A5080276406- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Dysphagia Assessment and Management
- Parkinson's Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Herpesvirus Infections and Treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Insect and Pesticide Research
- Child Nutrition and Feeding Issues
- Cholinesterase and Neurodegenerative Diseases
- Tracheal and airway disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Virus-based gene therapy research
- Neurological diseases and metabolism
- Advancements in Transdermal Drug Delivery
- Toxoplasma gondii Research Studies
- Neurobiology and Insect Physiology Research
- Protist diversity and phylogeny
- Neurological disorders and treatments
- Biochemical Acid Research Studies
- Pharmacological Receptor Mechanisms and Effects
- Nerve injury and regeneration
- Dialysis and Renal Disease Management
- Prion Diseases and Protein Misfolding
University of Florida
2017-2025
Florida College
2017-2024
Google (United States)
2022-2023
Nova Southeastern University
2023
University of South Florida
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2022
Newcastle University
2022
Sodium phenylbutyrate and taurursodiol have been found to reduce neuronal death in experimental models. The efficacy safety of a combination the two compounds persons with amyotrophic lateral sclerosis (ALS) are not known.
Abstract An orally administered, fixed‐dose coformulation of sodium phenylbutyrate‐taurursodiol (PB‐TURSO) significantly slowed functional decline in a randomized, placebo‐controlled, phase 2 trial ALS (CENTAUR). Herein we report results long‐term survival analysis participants CENTAUR. In CENTAUR, adults with were randomized 2:1 to PB‐TURSO or placebo. Participants completing the 6‐month (24‐week) eligible receive open‐label extension. all‐cause mortality (35‐month maximum follow‐up...
Keratinocytes are implicated in sensory transduction and can influence nociception, but whether these contribute to chronic pain is not known. In neurons, voltage-gated sodium channels (Na(v)) involved neuropathic activated by depolarization. Since keratinocytes also show changes membrane potential, we used RT-PCR, situ hybridization, immunohistochemistry investigate the expression of cells. Na(v)1.1, Na(v)1.6, Na(v)1.8 were localized within rat epidermis. addition, release ATP from response...
Abstract Objective To evaluate the efficacy and safety of DM/Q (capsules containing dextromethorphan [DM] quinidine [Q]) compared with placebo, taken twice daily, for treatment pseudobulbar affect over a 12‐week period in multiple sclerosis patients. Methods A total 150 patients were randomized double‐blind, placebo‐controlled study to assess validated Center Neurologic Study‐Lability Scale. Each patient also recorded number episodes experienced between visits, estimated quality life...
The aims of this multicenter, randomized, placebo-controlled, double-blind trial were to confirm the efficacy lacosamide at a daily dose 400 mg/d and explore efficacy, safety, tolerability 200 600 in treatment painful diabetic neuropathy.The consisted 2-week run-in period, 6-week titration phase, 12-week maintenance during which patients received placebo or fixed doses 200, 400, mg/d. No back was allowed trial. primary criterion change Likert pain score from baseline average over last 4...
Summary In a variety of chronic pain conditions, calcitonin gene-related peptide (CGRP) is expressed at high levels in the skin, blood, and cerebrospinal fluid. Our results reveal that much increase may be due to CGRPβ isoform made by epidermal keratinocytes, which express CGRP immunoreactivity human animal conditions. Calcitonin vasodilatory has been detected fluid (CSF) under inflammatory presumably derived from peptidergic C Aδ innervation. Herein, immunolabeling (IL) was keratinocytes...
ObjectiveTo determine if peripheral neuropathology exists among the innervation of cutaneous arterioles and arteriole–venule shunts (AVS) in fibromyalgia (FM) patients.
The goal of this randomized, blinded, crossover clinical trial was to determine whether Nuedexta (dextromethorphan and quinidine) enhanced speech, swallowing, salivation in patients with ALS. Sixty amyotrophic lateral sclerosis (ALS) received either or placebo for 28 30 days, followed by a 10 15-day washout period. Subsequently, were switched the opposite treatment arm remaining days trial. primary endpoint reduction self-report Center Neurologic Study Bulbar Function Scale (CNS-BFS) score....
Coformulated sodium phenylbutyrate/taurursodiol (PB/TURSO) was shown to prolong survival and slow functional decline in amyotrophic lateral sclerosis (ALS).
