A5101927234- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Neuroendocrine Tumor Research Advances
- HIV-related health complications and treatments
- Bacterial Identification and Susceptibility Testing
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroblastoma Research and Treatments
- Long-Term Effects of COVID-19
- Hemodynamic Monitoring and Therapy
- SARS-CoV-2 detection and testing
- HIV Research and Treatment
- Clostridium difficile and Clostridium perfringens research
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- COVID-19 Impact on Reproduction
- Healthcare Systems and Reforms
- Respiratory viral infections research
- Mechanical Circulatory Support Devices
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Healthcare Policy and Management
- Antibiotic Use and Resistance
- Vaccine Coverage and Hesitancy
- Antibiotics Pharmacokinetics and Efficacy
Cornell University
2016-2025
Weill Cornell Medicine
2016-2025
NewYork–Presbyterian Hospital
2011-2024
Presbyterian Hospital
2011-2024
New York Hospital Queens
2011-2024
Graphic Era University
2024
University Hospitals Birmingham NHS Foundation Trust
2014-2023
Lower Manhattan Hospital
2021-2022
Queen Elizabeth Hospital Birmingham
2012-2022
INHS Asvini
2022
Abstract The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies suggested that the antibody content could influence patient outcomes. We conducted an open-label, trial adults with COVID-19 receiving oxygen within 12 d respiratory symptom onset ( NCT04348656 ). Patients were allocated 2:1 to 500 ml or standard care. composite primary outcome was intubation death by 30...
Abstract Diagnostic stewardship seeks to improve ordering, collection, performance, and reporting of tests. Test results play an important role in reportable HAIs. The inclusion HAIs public pay for performance programs has highlighted the value diagnostic as part infection prevention initiatives. Inappropriate testing should be discouraged, approaches that seek alter solely impact a metric avoided. HAI definitions further adapted new technologies, with focus on actionable clinically relevant...
With a rising incidence of COVID-19–associated morbidity and mortality worldwide, it is critical to elucidate the innate adaptive immune responses that drive disease severity. We performed longitudinal profiling peripheral blood mononuclear cells from 45 patients healthy donors. observed dynamic landscape in progression absolute changes lymphocyte myeloid severe versus mild cases or controls. Intubation death were coupled with selected natural killer cell KIR receptor usage IgM+ B associated...
Abstract Background Over testing is a common problem that impacts patient safety and quality. Less frequent, yet expensive tests, such as CMV, HBV, HCV resistance are frequently ordered inappropriately. Inappropriate ordering of these tests can lead to waste (unused test), false positives, unnecessary cost. Diagnostic stewardship promotes the judicious use enhance care curb expenses.Table 1:Summary Inappropriate/Total # per Medical unit Campus Number inappropriate vs total number orders...
Abstract Background Obtaining a urine culture (UCx) in the absence of urinary symptoms and inflammation has been shown to result misdiagnosis over treatment tract infections (UTIs) catheter-associated UTIs adults. Reflex UCx is diagnostic stewardship strategy reduce unnecessary by performing only if urinalysis (UA) meets criteria for infection. Although AAP recommendations reflex pediatrics, there are little data support this approach. We aimed assess potential impact on reducing children....
Serum antibody decay following RSV infection in adults was examined to evaluate the durability of immune response. Twenty subjects with and 10 who remained uninfected had blood samples obtained over 16–25 months analyzed by microneutralization assay enzyme immunoassay. The mean titers infected rose approximately eightfold post-infection. rate decline −0.20 log 2 titer per month which led a ≥fourfold drop 75% at 1 year. In contrast, were relatively stable. partial immunity resulting from...
Antiretroviral therapy has enabled people to live long lives with human immunodeficiency virus (HIV). As a result, most HIV-infected adults in the United States are >50 years of age. In light this changing epidemiology, HIV providers must recognize and manage multiple comorbidities aging-related syndromes. Geriatric principles can help meet new challenge, as preservation function optimization social psychological health relevant care aging adults, even those who not yet old. Nonetheless,...
OBJECTIVES: To evaluate the cause and prognosis of hyperdynamic left ventricular ejection fraction in critically ill patients with sepsis. DESIGN: Retrospective, single-center cohort study. SETTING: University Hospital ICU, Birmingham, United Kingdom. PATIENTS: ICU who received a transthoracic echocardiogram within 7 days sepsis between April 2016 December 2019. INTERVENTION: None. MEASUREMENTS AND MAIN RESULTS: The 90-day mortality rates normal (55–70%), depressed (< 55%), (> 70%)...
