A5063988060- Trace Elements in Health
- Mitochondrial Function and Pathology
- Nutrition and Health Studies
- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Light effects on plants
- Redox biology and oxidative stress
- Alzheimer's disease research and treatments
- Prion Diseases and Protein Misfolding
- Skin Protection and Aging
- Effects of Radiation Exposure
- ATP Synthase and ATPases Research
- Genetics, Aging, and Longevity in Model Organisms
- Diet and metabolism studies
- Nutritional Studies and Diet
- Cardiovascular Conditions and Treatments
- Radiation Dose and Imaging
- Protein Structure and Dynamics
- Cervical Cancer and HPV Research
- Peptidase Inhibition and Analysis
- Mast cells and histamine
- Wireless Power Transfer Systems
The Maria Sklodowska-Curie National Research Institute of Oncology
2014-2023
Silesian University of Technology
2014-2019
Nofer Institute of Occupational Medicine
2018-2019
Wroclaw University of Economics and Business
2017
Warsaw University of Life Sciences
2014-2016
Interuniversity Consortium for Magnetic Resonance
2012-2015
University of Florence
2012-2015
University of Siena
2009
Significance Cellular respiration in humans depends on the correct assembly of a copper site (Cu A ) cytochrome oxidases. Because is toxic at high levels, cells require specific mechanisms to regulate transport and delivery. Two proteins from Sco family are involved this mechanism human mitochondria, mutations any these jeopardize Cu site, leading lethal pathologies newborns. We show that Sco1 protein responsible for delivering ions oxidase, with degree selectivity. Sco2, instead, provides...
The interaction of Mia40 with Erv1/ALR is central to the oxidative protein folding in intermembrane space mitochondria (IMS) as oxidizes reduced restore its functional state. Here we address role import and maturation Erv1/ALR. C-terminal FAD-binding domain has an essential process by creating a transient intermolecular disulfide bond Mia40. action selective for formation both intra intersubunit structural bonds Erv1/ALR, but complete requires additional binding FAD. Both these events must...
According to literature data, self-renewing, multipotent, and clonogenic cardiac c-Kit(+) progenitor cells occur within human myocardium. The aim of this study was isolate characterize from explanted hearts. Experimental material obtained 19 adult 7 pediatric patients. Successful isolation culture achieved for 95 samples (84.1%) derived five different regions the heart: right left ventricles, atrium, intraventricular septum, apex. average percentage cells, as assessed by FACS, ranged between...
Ultraviolet A (UVA) radiation is harmful for living organisms but in low doses may stimulate cell proliferation. Our aim was to examine the relationships between exposure different UVA doses, cellular proliferation, and changes reactive oxygen species levels. In human colon cancer (HCT116) melanoma (Me45) cells exposed comparable environmental, highest (30–50 kJ/m2) reduced clonogenic potential some lower (1 10 induced This effect type dose specific. both lines levels of nitric oxide...
Active demethylation of 5-methylcytosine moiety in DNA occurs by its sequential oxidation to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, catalysed enzymes the Ten-Eleven Translocation family proteins (TETs 1, 2 3). Here we analyzed for first time all intermediate products pathway form deoxynucleosides (5-methyl-2′-deoxycytidine, 5-(hydroxymethyl)-2′-deoxycytidine, 5-formyl-2′-deoxycytidine 5-carboxy-2′-deoxycytidine as well 5-(hydroxymethyl)-2′-deoxyuridine) using...
Combined potentiometric, calorimetric and spectroscopic methods were used to investigate the Cu2+ binding ability coordination behaviour of some peptide fragments related neurotoxic region chicken Prion Protein. The systems studied following protein fragments: chPrP106–114, chPrP119–126, chPrP108–127, chPrP105–127 chPrP105–133.
Mucopolysaccharidosis type VI (MPS VI) is an autosomal recessive lysosomal disorder caused by a deficient activity of N-acetylgalactosamine-4-sulfatase (ARSB). Pulmonary hypertension (PH) occurs in MPS patients and marker bad prognosis. Malfunction endothelium, which regulates vascular tonus stimulates angiogenesis, can contribute to the occurrence PH VI.The aim study was establish human cellular model pulmonary artery endothelial cells (HPAECs) evaluate how it affects factors that may...
Abstract Circulating tumor HPV DNA (ctHPV16) assessed in liquid biopsy may be used as a marker of cancer patients with HPV-associated oropharyngeal (HPV + OPC). Factors influencing the initial ctHPV16 quantity are not well recognized. In this study we aimed to establish what factors related level at time diagnosis. 51 (37 men and 14 women, median age 57 years old) OPC prior definitive treatment were included. was measured by qPCR. Tumor nodal staging according AJCC8. Blood derived included...
Adenoid cystic carcinoma (ACC) should be treated with a surgical procedure. Unfortunately, in some cases, such procedures are impossible to perform. In that event, radiotherapy can used as form of radical treatment, although ACC is established radio- and chemoresistant tumour. Therefore, unconventional fractionated needs considered.Here, we present case study patient an unresectable tumour the choanae nasopharynx stereotactic boost combination conventional radiotherapy. We achieved complete...
Abstract Ultraviolet A (UVA) radiation is harmful for living organisms but in low doses may stimulate cell proliferation. Our aim was to examine the relationships between exposure different UVA doses, cellular proliferation, and changes reactive oxygen species levels. In human colon cancer (HCT116) melanoma (Me45) cells exposed comparable environmental, highest (30-50 kJ/m 2 ) reduced clonogenic potential some lower (1 10 induced This effect type dose specific. both lines levels of nitric...
Burkitt-like lymphoma with 11q aberration (BLL-11q) is a rare entity affected mainly young people and generally manifested nodal involvements. The lack of MYC translocation the hallmark BLL-11q while morphological features resemble those classical Burkitt (BL). Therefore, usually treated according to recommendations for BL. However, there no standard care in patients BLL 11q. We present 19-year-old man initial diagnosis appendicitis. Microscopic examination resected tissue, supported by...
Większość żywych organizmów jest narażona na działanie promieniowania UV, czynnik toksyczny i genotoksyczny powodujący śmierć komórki zahamowanie proliferacji. Celem pracy było sprawdzenie odpowiedzi komórkowej promieniowanie UV w trzech liniach komórkowych Me45, NHDF oraz HCT116, z których dwie są wyprowadzone komórek występujących skórze, takich, które mogą być bezpośrednio narażone to promieniowanie. Badano podziały komórkowe oceniano stopień indukcji apoptozy użyciem zmodyfikowanego...