A5103170493- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neural Networks and Applications
- stochastic dynamics and bifurcation
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Adipose Tissue and Metabolism
Western University
2024-2025
London Health Sciences Centre
2024-2025
Transnational Press London
2024
Western Institute For Biomedical Research
2024
Western University of Health Sciences
2024
The elevation of glucocorticoids is a hallmark stress, arising from the integration rapid neuronal signals into sustained hormonal outputs. A key interface for this neuroendocrine signal translation corticotropin releasing hormone (CRH) neurons in paraventricular nucleus hypothalamus (PVN), which release CRH at median eminence (ME). We recently discovered that PVN exhibit characteristic shift firing patterns rhythmic short-bursts (low-activity state) to tonic (high-activity response stress....
Neuronal populations can expand their information encoding capacity using mixed selective neurons. This is particularly prominent in association areas such as the Lateral Prefrontal Cortex (LPFC) that integrate from multiple sensory systems. During naturalistic conditions where subjects have agency, it unclear how LPFC neuronal ensembles process space and time varying information. Here we show during a virtual navigation task requires associative memory decision making, individual neurons...
Background: The lateral prefrontal cortex (LPFC) is uniquely found in primates and has been associated with contextual learning. This function thought to be subserved by neurons that are tuned abstract concepts the combination of those concepts. LPFC neuron tuning remains fully investigated naturalistic conditions. Methods: Two macaques were trained perform a context-colour association task while using joystick navigate an X-shaped maze. They implanted two 96-channel microelectrode arrays,...
Abstract Recordings of cortical neurons isolated from brain slices and dissociated their networks, display intrinsic spike frequency adaptation (I-SFA) to a constant current input. Interestingly, extracellular recordings in behaving subjects also show extrinsic-SFA (E-SFA) response sustained visual stimulation. Because are networks slice recordings, it is challenging infer how I-SFA contributes E-SFA interconnected brains during behavior. To investigate this, we recorded responses macaque...
Background: Brain-machine-interface research has utilized multichannel single neuron recordings to decode movement intention. However, the prefrontal cortex (PFC) contains mental representations of more abstract task and goal elements which may be as important signals in a brain-machine-interface. We therefore virtual reality simulate real-world while recording from ensembles primate PFC neurons. Methods: Two male rhesus macaques (macaca mulatta) were trained navigate environment using...