A5029753804- Retinal Development and Disorders
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Advanced Fluorescence Microscopy Techniques
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Veterinary Medicine and Surgery
- Cardiovascular Disease and Adiposity
- Cell Image Analysis Techniques
- Kruppel-like factors research
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Primate Behavior and Ecology
- Cancer-related gene regulation
- Photoreceptor and optogenetics research
- Bird parasitology and diseases
- Physiological and biochemical adaptations
- Advanced Biosensing Techniques and Applications
- Celiac Disease Research and Management
- HIV/AIDS drug development and treatment
- Food Allergy and Anaphylaxis Research
- AI in cancer detection
- Single-cell and spatial transcriptomics
German Centre for Cardiovascular Research
2020-2025
German Primate Center
2017-2024
Leipzig University
2013-2016
Abstract Cardiomyocytes can be implanted to remuscularize the failing heart 1–7 . Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated hypothesis that epicardial engineered muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes stromal cells structurally functionally chronically limiting effects in rhesus macaques. After confirmation of...
Significance Statement Nephropathologic analyses provide important outcomes-related data in the animal model studies that are essential to understanding kidney disease pathophysiology. In this work, authors used a deep learning technique, convolutional neural network, as multiclass histology segmentation tool evaluate models. This enabled rapid, automated, high-performance of digital whole-slide images periodic acid–Schiff–stained tissues, allowing high-throughput quantitative and...
Long non-coding RNAs (lncRNAs) can act as regulatory which, by altering the expression of target genes, impact on cellular phenotype and cardiovascular disease development. Endothelial lncRNAs their vascular functions are largely undefined. Deep RNA-Seq FANTOM5 CAGE analysis revealed lncRNA LINC00607 to be highly enriched in human endothelial cells. was induced response hypoxia, arteriosclerosis regression non-human primates, post-atherosclerotic cultured cells from patients also propranolol...
The retina encodes a broad range of stimuli, adapting its computations to features like brightness, contrast, or motion. However, it is unclear what extent also adapts spatial frequency content - as theories efficient coding would predict for instance, when switching between natural scenes and white noise. To address this, we analyzed neural activity marmoset retinal ganglion cells (RGCs) in response noise naturalistic movie stimuli. We trained linear-nonlinear models on both evaluated their...
Cardiovascular complications are the main cause of morbidity and mortality from diabetes. Herein, vascular inflammation is a major pathological manifestation. We previously characterized cardiac microvascular inflammatory phenotype in diabetic patients highlighted micro-RNA 92a (miR-92a) as driver endothelial dysfunction. In this article, we further dissect molecular underlying these findings by addressing anti-inflammatory Krüppel-like factors 2 4 (KLF2 KLF4). show that KLF2 dysregulation...
Abstract Background Common marmosets ( Callithrix jacchus ) are susceptible to gastrointestinal diseases. Sensitivity nutritional elements, for example gluten, has been suggested, but a serological screening not performed yet. Methods A gluten‐containing diet was offered 24 animals, followed by gluten‐free diet. During these diets, serum IgA antibodies gliadin (AGA), tissue transglutaminase (tTG), deamidated (ADGA), and glycoprotein 2 (AGP2A) were determined. Body weight, diarrhea, other...
The common marmoset (Callithrix jacchus, C. j.) is an established primate model in biomedical research and for human-related diseases. Monitoring of cardiovascular parameters including blood pressure (BP) important the health surveillance these experimental animals quantification diseases or pharmaceutical substances influencing BP. Measurement guidelines j. do not exist yet; therefore, present study was carried out to establish a practicable protocol based on recommendations American...
Abstract Background The increasing life span of Callithrix jacchus in combination with the occurrence metabolic and age‐dependent diseases requires improved health surveillance for this species. Methods status 56 marmosets was studied using a non‐invasive blood pressure (BP) device. Age‐, weight‐, sex‐dependent changes were analyzed. Four animals striking BP findings had follow‐up exams. Results Physiological pathological values could be defined. positively correlated age weight, while no...
Saccades are a fundamental part of natural vision. They interrupt fixations the visual gaze and rapidly shift image that falls onto retina. These stimulus dynamics can cause activation or suppression different retinal ganglion cells, but how they affect encoding information in types cells is largely unknown. Here, we recorded spiking responses to saccade-like shifts luminance gratings from isolated marmoset retinas investigated activity depended on combination presaccadic postsaccadic...
Abstract Retinal ganglion cells, the output neurons of vertebrate retina, often display nonlinear summation visual signals over their receptive fields. This creates sensitivity to spatial contrast, letting cells respond spatially structured stimuli, such as a contrast-reversing grating, even when no net change in overall illumination field occurs. Yet, computational models cell responses are based on linear Nonlinear extensions, other hand, subunit models, which separate fields into smaller,...
