A5057413181- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Trypanosoma species research and implications
- Calcium signaling and nucleotide metabolism
- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Neural dynamics and brain function
- Neonatal Respiratory Health Research
- Neurogenesis and neuroplasticity mechanisms
- Cellular transport and secretion
- Congenital heart defects research
- Cancer Immunotherapy and Biomarkers
- Neuroscience and Neural Engineering
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Photoreceptor and optogenetics research
- Nicotinic Acetylcholine Receptors Study
- Biochemical and Molecular Research
- Memory and Neural Mechanisms
- Diet and metabolism studies
- Research on Leishmaniasis Studies
- Proteoglycans and glycosaminoglycans research
- Neuroscience of respiration and sleep
- Lysosomal Storage Disorders Research
University of Virginia
2019-2023
Max Perutz Labs
2020-2021
Medical University of Vienna
2020-2021
Vienna Biocenter
2021
Silesian University of Technology
2021
The Maria Sklodowska-Curie National Research Institute of Oncology
2018
Tumor-associated macrophages (TAMs) play a significant role in at least two key processes underlying neoplastic progression: angiogenesis and immune surveillance. TAMs phenotypic changes important tumor vessel abnormalization/ normalization. M2-like stimulate immunosuppression formation of defective blood vessels leading to progression. In contrast M1-like trigger response normalize irregular vascular network which should sensitize cancer cells chemo- radiotherapy lead growth regression....
Abstract Repetitively firing neurons during seizures accelerate glycolysis to meet energy demand, which leads the accumulation of extracellular glycolytic by-product lactate. Here, we demonstrate that lactate rapidly modulates neuronal excitability in times metabolic stress via hydroxycarboxylic acid receptor type 1 (HCA1R) modify seizure activity. The concentration, measured by a biosensor, rose quickly brief and prolonged seizures. In two epilepsy models, mice lacking HCA1R (lactate...
Objective To identify circuits active during neonatal hypoxic–ischemic (HI) seizures and seizure propagation using electroencephalography (EEG), behavior, whole‐brain neuronal activity mapping. Methods Mice were exposed to HI on postnatal day 10 unilateral carotid ligation global hypoxia. EEG video recorded for the duration of experiment. Using immediate early gene reporter mice, cells expressing cfos permanently tagged with protein tdTomato a 90‐minute window. After 1 week, allowing maximal...
Abstract Objective Status epilepticus (SE) requires rapid intervention to prevent cerebral injury and mortality. The ketogenic diet, which bypasses glycolysis, is a promising remedy for patients with refractory SE. We tested the role of glycolytic lactate production in sustaining Methods Extracellular glucose concentration during seizure SE vivo was measured using biosensors. A dehydrogenase inhibitor, oxamate, blocked pyruvate conversion Video‐EEG recordings evaluated duration, severity,...
Hypoxia ischemia is the most common cause of neonatal seizures. Animal models are crucial for understanding mechanisms and physiology underlying seizures hypoxia ischemia. This manuscript describes a method continuous video electroencephalogram (EEG) monitoring in mice to detect analyze EEG background during Use conjunction allows description seizure semiology confirmation also analysis power spectrograms pattern trends over experimental time period. In this model, recording prior injury...
Hypoxia ischemia is the most common cause of neonatal seizures. Animal models are crucial for understanding mechanisms and physiology underlying seizures hypoxia ischemia. This manuscript describes a method continuous video electroencephalogram (EEG) monitoring in mice to detect analyze EEG background during Use conjunction allows description seizure semiology confirmation also analysis power spectrograms pattern trends over experimental time period. In this model, recording prior injury...
Extended synaptotagmins (E-Syts) localize at membrane contact sites between the endoplasmic reticulum (ER) and plasma to mediate inter-membrane lipid transfer control homeostasis. All known E-Syts contain an N-terminal transmembrane (TM) hairpin, a central synaptotagmin-like mitochondrial lipid-binding protein (SMP) domain, three or five C2 domains their C termini. Here we report uncharacterized E-Syt from protist parasite
Extended synaptotagmins (E-Syts) are a group of evolutionarily conserved proteins localizing at membrane contact sites between the endoplasmic reticulum (ER) and plasma membrane, where they mediate inter-membrane lipid transfer control homeostasis. There three E-Syts in mammals, which all contain an N-terminal transmembrane (TM) hairpin for association with ER central synaptotagmin-like mitochondrial-lipid binding protein (SMP) domain as carrier phospholipids. Additionally, mammalian E-Syt1...
Extended synaptotagmins (E-Syts) are a group of evolutionarily conserved proteins localizing at membrane contact sites between the endoplasmic reticulum (ER) and plasma membrane, where they mediate inter-membrane lipid transfer control homeostasis. There three E-Syts in mammals, which all contain an N-terminal transmembrane (TM) hairpin for association with ER central synaptotagmin-like mitochondrial-lipid binding protein (SMP) domain as carrier phospholipids. Additionally, mammalian E-Syt1...