A5052055241- Palliative Care and End-of-Life Issues
- Amyotrophic Lateral Sclerosis Research
- Peripheral Neuropathies and Disorders
- Nerve Injury and Rehabilitation
- Peripheral Nerve Disorders
- Cerebrospinal fluid and hydrocephalus
- Botulinum Toxin and Related Neurological Disorders
- Healthcare Decision-Making and Restraints
- Voice and Speech Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Myasthenia Gravis and Thymoma
- Dysphagia Assessment and Management
- Neurogenetic and Muscular Disorders Research
- Glioma Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Hereditary Neurological Disorders
- Viral Infections and Immunology Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Spinal Hematomas and Complications
- Viral Infections and Vectors
- Coenzyme Q10 studies and effects
- Mind wandering and attention
- Musculoskeletal synovial abnormalities and treatments
- Neurology and Historical Studies
- Blood disorders and treatments
University of Ottawa
2015-2024
Ottawa Hospital
2015-2024
Ottawa Hospital Research Institute
2017-2024
Children's Hospital of Eastern Ontario
2016-2023
McGill University
2023
Deleted Institution
2023
Bruyère
2019
University of North Carolina Wilmington
2018
Ottawa University
2017
Cleveland Clinic
2002
Importance Treatment options for amyotrophic lateral sclerosis (ALS) remain suboptimal. Results from a phase 2 study of reldesemtiv in ALS suggested that it may slow disease progression. Objective To assess the effect vs placebo on functional outcomes ALS. Design, Setting, and Participants A Study to Evaluate Efficacy Safety Reldesemtiv Patients With Amyotrophic Lateral Sclerosis (COURAGE-ALS) was double-blind, placebo-controlled 3 randomized clinical trial conducted at 83 centers 16...
To describe health care service utilization and cost for decedents with without amyotrophic lateral sclerosis (ALS) in the last year of life.Using linked administrative data, we conducted a retrospective, population-based cohort study Ontario, Canada, from 2013 to 2015. We examined demographic rate utilization, services life.We identified 283,096 whom 1,212 (0.42%) had ALS. Decedents ALS spent 3 times as many days an intensive unit (ICU) (mean 6.3 vs 2.1, p < 0.001), twice using complex...
Coenzyme Q10 (CoQ10) is an important electron carrier and antioxidant. The COQ7 enzyme catalyzes the hydroxylation of 5-demethoxyubiquinone-10 (DMQ10), second-to-last step in CoQ10 biosynthesis pathway. We report a consanguineous family presenting with hereditary motor neuropathy associated homozygous c.1A > G p.? variant abnormal biosynthesis.Affected members underwent clinical assessments that included nerve conduction testing, histologic analysis, MRI. Pathogenicity was assessed cultured...
Abstract The magnetic resonance imaging findings in a case of transient cortical blindness (TCB) after cardiac catheterization are described for the first time. In addition, literature review TCB, comparison with reversible posterior leukoencephalopathy, and hypothesis regarding pathophysiology TCB presented. Cathet Cardiovasc Intervent 2002;57:47–49. © 2002 Wiley‐Liss, Inc.
Laryngospasm is an involuntary, sustained closure of sphincter musculature that leads to unpleasant subjective experience dyspnea and choking. It underreported symptom in amyotrophic lateral sclerosis (ALS). In this study we aimed better characterize the prevalence clinical characteristics laryngospasm ALS patients.The medical records 571 patients with followed between 2008 2018 were searched for evidence laryngospasm. A total 23 identified data related patient extracted.Laryngospasm was...
Evidence of spinal cord involvement in Powassan virus infection is largely limited to mouse models. We report a case polio-like illness caused by 62-year-old man Canada. Magnetic resonance imaging showed T2 hyperintensities the anterior horns cervical cord.
Primitive neuroectodermal tumors (PNETs) are typically present as masses in children and adolescents, but rarely adults. Diagnoses, management strategies, prognostication factors not well established adult cases of PNETs. We describe the case a central nervous system PNET diagnosed 55-year-old woman presenting with sudden onset symptoms consisting increased intracranial pressure findings diffuse leptomeningeal enhancement small medullary lesion seen on MRI. Amongst database PNETs adults, our...
Background: The end-of-life period is associated with disproportionately higher health care utilization and cost at the population level but there little data in Parkinson’s disease (PD). Objective: goals of this study were to 1) compare use last year life between decedents without PD, 2) identify factors palliative consultation death hospital. Methods: Using linked administrative datasets held ICES, we conducted a retrospective, population-based cohort all Ontario, Canada from 2015 2017. We...
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Many patients with amyotrophic lateral sclerosis (ALS) receive palliative care (PC) very late or not at all. The impact of PC on ALS and caregivers has been quantified. Study goals included (1) measuring the early quality life mood patients/caregivers (2) describing patient/caregiver satisfaction PC.The study was a non-randomized, prospective feasibility being treated Ottawa Hospital Clinic their caregivers. Exclusion criteria were age < 18 years, inability to complete questionnaires, prior...
Mood changes following ingestion of dextroamphetamine (D-AMP) or methylphenidate (MPH) were examined in 40 narcoleptic patients. The Profile Status (POMS) and eight additional adjectives describing feelings used to quantify mood before taking stimulant medication approximately 90 minutes after medication. No significant differences found between the effects two stimulants. When data from D-AMP MPH combined, significantly higher ratings on POMS factor Vigour-Activity 'confident', 'talkative'...
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Myelodysplastic syndromes (MDSs) are a heterogeneous group of disorders negatively affecting the bone marrow and resulting in multiple cytopenias. MDS ultimately progresses to acute myeloid leukemia (AML). Azacitidine was first hypomethylating agent approved Canada for patients with high risk AML 20-30% blasts. has relatively low toxicity profile is well tolerated by most age groups. We conducted retrospective chart review who received azacitidine at our institution, over 3.5-year period. To...
Pulmonary function testing is a standard part of care for patients admitted to hospital with myasthenia gravis exacerbation. It may inform clinicians' decisions intubate patients. known that pulmonary declines age in healthy adults. We studied the effect on and serious respiratory events, including intubation, exacerbation.Single center, retrospective cohort consecutive treated Demographics, tests (PFTs), events requiring intubation or emergency therapy were recorded each encounter....
Painless enlargement of the neck is most often due to adiposity, goiter, or lymphadenopathy. The figure, A, demonstrates how diffuse hypertrophy cervical spinal nerves and trunks can also produce a clinically obvious increase in circumference. Acknowledgment: authors thank Janine Klaas for clinical photography.
A 73-year-old man presented with sudden right-sided weakness, aphasia, and low-grade headache. Medical history was pertinent for obstructive sleep apnea, hypertension, diabetes, dyslipidemia, which he appropriately treated, in addition to taking aspirin primary prevention. Initial bloodwork, head CT, vessel imaging were normal. MRI showed a nonenhancing, nonrestricting T2 hyperintensity the left temporal lobe, multiple microhemorrhages (figure 1, B). Symptoms resolved within 24 hours...