A5074840299- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Cancer survivorship and care
- Amyotrophic Lateral Sclerosis Research
- Family Support in Illness
- Neurological disorders and treatments
- Family and Disability Support Research
- Alzheimer's disease research and treatments
- Palliative Care and End-of-Life Issues
- Chemical synthesis and alkaloids
- Health disparities and outcomes
- Neurobiology of Language and Bilingualism
- Autism Spectrum Disorder Research
- RNA Interference and Gene Delivery
- Psychedelics and Drug Studies
- Testicular diseases and treatments
- Neurogenetic and Muscular Disorders Research
- Parasitic infections in humans and animals
- Effects of Radiation Exposure
- Neuroblastoma Research and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Healthcare professionals’ stress and burnout
- Takotsubo Cardiomyopathy and Associated Phenomena
- Olfactory and Sensory Function Studies
- Hereditary Neurological Disorders
University of California, San Francisco
2015-2025
San Francisco VA Medical Center
2020-2024
Centre for Movement Disorders
2024
San Francisco VA Health Care System
2022-2023
TU Dresden
2023
University of Wrocław
2023
Institute of Psychology
2023
Guyra Paraguay
2023
Geriatric Research Education and Clinical Center
2022
University of California San Francisco Medical Center
2022
<h3>Background and Objectives</h3> There is growing interest in health-related quality of life (HRQOL) as a comprehensive view the patient9s well-being, guiding concept for treating clinician, therapeutic trial outcome measure patients with Parkinson disease (PwPD). The key determinants HRQOL have not been investigated large populations PwPD. Our objective was to evaluate correlates large, online cohort <h3>Methods</h3> As part an ongoing study, we performed cross-sectional analysis at...
Importance Neurodegenerative disorders are now the most common reason that Medicare beneficiaries enroll in hospice for end-of-life care. People with all-cause dementia have high rates of suboptimal use, but little is known about use patterns Lewy body disease, which includes both Parkinson disease (PD) and bodies (DLB). Objective To compare patient characteristics, agency PD DLB vs Alzheimer (AD). Design, Setting, Participants A retrospective cohort study including a 100% sample national...
BACKGROUND As cancer survivorship increases, health care systems will be challenged to meet patient needs. With the limited availability of clinician time and resources, novel methods using patient‐reported outcomes may improve quality efficiency follow‐up in patients with breast cancer. METHODS The authors conducted a randomized trial TNM stage I III comparing standard SIS.NET (System for Individualized Survivorship Care, based on self‐reported data, review by Nurse practitioners, targeted...
Our objective was to evaluate the association between cognitive-behavioral deficits and patient quality of life (QoL), caregiver burden, disease stage in a population patients with amyotrophic lateral sclerosis (ALS). We administered ALS Cognitive-Behavioral Screen™ 86 ALS. Multiple regression used cognitive or behavioral stage, QoL, burden while controlling for clinically important variables. Of participants enrolled, 53 (62%) had some degree impairment, 32 (37%) were behaviorally impaired...
To evaluate the association between baseline apathy and probable incident dementia in a population-based sample of community-dwelling older adults.We studied 2,018 white black adults from Health, Aging, Body Composition (Health ABC) study. We measured at year 6 (our study baseline) with modified Apathy Evaluation Scale divided participants into tertiles based on low, moderate, or severe symptoms. Incident was ascertained over 9 years by medication use, hospital records, clinically relevant...
Anxiety and depression are common non-motor symptoms in Parkinson's disease (PD) but remain under-recognized under-treated.
Abstract Introduction The Advancing Research and Treatment in Frontotemporal Lobar Degeneration Longitudinal Evaluation of Familial Dementia Subjects longitudinal studies were designed to describe the natural history familial‐frontotemporal lobar degeneration due autosomal dominant mutations. Methods We examined cognitive performance, behavioral ratings, brain volumes from first time point 320 MAPT , GRN C9orf72 family members, including 102 non–mutation carriers, 103 asymptomatic 43...
To prospectively evaluate the progression of cognitive-behavioral function in amyotrophic lateral sclerosis (ALS) and examine association deficits with disease progression, patient quality life (QOL), caregiver burden.We evaluated using Amyotrophic Lateral Sclerosis Cognitive Behavioral Screen at enrollment after 7 months a cohort patients ALS. Paired t tests were used to change 2 assessments. Linear regression Kruskal-Wallis applied investigate how initial cognitive or behavioral status...
Background: Palliative care has the potential to address significant unmet needs in people with Parkinson’s disease and related disorders, but models that rely on in-person specialty palliative teams have limited scalability. Aim: To describe patient partner experiences a novel, community-based intervention for disease. Design: Qualitative study embedded randomized clinical trial document participant novel (community neurologist training remote team-based specialist care). Transcripts were...
<h3>Background and Objectives</h3> There is increasing interest in characterizing the earliest phases of Parkinson disease (PD). However, few studies have investigated prediagnostic trajectories cognition function. Our objective was to describe cognitive functional PD older women men. <h3>Methods</h3> We studied 9,595 5,795 men from 2 prospective cohort community-dwelling elders followed up 20 years. In individuals without prevalent PD, we estimated associations incident diagnosis with rates...
Health care delivery systems transformed rapidly at the beginning of coronavirus disease 2019 (COVID-19) pandemic to slow spread virus while identifying novel methods for providing care. In many ways, affected both persons with neurologic illness and neurologists. This study describes perspectives experiences community neurologists patients neurodegenerative illnesses during COVID-19 pandemic.
Intranasal insulin (IN) administration is a promising way to deliver the peptide central nervous system (CNS), bypassing blood-brain-barrier and gastrointestinal absorption inhibition. IN receptors are localized in olfactory mucosa brain, mainly bulb, hypothalamus, hippocampus, amygdala, cerebral cortex, cerebellum. The pleiotropic mechanism of action characterized by its anti-inflammatory properties, antithrombotic, vasodilatory, antiapoptotic effects. It prevents energy failure has...
Importance Life space is a measure of the frequency, range, and independence movement through environment. There increasing interest in life as holistic function older adults, but association between change incident neurodegenerative disease unknown. Objective To evaluate cognitive decline or over 7 years among community-dwelling men. Design, Setting, Participants In this cohort study, logistic regression analyses were used to examine baseline with cognition unadjusted adjusted for...
To investigate the value of knowledgeable informant reports in early stage Parkinson's disease (PD)