A5083233367- Immune cells in cancer
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
- interferon and immune responses
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- Diabetic Foot Ulcer Assessment and Management
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Periodontal Regeneration and Treatments
- Neuroscience and Neural Engineering
- NF-κB Signaling Pathways
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Inflammatory mediators and NSAID effects
- Nitric Oxide and Endothelin Effects
- Congenital heart defects research
- Chemokine receptors and signaling
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Cardiovascular Conditions and Treatments
- Cardiovascular Disease and Adiposity
The Maria Sklodowska-Curie National Research Institute of Oncology
2015-2025
Centrum Onkologii
2014
Tumor-associated macrophages (TAMs) play a significant role in at least two key processes underlying neoplastic progression: angiogenesis and immune surveillance. TAMs phenotypic changes important tumor vessel abnormalization/ normalization. M2-like stimulate immunosuppression formation of defective blood vessels leading to progression. In contrast M1-like trigger response normalize irregular vascular network which should sensitize cancer cells chemo- radiotherapy lead growth regression....
Adipose tissue-derived mesenchymal stromal cells (ASCs) have been shown to exhibit some promising properties of their use in regenerative medicine as advanced therapy medicinal products (ATMP). However, different sources origin, methods isolation, and expansion procedures cause the laboratory clinical results difficult compare. ASCs were isolated from lipoaspirates cultured three medium formulations: αMEM DMEM a basal supplemented with 10% human platelet lysate (hPL) 20% fetal bovine serum...
Abstract Immunotherapy is one of the most promising anti-cancer treatment. It involves activating host's own immune system to eliminate cancer cells. Activation cGAS-STING pathway therapeutic approach for immunotherapy. However, in human clinical trials, targeting results insufficient or unsustainable anti-tumor response. To enhance its effectiveness, combination with other therapies seems essential achieve synergistic systemic The aim this study was evaluate whether STING agonist-cGAMP...
Background/Objectives: The stimulator of interferon genes (STING) is currently accepted as a relevant target for anti-cancer therapies. Besides encouraging results showing STING agonist-induced tumor growth inhibition, in some types tumors the effect less prominent. We hypothesized that higher levels cancer cells and possibility its activation determine greater response. As local administration agonists induces systemic reaction, we emphasized importance host tumor-induced hematological...
Aims The aim of the present study was to isolate mesenchymal stromal cells (MSC) with CD105+CD34- phenotype from human hearts, and investigate their therapeutic potential in a mouse model hindlimb ischemia myocardial infarction (MI). aimed also feasibility xenogeneic MSCs implantation. Methods Results MSC isolated hearts were multipotent cells. Separation limited heterogeneity originally cell population. secreted number anti-inflammatory proangiogenic cytokines (mainly IL-6, IL-8, GRO)....
Abstract Due to immunosuppressive properties and confirmed tropism towards cancer cells mesenchymal stromal (MSC) have been used in many trials. In our study we these as carriers of IL-12 the treatment mice with primary metastatic B16-F10 melanomas. has anti-cancer activity, induces a strong immune response against acts an anti-angiogenic agent. A major limitation use therapy is its systemic toxicity. The aim work was develop system which cytokine may be administered intravenously without...
Introduction Targeting tumor vasculature is an efficient weapon to fight against cancer; however, activation of alternative pathways rebuild the disrupted leads rapid regrowth. Immunotherapy that exploits host immune cells elicit and sustain potent antitumor response has emerged as one most promising tools for cancer treatment, yet many treatments fail due developed resistance mechanisms. Therefore, our aim was examine whether combination immunotherapy anti-vascular treatment will succeed in...
D-K6L9 peptide is bound by phosphatidylserine and induces necrosis in cancer cells. In our therapeutic experience, this peptide, when administered directly into B16-F10 murine melanoma tumors, inhibited their growth. Cessation of therapy results, however, tumor relapse. We aimed at developing a combined involving additional factors that would yield complete elimination cells experimental animals. To purpose, we employed glycyrrhizin, an inhibitor HMGB1 protein, BP1 interleukin (IL)-12....
