A5015941558- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- Plant Disease Resistance and Genetics
- Antifungal resistance and susceptibility
- Parkinson's Disease and Spinal Disorders
- Hereditary Neurological Disorders
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Erythrocyte Function and Pathophysiology
- Endometrial and Cervical Cancer Treatments
- Ion channel regulation and function
- Pituitary Gland Disorders and Treatments
- Cancer Treatment and Pharmacology
- Advanced Neuroimaging Techniques and Applications
- Plant tissue culture and regeneration
- Fish Ecology and Management Studies
- Physiological and biochemical adaptations
- Autoimmune Neurological Disorders and Treatments
- Bone Tissue Engineering Materials
- Cervical Cancer and HPV Research
- Metabolism and Genetic Disorders
- Thyroid and Parathyroid Surgery
- Osteoarthritis Treatment and Mechanisms
- Autism Spectrum Disorder Research
- Neurological diseases and metabolism
Nara Medical University
2018-2024
Kanazawa University
2013-2023
University of the Punjab
2023
University of Oxford
2023
National Hospital Organization
2022
Kanazawa Medical Center
2022
Ishikawa Prefectural Nursing University
2022
Kudanzaka Hospital
2022
University of Alabama at Birmingham
2020
George Washington University
2020
Thymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence its benefit. We conducted multicenter, randomized trial comparing thymectomy plus prednisone with alone.We compared extended transsternal alternate-day alone. Patients 18 to 65 years age who had generalized nonthymomatous gravis disease duration less than 5 were included if they Myasthenia Gravis Foundation America clinical class II IV (on scale from I V, higher classes indicating more...
Summary To date, six candidate genera of anaerobic ammonium‐oxidizing (anammox) bacteria have been identified, and numerous studies conducted to understand their ecophysiology. In this study, we examined the physiological characteristics an anammox bacterium in genus ‘ C andidatus J ettenia’. Planctomycete KSU ‐1 was found be a mesophilic (20–42.5°C) neutrophilic ( pH 6.5–8.5) with maximum growth rate 0.0020 h −1 . cells showed typical structural features bacteria; i.e. 29 N 2 gas production...
Palladium nanoparticles covered with liquid-crystal molecules were prepared by UV irradiation of an alcohol solution palladium(II) acetate in the presence molecules. The Pd have average diameter 2.5 nm. A twisted nematic (TN) device (LCD) was fabricated doping another kind In this sign dielectric anisotropy (Δε) molecules, which cover nanoparticles, is opposite to that work as host (Δε>0). TN-LCD cell research exhibits a frequency modulation response applied alternative voltage wave form.
<h3>Objectives</h3> To evaluate the ability of tacrolimus to reduce corticosteroid dose in patients with myasthenia gravis (MG) and drug9s safety a double-blind, placebo-controlled, parallel group study. <h3>Methods</h3> Patients being treated oral prednisolone at doses equivalent 10–20 mg/day, stable symptoms, were randomised or placebo 28-week double-blind The was tapered procedures specified protocol. primary efficacy endpoint mean daily given last 12 weeks <h3>Results</h3> Eighty...
Fatigue is a multidimensional phenomenon. Although psychological tests can be used to evaluate subjective fatigue, an objective measurement of fatigue needed mental, physical, and occupational health inform appropriate interventions. Heart rate variability (HRV) has emerged as potential candidate for assessing mental fatigue; however, its effectiveness safety remain inconclusive. To address these, we conducted single-center, randomized trial compare the efficacy HRV with evaluating fatigue....
Transport system xc− is a member of plasma membrane heterodimeric amino-acid transporters and consists two protein components, xCT 4F2hc. This mediates cystine entry coupled with the exodus intracellular glutamate regulates glutathione (GSH) levels in most mammalian cultured cells. We studied activity GSH content human ovarian cancer cell line (A2780) its cisplatin (CDDP)-resistant variant (A2780DDP). The rate uptake was approximately 4.5-fold higher A2780DDP cells than A2780 mediated by...
Objective To study the updated prevalence and clinical features of myasthenia gravis (MG) in Japan during 2017. Methods We sent survey sheets to randomly selected medical departments (number = 7,545). First, we asked number MG patients who visited from January 1, 2017, December 31, Then, second sheet that answered first obtain information received diagnosis between 2015, Results The answer were 2,708 (recovery rate: 35.9%). After all, 100,000 population was estimated as 23.1 (95%CI:...