<h3>Importance</h3> Understanding the natural history of familial amyotrophic lateral sclerosis (ALS) caused by <i>SOD1</i> mutations (ALS<sup>SOD1</sup>) will provide key information for optimising clinical trials in this patient population. <h3>Objective</h3> To establish an updated ALS<sup>SOD1</sup>. <h3>Design, setting and participants</h3> Retrospective cohort study from 15 medical centres North America evaluated records 175 patients with ALS genetically confirmed mutations, cared...
The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcriptomes individual human DRG (hDRG) neurons-critical in-formation to decipher their functions-are lacking due technical difficulties. Here, we developed a novel approach isolate hDRG neuron somas for deep RNA sequencing (RNA-seq). On average, >9,000 unique genes per were detected, and 16 neuronal types identified. Cross-species analyses revealed remarkable divergence among...
Abstract The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcriptomes individual human (h)DRG neurons—critical information to decipher their functions—are lacking due technical difficulties. In this study, we isolated somata hDRG neurons and conducted deep RNA sequencing (RNA-seq) detect, on average, over 9,000 unique genes per neuron, identified 16 neuronal types. These results were corroborated validated by spatial...
The large subunit of the herpes simplex virus type 2 (HSV-2) ribonucleotide reductase (RR1) is demonstrated to possess serine/threonine-specific kinase activity. Computer-assisted sequence analysis identified regions within amino terminus ICP10 that are homologous catalytic domain known protein kinases (PKs). An in vitro assay confirmed ability ICP10, immunoprecipitated from either HSV-2-infected cells or transfected with an expression vector, autophosphorylate and transphosphorylate...
Objective: Speech and swallowing impairments are highly prevalent in individuals with amyotrophic lateral sclerosis (ALS) contribute to reduced quality of life, malnutrition, aspiration, pneumonia death. Established practice parameters for bulbar dysfunction ALS do not currently exist. The aim this study was identify current patterns the evaluation speech function within participating Northeast clinics United States. Methods results: A 15-item survey emailed all registered NEALS centres....
Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set provisional ALS guidelines, available for immediate implementation within all clinics.ALS specialists across multiple related disciplines participated series symposia, intending identify and summarize the accepted practices assessment management dysfunction...
Objective To evaluate safety, dose response, and preliminary efficacy of reldesemtiv over 12 weeks in patients with amyotrophic lateral sclerosis (ALS). Methods: Patients (≤2 years since diagnosis) slow upright vital capacity (SVC) ≥60% were randomized 1:1:1:1 to 150, 300, or 450 mg twice daily (bid) placebo; active treatment was 4-week follow-up. Primary endpoint change percent predicted SVC at weeks; secondary measures included ALS Functional Rating Scale-Revised (ALSFRS-R) muscle strength...
<h3>Background and Objective</h3> The objective of this study was to evaluate the short-term physiologic effect one-year functional a 12-week inspiratory expiratory respiratory strength training (RST) program in individuals with amyotrophic lateral sclerosis (ALS). <h3>Methods</h3> A double-blinded, randomized, sham-controlled trial conducted 45 early-stage ALS. Participants were randomized into 12 weeks active RST (30% load, n = 23) or sham (0% 22). An intent-to-treat analysis conducted....
Importance The etiology of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, is unknown. However, neuroinflammation and complement activation may play role in disease progression. Objective To determine the effects zilucoplan, an inhibitor C5, individuals with ALS. Design, Setting, Participants Zilucoplan was tested as regimen A HEALEY ALS Platform Trial, phase 2 to 3 multicenter, randomized, double-blind, placebo-controlled perpetual platform clinical trial sharing...
Regulation of the expression herpes simplex virus (HSV) type 2 large subunit ribonucleotide reductase (ICP10) gene was studied directly by immunofluorescence or chloramphenicol acetyltransferase analysis with hybrid ICP10 promoter constructions. In Vero cells, cotransfection DNA encoding HSV IE110 Vmw65 proteins HCMV IE2 enhanced at least 10-fold. contrast, minimally IE175 low doses and slightly reduced high doses. IE110-mediated trans-activation minimal in primary astrocytes cells from line...
<h3>Importance</h3> Cryptogenic sensory polyneuropathy (CSPN) is a common generalized slowly progressive neuropathy, second in prevalence only to diabetic neuropathy. Most patients with CSPN have significant pain. Many medications been tried for pain reduction CSPN, including antiepileptics, antidepressants, and sodium channel blockers. There are no comparative studies that identify the most effective medication CSPN. <h3>Objective</h3> To determine which (pregabalin, duloxetine,...