Nicholas Olney
A5039162922- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Cholinesterase and Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Tuberous Sclerosis Complex Research
- Neurological diseases and metabolism
- Pharmacological Receptor Mechanisms and Effects
- biodegradable polymer synthesis and properties
- Dermatological and Skeletal Disorders
- Biochemical Acid Research Studies
- Brain Tumor Detection and Classification
- Health Systems, Economic Evaluations, Quality of Life
- Caveolin-1 and cellular processes
- Protist diversity and phylogeny
- Tumors and Oncological Cases
- Dysphagia Assessment and Management
- Plant-based Medicinal Research
- Histiocytic Disorders and Treatments
- Cervical and Thoracic Myelopathy
- Infant Health and Development
- Lipid metabolism and biosynthesis
- Geriatric Care and Nursing Homes
- Neurobiology of Language and Bilingualism
Oregon Clinic
2025
Barrow Brain and Spine
2022-2024
Providence College
2022-2024
Providence Portland Medical Center
2023-2024
Providence Health & Services
2019-2022
University of California, San Francisco
2010-2020
University Memory and Aging Center
2010-2019
Foundation for Psychocultural Research
2016
Genomics Institute of the Novartis Research Foundation
2007
Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops through largely unknown mechanisms. TRPA1, Transient Receptor Potential ion channel, sensor pungent chemicals may play role in acute noxious mechanosensation and cold thermosensation. We have developed specific small molecule TRPA1 inhibitor (AP18) can reduce cinnameldehyde-induced nociception vivo. Interestingly, AP18 capable reversing CFA-induced mechanical mice. Although TRPA1-deficient mice develop...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with motor neuron loss as defining feature. Despite significant effort, therapeutic breakthroughs have been modest. MN-166 (ibudilast) has demonstrated neuroprotective action by various mechanisms: inhibition of proinflammatory cytokines and macrophage migration inhibitory factor, phosphodiesterase inhibition, attenuation glial cell activation in models ALS. Early-phase studies suggest that may improve survival outcomes slow...
Importance The etiology of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, is unknown. However, neuroinflammation and complement activation may play role in disease progression. Objective To determine the effects zilucoplan, an inhibitor C5, individuals with ALS. Design, Setting, Participants Zilucoplan was tested as regimen A HEALEY ALS Platform Trial, phase 2 to 3 multicenter, randomized, double-blind, placebo-controlled perpetual platform clinical trial sharing...
Importance Treatment options for amyotrophic lateral sclerosis (ALS) remain suboptimal. Results from a phase 2 study of reldesemtiv in ALS suggested that it may slow disease progression. Objective To assess the effect vs placebo on functional outcomes ALS. Design, Setting, and Participants A Study to Evaluate Efficacy Safety Reldesemtiv Patients With Amyotrophic Lateral Sclerosis (COURAGE-ALS) was double-blind, placebo-controlled 3 randomized clinical trial conducted at 83 centers 16...
Pathological laughing and crying is a disorder of emotional expression seen in number neurological diseases. The aetiology poorly understood, but clinical descriptions suggest emotion regulation. goals this study were: (i) to characterize the subjective, behavioural physiological reactions that occur during episodes pathological crying; (ii) compare responses these those when emotions are elicited under standard conditions (watching sad amusing films, being startled); (iii) examine ability...
Objective: Behavioral variant frontotemporal dementia (bvFTD), is commonly considered the cognitive presentation of dementia-motor neuron disease (FTD-MND) spectrum disorder. We evaluated prevalence primary progressive aphasia in a series pathologically confirmed cases FTD-MND spectrum. Methods: Pathologically lobar degeneration-motor (FTLD-MND) were obtained from UCSF brain bank. Cases analyzed for presence language impairment via retrospective chart review research visits that include...
Abstract Introduction The Advancing Research and Treatment in Frontotemporal Lobar Degeneration Longitudinal Evaluation of Familial Dementia Subjects longitudinal studies were designed to describe the natural history familial‐frontotemporal lobar degeneration due autosomal dominant mutations. Methods We examined cognitive performance, behavioral ratings, brain volumes from first time point 320 MAPT , GRN C9orf72 family members, including 102 non–mutation carriers, 103 asymptomatic 43...
Background Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development disease-modifying agents may be facilitated relative clinical and pathological homogeneity SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) promising marker, therefore investigated utility...