Objective. Numerous cytokines are expressed in lesions of synovial hyperplasia patients with rheumatoid arthritis (RA), and their pathophysiological contributions have been the subject speculation. These genes regulated by transcription factor NFκB which turn is activated tumour necrosis factor‐α (TNF‐α) cytokines. In this study we examined inhibition production pro‐inflammatory cytokines, adhesion molecule matrix metalloproteinase (MMP) from tissue RA introduction synthetic double‐stranded...
Abstract We have screened genes predominantly expressed in the rat spinal cord, and we report here cloning of most abundant unknown gene. It is a novel member central nervous system (CNS) myelin-constituting proteins, myelin-associated oligodendrocytic basic protein (MOBP). MOBP abundantly specifically oligodendrocytes at mRNA level only next to myelin (MBP) proteolipid protein. Two isoforms been confirmed. One them has proline-rich tandem repeats 84% homology with human counterpart terms...
To identify clinical and electrophysiologic features related to IV immunoglobulin (IVIg) responsiveness in chronic inflammatory demyelinating polyneuropathy (CIDP), the authors conducted a multicenter study on 312 patients with CIDP (199 responders 113 nonresponders). Muscle atrophy decreased compound muscle action potential were pronounced nonresponders of IVIg. Male gender, longer disease duration, slow progression symptoms also associated IVIg unresponsiveness. Features suggesting axonal...
A randomized controlled trial has been started in Japan to compare the utility of palliative chemotherapy containing paclitaxel and carboplatin (TC) with cisplatin (TP) as a standard treatment for patients newly diagnosed Stage IVB, persistent or recurrent cervical cancer who are not amenable curative local therapy. This was designed evaluate non-inferiority TC measured by number hospitalized days an indicator quality life (QOL) when compared TP combination The primary endpoint is overall...
Anti-ryanodine receptor (RyR) antibodies were measured in sera from 33 myasthenia gravis (MG) patients using three peptides the human RyR1 sequence, two C-terminal included functional calcium release channel, and an N-terminal peptide implicated ion-conduction. Antibodies more frequently positive against peptides, particularly thymoma-associated MG. In a preliminary open trial with FK506, immunosuppressant enhancer of RyR-related sarcoplasmic release, authors observed sustained benefits...
We studied myocardial 123 I-metaiodobenzylguanidine (MIBG) accumulation in 12 patients with Parkinson's disease (PD). MIBG is an analog of norepinephrine (NE) and a tracer for sympathetic neuron integrity function. uptake the myocardium was significantly lower PD than controls. The heart to mediastinum ratio (H/M) calculated by using average count per pixel mediastinum. In PD, H/M controls (P<0.0001), while washout higher (P<0.001). A decrease observed early stage PD. This suggests that...
In autism spectrum disorder (ASD), the complexity-specific hypothesis explains that atypical visual processing is attributable to selective functional changes in pathways. We investigated dendritic microstructures and their associations with connectivity (FC). Participants included 28 individuals ASD 29 typically developed persons. explored neurite orientation dispersion density imaging (NODDI) brain areas whose FC was significantly correlated NODDI parameters regions of interests....
Inadequate dietary habits in youth are known to increase the risk of onset various diseases adulthood. Previously, we found that female college students who skipped breakfast had higher incidences dysmenorrhea, suggesting skipping interferes with ovarian and uterine functions. Since can be managed by education, it is preferable establish a convenient screening system for meal associated dysmenorrhea as part routine services health service centers. In this study, recruited 3172 aged from 18...
We fabricated a tunable birefringent (TB) mode nematic liquid-crystal (NLC) electrooptic device using NLC-K15 (Merck) as host NLC (called NLC-1), where the cell is doped with Pd nanoparticles covered (NLC-2) molecules, having cyano group such 5CB positive dielectric anisotropy (Δε>0) or CCN-47 negative Δε (Δε<0). The diameter of core particle 2.5 nm and concentration 1 wt%. TB LCD in this way exhibits remarkable frequency modulation response below 100 Hz driving voltage waveform. It...