Abstract Background Secondary vancomycin prophylaxis (VP) is one strategy to reduce recurrent C. difficile infection (CDI). Clinical decision support (CDS) was implemented in the electronic health record (Epic®) 2020 remind providers about eligibility for VP at time of prescription broad-spectrum antibiotics patients with a history CDI. The effectiveness this assessed. CDIFF BPA Prophylaxis Best Practice Alert Methods Retrospective review an interruptive best practice alert (BPA) 8 hospitals...
Abstract Background Mild cognitive impairment (MCI) is a neurocognitive state between normal aging and dementia, with evidence of neuropsychological changes but insufficient functional decline to warrant diagnosis dementia. Individuals MCI are at increased risk for progression dementia; an appreciable proportion display neuropsychiatric symptoms (NPS), also known factor Cerebrovascular disease (CVD) thought be underdiagnosed contributor MCI/dementia. The Ginkgo biloba extract, EGb 761 ® ,...
Deep understanding of the SARS-CoV-2 effects on host molecular pathways is paramount for discovery early biomarkers outcome coronavirus disease 2019 (COVID-19) and identification novel therapeutic targets. In that light, we generated metabolomic data from COVID-19 patient blood using high-throughput targeted nuclear magnetic resonance (NMR) spectroscopy high-dimensional flow cytometry. We find considerable changes in serum metabolome composition patients associated with severity, response to...
Carcinoid heart disease (NET-CHD) is associated with the development of symptom-limited exercise capacity and high rates morbidity mortality.This study sought to determine survival, cardiac function, functional class following surgery.This was a retrospective observational cohort between 2005 2015 at European Centre Excellence for Neuroendocrine Tumours, Queen Elizabeth Hospital Birmingham. England consisting 62 consecutive patients referred NET-Cardiology Service.Subjects were assessed...
Diarrhea is common and associated with substantial morbidity among hematopoietic cell transplant (HCT) recipients, but the etiology often not identified. Multiplexed polymerase chain reaction (PCR) assays increase detection of diarrheal pathogens, impact this technology in population has been evaluated.Our center replaced stool cultures other conventional microbiologic methods FilmArray Gastrointestinal Panel (GI PCR) June 2016. We reviewed all adult patients who received an HCT from...
Abstract Purpose To share challenges and opportunities for antimicrobial stewardship programs based on one center’s experience during the early weeks of coronavirus disease 2019 (COVID-19) pandemic. Summary In spring 2020, New York City quickly became a hotspot COVID-19 pandemic in United States, putting strain local healthcare systems. Antimicrobial faced diagnostic therapeutic uncertainties as well resource challenges. With lack effective antivirals, antibiotic use critically ill patients...
HIV-infected and HIV-exposed, uninfected infants experience a high burden of infectious morbidity mortality. Hospitalization is an important metric for associated with mortality, yet, little known about rates causes hospitalization among these in the first 12 months life. Using data from prevention mother-to-child transmission (PMTCT) trial (India SWEN), where HIV-exposed breastfed were given extended nevirapine, we measured 12-month infant all-cause cause-specific risk factors. Among 737...
This report describes how the NYC Department of Health and Mental Hygiene conducted sentinel surveillance influenza-like symptoms genetic sequencing to characterize community transmission determine geographic origin SARS-CoV-2 infections.
ABSTRACT Rhodotorula is an emerging opportunistic fungal pathogen that rarely reported to cause endocarditis. We describe a case involving patient who developed endocarditis due mucilaginosa and Staphylococcus epidermidis , proven by culture histopathology. The illustrates the unique diagnostic therapeutic challenges relevant spp.
With a rising incidence of COVID-19-associated morbidity and mortality worldwide, it is critical to elucidate the innate adaptive immune responses that drive disease severity. We performed longitudinal profiling peripheral blood mononuclear cells from 45 patients healthy donors. observed dynamic landscape in progression absolute changes lymphocyte myeloid severe versus mild cases or controls. Intubation death were coupled with selected natural killer cell KIR receptor usage IgM+ B associated...
Computed tomography has become established as complementary to aortography in the investigation of patients with suspected aortic dissection. Two cases dissecting aneurysm are reported which extensive failed show evidence In both dissection was demonstrated by computed tomography. The diagnosis confirmed one case at operation and other follow up. It is suggested that diagnostic method first choice
Disease-specific stress can partly explain Sickle Cell Disease (SCD) healthcare utilization. We developed and validated two measures of adult SCD-specific for research clinical care. A large cohort adults with SCD completed both the 3-item Likert-scale adapted from a previous disease measure 10-item questionnaire drafted specifically to stress. They concurrently psychosocial health-related quality life scale battery, then subsequently daily pain diaries. Diaires measured: intensity, distress...