A5075697375- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Circular RNAs in diseases
- Neuroendocrine Tumor Research Advances
- Vitamin D Research Studies
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Nutritional Studies and Diet
- Regulation of Appetite and Obesity
- Effects of Radiation Exposure
- Glycosylation and Glycoproteins Research
- Glutathione Transferases and Polymorphisms
- Viral-associated cancers and disorders
- Vitamin C and Antioxidants Research
- Electrolyte and hormonal disorders
- Cancer-related gene regulation
- Brain Metastases and Treatment
- Diet, Metabolism, and Disease
- Digestive system and related health
- Neuroblastoma Research and Treatments
Medical University of Silesia
2017-2024
Oxidative stress may play an important role in colorectal cancer (CRC). The present study included 94 adult patients with CRC (52 men and 42 women) 26 hospitalized (12 14 whom was excluded (control group). During hospitalization, blood serum samples were collected from both groups. Apart that, anthropometric measurements taken other clinical data analyzed. Serum malondialdehyde (MDA) level, total oxidant status (TOS), antioxidant (TAS) oxidative index (OSI) assayed. Subsequently, the...
Colorectal cancer is one of the most common cancers in world. Due to its still undetermined pathogenesis, we are searching for signaling pathways that important development colorectal cancer. In this article, present results study on role ADAM proteins The included 85 adult patients (48 men, 37 women) and 25 control group (after diagnostic colonoscopy-without cancer). During hospitalization, a serum sample (3 cm3) was collected from group, anthropometric measurements were conducted others...
Vitamin D is a fat-soluble cholesterol derivative found in two forms, vitamin D2, and D3. Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene major hydroxylase that activates catalyzing formation of 25-hydroxyvitamin (25(OH)D). We collected 89 (100%) subjects, 46 which (51.69%) had documented severe deficiency 25(OH)D (<10 ng/mL) 43 (48.31%) control group with optimum levels (>30 ng/mL). performed Sanger sequencing three selected fragments (Ch11: 14878000-14878499; Ch11:...
Background: Aberrant DNA methylation is a common epigenetic modification in cancers, including oropharyngeal squamous cell carcinoma (OPSCC) and oral (OSCC). Therefore, the analysis of levels appears necessary to improve cancer therapy prognosis. Methods: The enzyme-linked immunosorbent assay (ELISA) was used analyse global OPSCC OSCC tumours margin samples after isolation. HPV detection conducted by hybridisation using GenoFlow Array Test Kits (DiagCor Bioscience Inc., Hong Kong, China)....
Neuroendocrine tumors (NETs) are a heterogeneous group of that characteristically different from other malignancies. The difference is not only in the prognosis, which usually more favorable such patients, but also high clinical progression disease, where NET patients do experience cachexia typical purposes this study were to evaluate ghrelin and leptin levels diagnosed with gastroenteropancreatic neuroendocrine (GEP-NETs) bronchopulmonary (BP-NETs) analyze relationship between body mass...
Aim. The gene encoding the vitamin D receptor (VDR) is considered in many studies to be a good candidate responsible for susceptibility several diseases such as coronary artery disease (CAD). Epidemiological data show that cardiovascular one of major health problems Polish society. Basic genetic factors play significant role pathogenesis CAD. We conducted this clinical study determine if VDR polymorphisms TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) could predispose healthy...
Telomerase, undetectable in normal somatic cells, plays a critical role carcinogenesis of the majority human tumors including lung carcinoma. The aim our study was to determine telomerase reverse transcriptase (hTERT) mRNA expression patients with non-small cell cancer (NSCLC) order estimate its usefulness as diagnostic and/or prognostic factor. hTERT analyzed group 12 females and 28 males NSCLC using Quantitative Real-Time Polymerase Chain Reaction (QRT-PCR method) cancerous non-cancerous...
Epstein-Barr virus (EBV) is a common worldwide that an etiologic agent in the development of many diseases, including cancer. Recent reports have shown association EBV with tumorigenesis head and neck squamous cell carcinoma (HNSCC). Moreover, has been reported to be present tonsillar tissues, which suggests close relationship between viral infections chronic tonsillitis. The aim study was analyze prevalence DNA 86 patients HNSCC, 70 tonsillitis, 144 healthy individuals (control group)...
