A5022934293- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neural Networks and Applications
- Visual perception and processing mechanisms
- stochastic dynamics and bifurcation
- Neuroscience and Neural Engineering
- interferon and immune responses
- Neuroscience of respiration and sleep
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Multisensory perception and integration
- Tactile and Sensory Interactions
- CCD and CMOS Imaging Sensors
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
Western University
2018-2025
Robarts Clinical Trials
2019-2022
Division of Undergraduate Education
2018
Preys use their memory – where they sensed a predatory threat and whether safe shelter is nearby to dynamically control survival instinct avoid harm reach safety. However, it remains unknown which brain regions are involved, how such top-down of innate behavior implemented at the circuit level. Here, using adult male mice, we show that anterior hypothalamic nucleus (AHN) best positioned this task as an exclusive target hippocampus (HPC) within medial defense system. Selective optogenetic...
Key points The hypothalamic‐pituitary‐adrenal (HPA) axis habituates to repeated stress exposure. We studied hypothalamic corticotropin‐releasing hormone (CRH) neurons that form the apex of HPA in a mouse model habituation using restraint. intrinsic excitability CRH decreased after time course coincided with development habituation. This plasticity co‐developed an expansion surface membrane area, which increased passive electric load and dampened depolarization response influx positive...
Glutamatergic synaptic inputs to corticotrophin-releasing hormone (CRH) secreting neurons in the paraventricular nucleus of hypothalamus (PVN) are required for stress-induced activation hypothalamic-pituitary-adrenal (HPA) axis. These synapses also undergo plasticity, thereby influencing HPA axis stress adaptation. By using patch clamp electrophysiology, we show that, adult non-stressed mice, action potentials at these glutamatergic afferents elicit multiquantal transmission postsynaptic...
Following the loss of a sensory modality, such as deafness or blindness, crossmodal plasticity is commonly identified in regions cerebrum that normally process deprived modality. It has been hypothesized significant changes patterns cortical afferent and efferent projections may underlie these functional changes. However, studies thalamocortical corticocortical connections have refuted this hypothesis, instead revealing profound resilience following blindness. This report first study outputs...
Abstract The importance of chromatin-mediated processes in neurodevelopmental and intellectual disability disorders is well recognised. However, how chromatin dysregulation glial cells impacts cognitive abilities less understood. Here, we demonstrate that targeted loss the ATRX remodeler microglia alters accessibility profiles, leading to de-repression endogenous retroelements, triggering viral mimicry. Functionally, find microglial deficiency electrophysiological properties hippocampal...
Abstract Recordings of cortical neurons isolated from brain slices and dissociated their networks, display intrinsic spike frequency adaptation (I-SFA) to a constant current input. Interestingly, extracellular recordings in behaving subjects also show extrinsic-SFA (E-SFA) response sustained visual stimulation. Because are networks slice recordings, it is challenging infer how I-SFA contributes E-SFA interconnected brains during behavior. To investigate this, we recorded responses macaque...
Abstract Humans and other primates have specialized visual pathways composed of interconnected cortical areas. The input area V1 contains neurons that encode basic features, whereas downstream in the lateral prefrontal cortex (LPFC) acquire tuning for novel complex feature associations. It has been assumed each is repeatable neuronal subtypes, variations synaptic strength connectivity patterns underlie functional specialization. Here we test hypothesis diversity intrinsic make-up single...
In the central nervous system, a pair of neurons often form multiple synaptic contacts and/or functional neurotransmitter release sites (synaptic multiplicity). Synaptic multiplicity is plastic and changes throughout development in different physiological conditions, being an important determinant for efficacy transmission. Here, we outline experiments estimating degree synapses terminating onto given postsynaptic neuron using whole-cell patch clamp electrophysiology acute brain slices....
In the central nervous system, a pair of neurons often form multiple synaptic contacts and/or functional neurotransmitter release sites (synaptic multiplicity). Synaptic multiplicity is plastic and changes throughout development in different physiological conditions, being an important determinant for efficacy transmission. Here, we outline experiments estimating degree synapses terminating onto given postsynaptic neuron using whole-cell patch clamp electrophysiology acute brain slices....
Visual neurons in many brain areas show non-linear response profiles as a function of the stimulus shown inside their receptive fields. These can be fit with different functions to obtain tuning curve neuron for particular feature. One example is contrast function, e.g., increases neuron’s field produce changes its profile that fitted by sigmoid function. Such properties have been attributed lateral inhibition and normalization within network interconnected neurons. Here we test hypothesis...
Abstract Preys use their memory - where they sensed a predatory threat and whether safe shelter is nearby to dynamically control survival instinct avoid harm reach safety. However, it remains unknown which brain regions are involved, how such top-down of innate behaviour implemented at the circuit level. Here, we show that anterior hypothalamic nucleus (AHN) best positioned perform this task as an exclusive target hippocampus (HPC) within medial defense system. Selective optogenetic...