A5103107303- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Genomics and Rare Diseases
- Trace Elements in Health
- Parkinson's Disease Mechanisms and Treatments
- Amino Acid Enzymes and Metabolism
- Spinal Fractures and Fixation Techniques
- Arsenic contamination and mitigation
- Family and Disability Support Research
- Heavy Metal Exposure and Toxicity
- Spinal Hematomas and Complications
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Glycogen Storage Diseases and Myoclonus
- Infectious Diseases and Tuberculosis
- Neuroscience and Neural Engineering
- Myasthenia Gravis and Thymoma
- Alzheimer's disease research and treatments
- Neurosurgical Procedures and Complications
- Prion Diseases and Protein Misfolding
- Cervical and Thoracic Myelopathy
- Inflammatory Myopathies and Dermatomyositis
- Metalloenzymes and iron-sulfur proteins
Medical College of Wisconsin
2015-2025
University of Wisconsin–Milwaukee
2020
UW Health University Hospital
2002-2003
Importance The etiology of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, is unknown. However, neuroinflammation and complement activation may play role in disease progression. Objective To determine the effects zilucoplan, an inhibitor C5, individuals with ALS. Design, Setting, Participants Zilucoplan was tested as regimen A HEALEY ALS Platform Trial, phase 2 to 3 multicenter, randomized, double-blind, placebo-controlled perpetual platform clinical trial sharing...
<h3>Objective</h3> An estimated 1.4 million young caregivers (<19 years of age) in the United States provide care to ill family members yet remain hidden from state and national caregiving programs services, including amyotrophic lateral sclerosis (ALS) services. Given intensive needs acuity ALS, appreciation caregiver experience within context may have a significant impact on patient quality life. This article seeks identify youth characteristics perceptions through interviews with 38...
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder characterized by the loss of upper and lower motor neurons. Approximately 10% cases are caused specific mutations in known genes, with remaining having no genetic link. As such, sporadic have been more difficult to model experimentally. Here, we describe generation differentiation ALS induced pluripotent stem cells reprogrammed from discordant identical twins. Whole genome sequencing revealed relevant ALS-causing...
Aim: Pilot study of a novel caregiving training and support intervention for children youth <19 years, who provide care person living with amyotrophic lateral sclerosis. Materials & methods: Youth (n = 19) between the ages 8-19 participated in skills program (basic care, feeding/communication, assistive devices social support). Results: Participants reported significant increase confidence tasks, including communication systems respiratory equipment. identified goal setting creating...
Objective: To report the results of 7 years our collaboration program. Background: In Ecuador-Amazon region, it is estimated that over 70[percnt] patients with epilepsy do not receive appropriate treatment due to lack access neurological diagnosis and care. The city Tena, located in Napo-Province rural Amazon region Ecuador, 200 kilometers away from nearest facility services. We introduced an clinic this created a system locally sustain it. Design/Methods: organized annual clinics local...