Head and neck squamous cell carcinoma (HNSCC) is one of the leading cancers by incidence worldwide. The risk these strictly associated with alkylation factors present in tobacco smoke. crucial role preventing DNA played O6-methylguanine-DNA methyltransferase (MGMT). Dysfunction or lack MGMT an increased cancer. aim study was to assess influence polymorphisms: Rs12917 Rs11016879 on HNSCC course. consisted 42 patients 58 healthy individuals. Case samples were taken from resected tumour tissue....
Human papillomavirus (HPV) is a virus with the potential to infect human epithelial cells and an etiological agent of many types cancer, including head neck cancer. The aim study was determine prevalence HPV infection in patients squamous cell carcinoma (HNSCC), chronic tonsillitis, healthy individuals, establish high- low-risk genotypes these groups. objectives also comprised delineation relationship between or subtypes clinicopathological demographic characteristics This composed 76...
Interconnections between hypothyroidism and metabolic disturbances manifesting in the liver body composition have not yet been comprehensively analyzed context of lifestyle. This study aimed to assess selected lifestyle factors quality life development NAFL (non-alcoholic fatty liver) women diagnosed with hypothyroidism. included 134 categorized into three groups: NAFL, only hypothyroidism, NAFL. We compared groups concerning KomPAN WHOQOL-BREF questionnaires, anthropometric measurements,...
Exposure of living cells to ionizing radiation has different consequences, depending on the dose and cell type. Changes in gene expression at level transcription translation, including those regulated by microRNAs (miRNAs), play a role intrinsic radiosensitivity define their fate, survival or death. The aim our work was examine how may influence genes miRNAs miRNA biogenesis.The performed cultured human melanoma Me45 cells, transiently transfected with plasmids containing Renilla luciferase...
Rapid changes in the expression of many messenger RNA (mRNA) species follow exposure cells to ionizing radiation. One hypothetical mechanisms this response may include microRNA (miRNA) regulation, since amounts miRNAs also vary upon irradiation. To address possibility, we designed experiments using cancer-derived cell lines transfected with luciferase reporter gene containing sequences targeted by different miRNA its 3′- untranslated region. We focus on early time-course (1 h past...
Currently, there are no effective markers to diagnose and monitor patients with neuroendocrine tumors (NETs). The aim of this study was assess bone metabolism based on selected turnover: OST, OPG, IGFBP-3, in both the group NETs control group. Associations sociodemographic, biochemical, clinicopathological characteristics were examined. We also evaluated any potential associations between these biochemical commonly used clinical practice. included 60 GEP-NETs BP-NETs, while comprised 62...
Oral squamous cell carcinoma (OSCC) and oropharyngeal (OPSCC) are subgroups of head neck carcinoma. E2F Transcription Factor 2 (E2F2) could contribute to cancer development, because it plays a critical role in many cellular processes, including the cycle, proliferation, differentiation, DNA damage response, death. In current study, we assessed associations five E2F2 polymorphisms (rs6667575, rs3218121, rs3218211, rs3218148, rs3218203) with OSCC OPSCC influence on TNM staging grading. This is...
Neuroendocrine neoplasms (NENs) constitute about 2% of all malignant neoplasms, and the angiogenesis process in these tumors is still a great interest. Vasohibin-1 (VASH-1) an inhibitor, while vascular endothelial growth factor A (VEGF-A) one main factors promoting formation. The subject this study was to assess serum concentration patients with diagnosed NEN control group. Methods. group consisted 120 NENs, 69 healthy volunteers. concentrations VASH-1 VEGF-A were tested using ELISA. We also...
Sarcomas are a heterogeneous group of mesenchymal tumours, with great variability in their clinical behaviour. While our knowledge sarcoma initiation has advanced rapidly recent years, relatively little is known about mechanisms progression. JUN-murine fibrosarcoma progression series consists four cell lines, JUN-1, JUN-2, JUN-2fos-3, and JUN-3. JUN-1 -2 were established from single tumour initiated H2K/v-jun transgenic mouse, JUN-3 originates different the same animal, JUN-2fos-3 results...