A5019814780- Neural dynamics and brain function
- Stress Responses and Cortisol
- Neural Networks and Applications
- Neuroscience and Neuropharmacology Research
- Advanced Memory and Neural Computing
- Neural Networks and Reservoir Computing
- stochastic dynamics and bifurcation
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Retinal Development and Disorders
Western University
2022-2025
The elevation of glucocorticoids is a hallmark stress, arising from the integration rapid neuronal signals into sustained hormonal outputs. A key interface for this neuroendocrine signal translation corticotropin releasing hormone (CRH) neurons in paraventricular nucleus hypothalamus (PVN), which release CRH at median eminence (ME). We recently discovered that PVN exhibit characteristic shift firing patterns rhythmic short-bursts (low-activity state) to tonic (high-activity response stress....
Abstract Networks throughout physics and biology leverage spatiotemporal dynamics for computation. However, the connection between structure computation remains unclear. Here, we study a complex-valued neural network (cv-NN) with linear interactions phase-delays. We report cv-NN displays sophisticated dynamics, which then use, in combination nonlinear readout, The can instantiate dynamics-based logic gates, encode short-term memories, mediate secure message passing through of computations...
The stress response necessitates an immediate boost in vital physiological functions from their homeostatic operation to elevated emergency response. However, the neural mechanisms underlying this state-dependent change remain largely unknown. Using a combination of vivo and ex electrophysiology with computational modeling, we report that corticotropin releasing hormone (CRH) neurons paraventricular nucleus hypothalamus (PVN), effector hormonal response, rapidly transition between distinct...
Abstract Recordings of cortical neurons isolated from brain slices and dissociated their networks, display intrinsic spike frequency adaptation (I-SFA) to a constant current input. Interestingly, extracellular recordings in behaving subjects also show extrinsic-SFA (E-SFA) response sustained visual stimulation. Because are networks slice recordings, it is challenging infer how I-SFA contributes E-SFA interconnected brains during behavior. To investigate this, we recorded responses macaque...
Abstract Humans and other primates have specialized visual pathways composed of interconnected cortical areas. The input area V1 contains neurons that encode basic features, whereas downstream in the lateral prefrontal cortex (LPFC) acquire tuning for novel complex feature associations. It has been assumed each is repeatable neuronal subtypes, variations synaptic strength connectivity patterns underlie functional specialization. Here we test hypothesis diversity intrinsic make-up single...
We study a complex-valued neural network (cv-NN) with linear, time-delayed interactions. report the cv-NN displays sophisticated spatiotemporal dynamics, including partially synchronized ``chimera'' states. then use these in combination nonlinear readout, for computation. The can instantiate dynamics-based logic gates, encode short-term memories, and mediate secure message passing through of interactions time delays. computations this system be fully described an exact, closed-form...
ABSTRACT The stress response necessitates an immediate boost in vital physiological functions from their homeostatic operation to elevated emergency response. However, neural mechanisms underlying this state-dependent change remain largely unknown. Using a combination of vivo and ex electrophysiology with computational modeling, we report that corticotropin releasing hormone (CRH) neurons the paraventricular nucleus hypothalamus (PVN), effector hormonal response, rapidly transition between...