<h3>Importance</h3> Individuals with tuberous sclerosis complex can develop a progressive neuropsychiatric syndrome known as sclerosis–associated disorders. Tuberous disorders symptoms overlap clinical criteria for frontotemporal dementia, yet the association between 2 has not been explored. <h3>Objective</h3> To investigate potential and dementia. <h3>Design, Setting, Participants</h3> Case-control study that enrolled patients normal IQs in an observational at University of California, San...
Abstract Tuberous sclerosis complex (TSC), a heritable neurodevelopmental disorder, is caused by mutations in the TSC1 or TSC2 genes. To date, there has been little work to elucidate regional and gene expression within human brain, how it changes with age, may influence disease. Using publicly available microarray dataset, we found that was highest adult neo-cerebellum this pattern of increased cerebellar maintained throughout postnatal development. During mid-gestational fetal development,...
Background The spectrum of motor neuron disease (MND) includes numerous phenotypes with various life expectancies. degree upper and lower involvement can impact prognosis. Phase sensitive inversion recovery (PSIR) imaging has been shown to detect in vivo gray matter (GM) white (WM) atrophy the spinal cord other patient populations but not explored MND. Methods In this study, total cord, WM GM areas ten patients a diagnosis within MND were compared those healthy controls (HC). Patients'...
Background Amyotrophic lateral sclerosis (ALS) is a rare disease with urgent need for improved treatment. Despite the acceleration of research in recent years, there to understand full natural history disease. As only 40% people living ALS are eligible typical clinical trials, trial datasets may not generalize population. While biomarker and cohort studies have more generous inclusion criteria, these too represent range phenotypes, particularly if burden participation high. To permit...
The interaction of CD40L and its receptor CD40 on activated T cells B respectively control pro-inflammatory activation in the pathophysiology autoimmunity transplant rejection. Previous studies have implicated signaling pathways involving (interchangeably referred to as CD154), well adaptive innate immune cell activation, induction neuroinflammation neurodegenerative diseases. This study aimed assess safety, tolerability, impact biomarker profiles an anti antibody, tegoprubart, individuals...
Abstract Background and Objectives Times to clinically relevant events are a valuable outcome in observational interventional studies, complementing linear outcomes such as functional rating scales biomarkers. In ALS, there several events. We developed dynamic prediction models for of these times that can be used clinical trial modeling personal planning. Methods Landmark time-to-event analysis was implemented determine the effect patient characteristics on disease progression. Longitudinal...
Background and objectives: Important landmarks in progression of ALS can occur prior to death. Predictive models for the time these assist clinical trial design personal patient planning. We propose a predictive model, using semi-competing risks modeling approach, five important disease ALS. Methods: Longitudinal data on 1,508 participants from Natural History Consortium were used, including ALSFRS-R score collected at different clinic visits baseline characteristics. A approach was used...
To determine whether spinal cord imaging using Phase sensitive inversion recovery (PSIR) is to motor neuron disease (MND).
Health systems are increasingly interested in collaborative dementia care. Implementation challenges include the limited specialist workforce, time pressures of high-volume care, increasing use telemedicine, and inadequate reimbursement. The Care Ecosystem is a telephone-based care model designed to augment existing healthcare services be amenable scale. Here we present latest evidence for Ecosystem, including effects among subpopulations at risk health disparities (rural Hispanic/Latino),...
To report percentage and general information on patients receiving edaravone in the clinics members of ALS Natural History Study Consortium.
Objective: To identify differences in neuropsychiatric symptoms between persons with autosomal dominant (ADAD) and late onset Alzheimer’s disease (LOAD). Background: It is important from both a diagnosis treatment perspective to common distinctive behavioral features of genetic subtypes (AD). The Neuropsychiatric Inventory (NPI) elicits informants’ report the presence these symptoms. Design/Methods: We studied ADAD LOAD patients Clinical Dementia Rating (CDR) scores 0.5-1 full-scale NPI...
OBJECTIVE: We defined cutoff values for 3-month changes in forced vital capacity-percent of predicted (FVC[percnt]) and motor unit number estimate (MUNE) that identify amyotrophic lateral sclerosis (ALS) patients with rapidly progressive disease,defined as survival 30 months or less from symptom onset. BACKGROUND: An independent measure lower neuron function can be monitored over time is essential to evaluating the effect treatments determining prognosis ALS. Longitudinal FVC[percnt] MUNE...