, 140 ARSB gene mutations have been identified; however, most are private making genotype–phenotype correlation for MPS patients difficult. The aim this study was to describe the natural clinical course in homozygous p.R152W mutation from eight unrelated families. From our database 70 with VI, we...
In the research, a numerical Computational Fluid Dynamics (CFD) model of pulsatile blood flow was created and analysed. A real geometry aorta its thoracic branches an 8-year old patient diagnosed with congenital heart defect – coarctation used. The inlet boundary condition implemented as User Define Function according to measured values volumetric flow. treated multiphase using Euler-Euler approach. Plasma set primary dominant fluid phase, volume fraction 0.585. morphological elements (RBC...
ABSTRACT Clinical trials have demonstrated therapeutic benefit in inducing angiogenesis chronic occlusive arterial disease. The route of application mostly used was the intramuscular injection high dosages plasmid. Therefore, a local perivascular low amounts vascular endothelial growth factor (VEGF) plasmid an interventional occlusion model, and effect VEGF on coronary peripheral occlusions compared same animal model. Coronary arteries were chronically occluded Pietrain pigs using...
In the research a numerical Computational Fluid Dynamics (CFD) model of pulsatile blood flow was created and analyzed. A real geometry aorta its thoracic branches 8-year old patient diagnosed with congenital heart defect - coarctation used. The inlet boundary condition were implemented as User Define Function according to measured values volumetric flow. treated multiphase: plasma, set primary fluid phase, dominant volume fraction 0.585 morphological elements in Euler-Euler approach...
Abstract The paper analyzes the phenomenon of heat transfer and its inertia in solids. influence this effect on operation an integrated circuit is described. explained using thermal analogy implemented Spice environment by R-C model. Results from model are verified some measurements with a chip designed CMOS 0.7 μm (5 V) technology. microcontroller-based measurement system structure experiment results
The paper presents theoretical analyses, simulations and design of a PTAT (proportional to absolute temperature) temperature sensor that is based on the vertical PNP structure dedicated CMOS VLSI circuits. Performed considerations take into account specific properties materials forms electronic elements. electrothermal are performed in order verify unwanted self-heating effect
The potential of two small poly-<i>L</i>-lysines (sPLLs), low molecular weight sPLL (LMW-L) containing 7–30 lysine residues and L18 with 18 repeats, to enhance the efficiency liposome-mediated gene transfer (GT) cationic lipid DOCSPER [1,3-dioleoyloxy-2-(N<sup>5</sup>-carbamoyl-spermine)-propane] in vascular smooth muscle cells (SMCs) was investigated. Dynamic light scattering used for determination particle size. Confocal microscopy applied colocalization studies...
Purpose The purpose of this paper is the application computational fluid dynamics model simulating blood flow within aorta an eight-year-old patient with Coarctation Aorta. Design/methodology/approach numerical model, based on commercial code ANSYS Fluent, was built using multifluid Euler–Euler approach interaction between phases described by kinetic theory granular (KTGF). Findings A in arches main branches has been presented. KTGF. and pressure patterns, as well volumetric concentration...
Computer modeling combined with non-invasive measurement modalities may provide a means to advanced diagnosis and treatment of cardiovascular diseases; however, development validation novel methods is often impeded by the challenge gathering relevant clinical data. We present an experimental rig phantom model left common carotid artery developed generate data necessary for computational artery. The flow rates pressures at inlet outlet, deformation were measured simultaneously optical...
Angiogenesis and arteriogenesis play an important role in advanced vascular occlusive diseases. Whether angiogenesis or predominate depends on the preexisting collateral vessel network, type location of occlusion, different developmental origin arteries. were investigated following endothelial growth factor (VEGF) treatment arteries arterial diseases using a newly developed porcine occlusion model. Porcine coronary peripheral occluded interventionally blinded stent grafts. Gene transfer was...
PURPOSE To use local gene delivery to determine any district-specific influence of vascular endothelial growth factor (VEGF(165)) on angiogenesis and arteriogenesis in arteries distinct developmental origin. METHODS Coronary peripheral were chronically occluded 30 Pietrain pigs using a percutaneous approach blinded stent-graft. DNA was delivered the adventitia dosages corresponding 10% body weight-adapted amount used clinical trials. The coronary 12 animals treated or as controls (no...
Mucopolysaccharidosis type VI (MPS VI) is an autosomal recessive lysosomal disorder caused by a deficient activity of N-acetylgalactosamine-4-sulfatase (ARSB). Pulmonary hypertension (PH) occurs in MPS patients and marker bad prognosis. Malfunction endothelium, which regulates vascular tonus stimulates angiogenesis, can contribute to the occurrence PH VI.The aim study was establish human cellular model pulmonary artery endothelial cells (HPAECs) evaluate how it affects factors that may...
Both the energy consumption and propagation time delay are very critical parameters of contemporary integrated circuits. It is obvious that a circuit should consume as small possible ought to work with maximum speed efficiency. However, these dependent on temperature, which can change both external (e.g. high surrounding temperature) internal power dissipated in circuit) conditions. The article presents temperature influence CMOS ASIC circuits at example AMI Semiconductor 0.7 /spl mu/ C07MD...