A5049923289- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Effects of Radiation Exposure
- Oral health in cancer treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
The Maria Sklodowska-Curie National Research Institute of Oncology
2016-2025
Institut Curie
2003-2019
Centrum Onkologii
1998-2017
HealthPartners
2014
Taichung Veterans General Hospital
2013
Gdańsk Medical University
2012
Medical University of Lodz
2012
Warsaw University of Technology
2010
Institute of Computer Science
2010
Medical University of Silesia
2006
Abstract Background Early detection of treatment failure may improve clinical outcome and overall survival in patients with head neck cancer after first-line treatment. Circulating cell-free HPV16 DNA (cfHPV16 DNA) was evaluated as a possible complementary marker to radiological assessment early response HPV-related oropharyngeal (OPC) radiotherapy alone or combined chemotherapy. Methods The study included 66 OPC receiving radical combination cfHPV16 assessed the blood all before using...
The aim of this analysis was to evaluate the platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte (NLR), platelets (PLT), and neutrophil level for their prognostic value in patients with metastatic renal cell carcinoma (mRCC).We retrospectively reviewed medical records 141 mRCC (2006-2016). Univariate multivariate analyses were performed Cox proportional hazards regression model. cutoff NLR "elevated" as >3.68 PLR >144.4.The median PFS OS shorter elevated PLR. A higher PLT associated worse...
The oral cancer treatment of choice is surgical excision with an organ preservation, if it possible. Radiation therapy commonly used as a postoperative treatment. Delivering radiation dose during surgery, defined intraoperative radiotherapy (IORT), can be very useful especially in case high risk recurrence or where gross macroscopic residual disease are present. aim this retrospective study to evaluate the effectiveness IORT combined fractionated irradiation (EBRT) patients squamous cell...
Background: In general, the serum metabolome reflects patient’s body response to both disease state and implemented treatment. Though serum-derived exosomes are an emerging type of liquid biopsy, metabolite content these vesicles remains under researched. The aim this pilot study was compare profiles whole in context differences between cancer patients healthy controls as well patients’ radiotherapy (RT). Methods: Serum samples were collected from 10 volunteers with head neck before after...
The addition of CDK4/6 inhibitors to endocrine therapy in advanced hormone receptor-positive HER2-negative breast cancer has led practice-changing improvements overall survival. However, data concerning the safety CDK4/6i combination with radiotherapy (RT) are conflicting. A retrospective evaluation 288 patients (pts) treated was performed, and 100 pts also received RT. Forty-six 63 RT courses concurrently fifty-four sequentially before initiation (76 courses). Neutropenia common (79%) more...
Cancer radiotherapy (RT) induces response of the whole patient’s body that could be detected at blood level. We aimed to identify changes induced in serum lipidome during RT and characterize their association with doses volumes irradiated tissue. Sixty-six patients treated conformal because head neck cancer were enrolled study. Blood samples collected before, about one month after end RT. Lipid extracts analyzed using MALDI-oa-ToF mass spectrometry positive ionization mode. The major...
Background: There are definite reasons to implement molecular diagnostics based on the measurement of human papillomavirus (HPV) DNA in liquid biopsy into clinical practice. It is a quick, repeatable, and health-safe test for cancer biomarkers blood. In this study, we investigated whether circulating tumor-related HPV16 (ctHPV16) viral load (VL) patients with oropharyngeal squamous cell carcinoma (OPSCC) was important determining risk locoregional recurrence-free survival (LRFS),...
Angiogenesis is essential for growth, progression, and metastasis of solid tumors. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) angiopoietin (ANGPT)/ tyrosine kinase (TEK) signaling plays an important role in regulating angiogenesis. Very little known about the effects single-nucleotide polymorphisms (SNPs) angiogenesis-related genes on treatment outcome head neck squamous cell carcinoma (HNSCC). Therefore, we evaluated association between SNPs ANGPT1, ANGPT2, TEK, VEGF,...
Anticancer treatment induces systemic molecular changes that could be detected at the level of biofluids. Understanding how human metabolism is influenced by these treatments crucial to predict individual response and adjust personalized therapies. Here, we aimed compare profiles metabolites in serum head neck cancer patients treated with concurrent chemo-radiotherapy, radiotherapy alone, or induction chemotherapy. Serum samples were analyzed a targeted quantitative approach using combined...
Several immune and hematological parameters are associated with survival in patients oropharyngeal cancer (OPC). The aim of the study was to analyze selected HPV-related (HPV+) HPV-unrelated (HPV−) OPC, before after radiotherapy/chemoradiotherapy (RT/CRT) assess impact these on survival. One hundred twenty seven HPV+ HPV− treated RT alone or concurrent chemoradiotherapy (CRT), were included. Patients divided according HPV status. Confirmation etiology obtained from FFPE (Formalin-Fixed,...
The precise analysis of tumour markers in blood such as circulating cell-free DNA (cfDNA) could have a significant impact facilitating monitoring patients after initial therapy. Although high levels total cfDNA plasma cancer are consistently demonstrated, low sensitivity alterations is reported.The major question regards the recovery tumour-specific KRAS mutated and cancer-associated type 16 human papillomavirus (HPV16).TaqMan technology was used for detection mutation, HPV16 to quantify...
Mass spectrometry-based analyses of the low-molecular-weight fraction serum proteome allow identifying profiles (signatures) that are potentially useful in detection and diagnostics cancer. Here we compared healthy donors patients with three different types cancer aiming to identify peptide signatures were either common for all samples or specific type. Blood collected before start therapy from head neck squamous cell cancer, colorectal adenocarcinoma non-small lung a corresponding group...
Abstract Background Development of biomarker analysis using the circulating cell‐free DNA (cfDNA) methodology is a challenge for noninvasive cancer diagnosis. In this study, comparison between plasma and tumor tissue HPV16 viral loads (VLs) has been presented. Methods Real‐time polymerase chain reaction was performed quantitating in samples patients with oropharyngeal cancer. Results Among tissues, HPV16‐positive squamous cell carcinoma, nonsmoking patients, displayed significantly higher...