A5101511252- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Neurological diseases and metabolism
- Radar Systems and Signal Processing
- Statistical Methods and Inference
- Millimeter-Wave Propagation and Modeling
- Microwave Engineering and Waveguides
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Advanced MIMO Systems Optimization
- Dynamics and Control of Mechanical Systems
- Pharmacological Receptor Mechanisms and Effects
- DNA and Biological Computing
- Prostate Cancer Diagnosis and Treatment
- Antenna Design and Optimization
- Neuroinflammation and Neurodegeneration Mechanisms
- Prion Diseases and Protein Misfolding
- Prostate Cancer Treatment and Research
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
WinnMed
2021-2025
Mayo Clinic in Florida
2020-2025
Jacksonville College
2021-2025
University of Minnesota
2023-2025
Neurology, Inc
2020
Importance The etiology of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, is unknown. However, neuroinflammation and complement activation may play role in disease progression. Objective To determine the effects zilucoplan, an inhibitor C5, individuals with ALS. Design, Setting, Participants Zilucoplan was tested as regimen A HEALEY ALS Platform Trial, phase 2 to 3 multicenter, randomized, double-blind, placebo-controlled perpetual platform clinical trial sharing...
Abstract Background A repeat expansion in the C9orf72-SMCR8 complex subunit ( C9orf72 ) is most common genetic cause of two debilitating neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Currently, much remains unknown about which variables may modify these diseases. We sought to investigate associations between promoter methylation, RNA expression levels, length, their potential effects on disease features, as well changes over time within...
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two devastating fatal neurodegenerative conditions. While distinct, they share many clinical, genetic, pathological characteristics 1 , both show selective vulnerability of layer 5b extratelencephalic-projecting cortical populations, including Betz cells in ALS 2,3 von Economo neurons (VENs) FTLD 4,5 . Here, we report the first high resolution single-cell atlas human primary motor cortex (MCX) its...
This work establishes regularity conditions for consistency and asymptotic normality of the multiple parameter maximum likelihood estimator(MLE) from censored data, where censoring mechanism is in form $1$-bit measurements. The underlying distribution uncensored data assumed to belong exponential family, with natural parameters expressed as a linear combination predictors, known generalized model (GLM). As part analysis, Fisher information matrix also derived both which helps quantify impact...
Abstract Background The gene C9orf72 harbors a non-coding hexanucleotide repeat expansion known to cause amyotrophic lateral sclerosis and frontotemporal dementia. While previous studies have estimated the length of this in multiple tissues, technological limitations impeded researchers from exploring additional features, such as methylation levels. Methods We aimed characterize expansions using targeted, amplification-free long-read sequencing method. Our primary goal was determine presence...
Cortical hyperexcitability is a feature of amyotrophic lateral sclerosis (ALS) and cortical excitability can be measured using transcranial magnetic stimulation (TMS). Resting motor threshold (MT) measure excitability, largely driven by glutamate. Perampanel, glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor blocker, predicted to increase the threshold. This study aimed evaluate TMS functionally assess target engagement in perampanel ALS.We studied MT ALS...
AbstractIntroduction/Aims. Primary lateral sclerosis (PLS) is exceedingly rare and has been an enigmatic disease. Recent progress drastically changed this perception, with early biomarkers being investigated potential medications for PLS emerging at the preclinical stage. The aim of paper to describe a study natural history discuss limitations proposed solutions slowly progressive Methods. Natural History Study 30-site, 24-month, prospective that supported by multiple funding sources. aims...
Millimeter-wave (mmWave) spectrum is expected to support data-intensive applications that require ultra-reliable low-latency communications (URLLC). However, mmWave links are highly sensitive blockage, which may lead disruptions in the communication. Traditional techniques build resilience against such blockages (among interleaving and feedback mechanisms) incur delays too large effectively URLLC. This calls for novel ensure resilient In this paper, we propose deploy multilevel codes over...
Objective: To study the association between ventilatory function and cognitive behavioral impairment in ALS patients accounting for effects of pertinent covariates. Methods: Four hundred eighty-one were identified from Mayo Clinic Florida registry who had concurrent forced vital capacity (FVC) testing using Cognitive Behavioral Screen (ALS-CBS). Multiple linear regression analysis was used to FVC relevant covariates on ALS-CBS cognition score, subscores, caregiver inventory. Results:...
Abstract Introduction/aims Muscle cramps are a common and often disabling symptom in amyotrophic lateral sclerosis (ALS), devastating incurable neurodegenerative disorder. To date, there no medications specifically approved for the treatment of muscle cramps. Ameliorating ALS may improve sustain quality life. A widely prescribed traditional Japanese (Kampo) medicine against cramps, shakuyakukanzoto (TJ-68), has been studied advanced liver disease, spinal stenosis, kidney failure, diabetic...
Abstract Introduction/Aims: Muscle cramps are a common and often disabling symptom in Amyotrophic Lateral Sclerosis (ALS), devastating incurable neurodegenerative disorder. To date, there no medications specifically approved for the treatment of muscle cramps. Ameliorating this patient population may sustain quality life longer. A traditional Japanese medicine, shakuyakukanzoto (TJ-68) is widely prescribed Japan managing variety conditions. The ALS Management Guideline mentions TJ-68...
This work considers a co-located MIMO radar with M <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> transmitting and xmlns:xlink="http://www.w3.org/1999/xlink">R</inf> receiving antennas in so-called massive regime, that is, where the number of virtual spatial N = is large. Recently, it has been demonstrated as grows to infinity, one can fully characterize false alarm detection probabilities very minimal assumptions on disturbance vector....
You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy I1 Apr 2017PD10-07 RELIABILITY OF PROSTATE HISTOSCANNING IN THE LOCALIZATION AND VOLUME ESTIMATION CARCINOMA Abhishek Singh, Ankush Jairath, Jaimin Shah, Arvind Ganpule, Ravindra Sabnis, and Mahesh Desai SinghAbhishek Singh More articles by this author , JairathAnkush Jairath ShahJaimin Shah GanpuleArvind Ganpule SabnisRavindra Sabnis DesaiMahesh View All Author...
Introduction: Nusinersen antisense oligonucleotide infusions have been shown to be effective in the treatment spinal muscular atrophy. The majority of evidence has collected young type 1 and 2 patients, efficacy adult patients is limited. Case Report: A 48-year-old woman with atrophy 3 who received loading dose 8 maintenance over an 8-month period. Grip pinch strength, measured by hand-held dynamometry at baseline 6 12 months interval improved a 24-month She also reported multiple other...
Tuesday, April 28April 14, 2020Free AccessMultivariate Analysis of Survival in an Amyotrophic Lateral Sclerosis Clinic Population (5268)Jaimin Shah, Marka Van Blitterswijk, Rosa Rademakers, Otto Pedraza, Beth Rush, Jany Paulett, Janay Caradonna, Leonard Petrucelli, and Bjorn OskarssonAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.5268 Letters to the Editor