According to literature data, self-renewing, multipotent, and clonogenic cardiac c-Kit(+) progenitor cells occur within human myocardium. The aim of this study was isolate characterize from explanted hearts. Experimental material obtained 19 adult 7 pediatric patients. Successful isolation culture achieved for 95 samples (84.1%) derived five different regions the heart: right left ventricles, atrium, intraventricular septum, apex. average percentage cells, as assessed by FACS, ranged between...
Vascular disrupting agents (VDAs), such as DMXAA, effectively destroy tumor blood vessels and cause the formation of large areas necrosis in central parts tumors. However, use VDAs is associated with hypoxia activation residues rim cells on edge that are responsible for regrowth. The aim study was to combine DMXAA radiotherapy (brachytherapy) find appropriate administration sequence obtain maximum synergistic therapeutic effect. We show combination which tumors were irradiated prior more...
Abstract Background Adipose-derived stromal cells (ADSCs) demonstrate ability to promote tissue healing and down-regulate excessive inflammation. ADSCs have been used treat critical limb ischemia in preclinical clinical trials, but still, there is little known about their optimal delivery strategy. To date, no direct analysis of different methods has performed the hindlimb model. Therefore, this study we focused on therapeutic efficacy a murine model ischemia. Methods For hADSCs isolation,...
Radiotherapy (RT) is one of the major methods cancer treatment. RT destroys cells, but also affects tumor microenvironment (TME). The delicate balance between immunomodulation processes in TME dependent, among other things, on a specific radiation dose. Despite many studies, optimal dose has not been clearly determined. Here, we demonstrate that brachytherapy (contact radiotherapy) inhibits melanoma growth dose-dependent manner. Doses 10Gy and 15Gy cause most effective inhibition compared to...
Neovascularization, the process of new blood vessels formation in response to hypoxia induced signals, is an essential step during wound healing or ischemia repair. It follows as a cascade consecutive events leading and their subsequent remodeling mature functional state, enabling tissue regeneration. Any disruption stages neovascularization can lead chronic wounds impairment In study we try explain biological basis accelerated ischemic after adipose tissue-derived stromal cells (ADSCs)...
<h3>Abstract</h3> Background/Aim: Numerous studies have demonstrated an anti-cancer action of plant-derived polyphenols. Their is mainly related to antioxidant, anti-inflammatory, immunomodulatory and inhibitory properties. It expected that proper composition nutrition factors with activity may prevent from cancer incidence or inhibit progression. The aim the study was investigate properties a standardized compounds: trans-resveratrol, quercetin, vitamin E selenium (Neoplasmoxan, Vebiot) in...
One of the preconditions effective anticancer therapy is efficient transfer therapeutic agent (chemotherapeutic) to tumor cells. Fundamental barriers making drug delivery and action difficult include underoxygenation, elevated interstitial pressure, poor abnormal blood vascular network acidic milieu. In this study we aimed at developing an optimized scheme administering a combination angiogenesis-inhibiting (vasostatin) chemotherapeutic (cyclophosphamide) in treatment mice bearing...
Mesenchymal stromal cells isolated from different tissues are claimed to demonstrate similar therapeutic potential and often incorrectly named mesenchymal stem cells. However, through comparison of such is lacking. This study aimed compare the transcriptome same phenotype heart muscle epicardial fat patient, before after culture.Cells were biopsies right ventricle collected five patients (three men two women, mean age 59.4 ± 2.6) who underwent transplantation due ischaemic cardiomyopathy. In...
Radiotherapy (RT) is one of the main treatments for head and neck squamous cell carcinomas (HNSCCs). Unfortunately, radioresistance observed in many cases HNSCCs. The effectiveness RT depends on both direct effect inducing death indirect changing tumor microenvironment (TME). Knowledge interactions between TME components after may help to design a new combined treatment with RT. In study, we investigated survival secretion co-culture model HNSCCs vitro. We examined changes proliferation,...