The social, health, and economic challenges of a steadily increasing aging population demand the use appropriate translational animal models to address questions like healthy aging, vaccination strategies, or potential interventions during process. Due their genetic proximity humans, especially nonhuman primates (NHPs) with relatively short generation period compared qualify as excellent for these purposes. common marmosets (Callithrix jacchus) in gerontology research increased over last...
Abstract The aim of this study was to establish a feasible and robust magnetic resonance imaging protocol for the quantitative assessment cardiac function in marmosets present normal values across different ages from young adult, middle-aged, very old clinically healthy animals. Cardiac MRI 33 anesthetized at age 2–15 years performed 9.4 T using IntraGate-FLASH that operates without any ECG-triggering breath holding. Normalized post-mortem heart weight, left ventricular end-diastolic volume...
Abstract The role of the vertebrate retina in early vision is generally described by efficient coding theory, which predicts that discards spatiotemporal correlations natural scenes. It unclear, however, whether predicted decorrelation activity ganglion cells, retina’s output neurons, holds under gaze shifts, dominate visual input. We here show species-specific patterns stimuli can drive strong and correlated spiking responses both within across distinct types cells marmoset as well mouse...
Abstract Background Diagnostic accuracy of endomyocardial biopsy could improve if clinically safe magnetic resonance (MR)-compatible bioptomes were available. We explored two novel MR-compatible cardiac for performance, safety, and clinical viability, employing in vivo minipig trials phase-contrast synchrotron radiation computed microtomography (SRµCT). Methods Analysis ex obtained pig biopsies was performed using SRµCT conventional two-dimensional histology. The technical performance...
The physiological aging process of the retina is accompanied by various and sometimes extensive changes: Macular degeneration, retinopathies glaucoma are most common findings in elderly can potentially lead to irreversible visual disablements up blindness. To study identify possible therapeutic targets counteract these diseases, use appropriate animal models mandatory. Besides commonly used rodent species, a non-human primate, marmoset (Callithrix jacchus) emerged as promising model human...
Heart failure is one of the most common causes morbidity and mortality. Both maturational abnormalities age-associated cardiac pathologies contribute to heart failure. Imaging-based assessment discern detailed structure at various stages imperative for understanding mechanisms behind growth aging. Using multiphoton nonlinear optical microscopy (NLOM) based label-free imaging, we investigated structural composition in a human-relevant aging model, marmoset monkey ( Callithrix jacchus )....
Although retinal organization is remarkably conserved, morphological anomalies can be found to different extents and varieties across animal species with each presenting unique characteristics patterns of displaced misplaced neurons. One the most widely used non-human primates in research, common marmoset (Callithrix jaccus) could potentially also interest for visual but unfortunately not well characterized this regard. Therefore, aim our study was provide a first time description structural...
ABSTRACT A standard circuit motif in sensory systems is the pooling of information from an upstream neuronal layer. downstream neuron thereby collects signals across different locations stimulus space, which together compose neuron’s receptive field. In addition, nonlinear transformations signal transfer between layers give rise to functional subunits inside For ganglion cells vertebrate retina, for example, field are thought correspond presynaptic bipolar cells. Identifying number and...
A standard circuit motif in sensory systems is the pooling of information from an upstream neuronal layer. downstream neuron thereby collects signals across different locations stimulus space, which together compose neuron’s receptive field. In addition, nonlinear transformations signal transfer between layers give rise to functional subunits inside For ganglion cells vertebrate retina, for example, field are thought correspond presynaptic bipolar cells. Identifying number and...
A standard circuit motif in sensory systems is the pooling of information from an upstream neuronal layer. downstream neuron thereby collects signals across different locations stimulus space, which together compose neuron’s receptive field. In addition, nonlinear transformations signal transfer between layers give rise to functional subunits inside For ganglion cells vertebrate retina, for example, field are thought correspond presynaptic bipolar cells. Identifying number and...
Spatially nonlinear stimulus integration by retinal ganglion cells lies at the heart of various computations performed retina. It arises from transmission signals that receive bipolar cells, which thereby constitute functional subunits within a cell's receptive field. Inferring these recorded cell activity promises new avenue for studying architecture This calls efficient methods, leave sufficient experimental time to leverage acquired knowledge further investigating identified subunits....
Abstract The role of the vertebrate retina in early vision is generally described by efficient coding hypothesis 1,2 , which predicts that reduces redundancy inherent natural scenes 3 discarding spatiotemporal correlations while preserving stimulus information 4 . It unclear, however, whether predicted decorrelation and reduction activity ganglion cells, retina’s output neurons, hold under gaze shifts, dominate dynamics visual input 5 We show here species-specific patterns stimuli can drive...
Abstract Humans and other primates have specialized visual pathways composed of interconnected cortical areas. The input area V1 contains neurons that encode basic features, whereas downstream in the lateral prefrontal cortex (LPFC) acquire tuning for novel complex feature associations. It has been assumed each is repeatable neuronal subtypes, variations synaptic strength connectivity patterns underlie functional specialization. Here we test hypothesis diversity intrinsic make-up single...