A5024206518- Pancreatic and Hepatic Oncology Research
- Alzheimer's disease research and treatments
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Cancer Risks and Factors
- Advanced Neuroimaging Techniques and Applications
- Head and Neck Cancer Studies
- Cancer survivorship and care
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Dementia and Cognitive Impairment Research
- Statistical Methods in Clinical Trials
- Nutrition and Health in Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Pelvic floor disorders treatments
- Lung Cancer Diagnosis and Treatment
- Statistical Methods and Bayesian Inference
- Neurological Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Transplantation: Methods and Outcomes
- Glioma Diagnosis and Treatment
Washington University in St. Louis
2016-2025
Hohai University
2025
Mallinckrodt (United States)
2022-2024
Inner Mongolia Medical University
2024
Shanghai University of Traditional Chinese Medicine
2023-2024
Chongqing University
2024
Inner Mongolia University of Science and Technology
2020-2023
China Three Gorges University
2014-2023
China Aerospace Science and Industry Corporation (China)
2023
Barnes-Jewish Hospital
2016-2022
Preoperative skin antisepsis has the potential to decrease risk of surgical-site infection. However, evidence is limited guide choice antiseptic agent at cesarean delivery, which most common major surgical procedure among women in United States.
Obesity increases risk for all-cause and breast cancer mortality comorbidities in women who have been diagnosed treated cancer. The Exercise Nutrition to Enhance Recovery Good Health You (ENERGY) study is the largest weight loss intervention trial among survivors of date.In this multicenter trial, 692 overweight/obese were, on average, 2 years since primary treatment early-stage were randomly assigned either a group-based behavioral intervention, supplemented with telephone counseling...
Background Clinicopathological studies suggest that Alzheimer's disease (AD) pathology begins ∼10–15 years before the resulting cognitive impairment draws medical attention. Biomarkers can detect AD in its early stages and predict dementia onset would, therefore, be invaluable for patient care efficient clinical trial design. We utilized a targeted proteomics approach to discover novel cerebrospinal fluid (CSF) biomarkers augment diagnostic prognostic accuracy of current leading CSF (Aβ42,...
Targeting the desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) holds promise to augment effect chemotherapy, but success in clinic has thus far been limited. Preclinical mouse models suggest that near-depletion cancer-associated fibroblasts (CAF) carries a risk accelerating PDAC progression, underscoring need concurrently target key signaling mechanisms drive malignant attributes both CAF and cells. We previously reported inhibition IL1 receptor-associated kinase 4 (IRAK4)...
Summary Background and objectives To reduce racial disparities in transplant, modifiable patient characteristics associated with completion of transplant evaluation receipt living donor kidney must be identified. Design, setting, participants, & measurements From 2004 to 2007, 695 black white patients were surveyed about 15 less-modifiable 10 more-modifiable at onset; whether they had completed within 1 year received transplants by 2010 was determined. Logistic regression competing risks...
Pre-exposure prophylaxis (PrEP) can reduce U.S. HIV incidence. We assessed insurance coverage and its association with PrEP utilization. reviewed patient data at three clinics (Jackson, Mississippi; St. Louis, Missouri; Providence, Rhode Island) from 2014–2015. The outcome, utilization, was defined as use months. Multivariable logistic regression performed to determine the between Of 201 patients (Jackson: 34%; Louis: 28%; Providence: 28%), 91% were male, 51% White, median age 29 years, 21%...
<h3>Importance</h3> It is unclear whether the timing of second stage pushing efforts affects spontaneous vaginal delivery rates and reduces morbidities. <h3>Objective</h3> To evaluate immediate or delayed results in higher lower maternal neonatal <h3>Design, Setting, Participants</h3> Pragmatic randomized clinical trial nulliparous women at beyond 37 weeks' gestation admitted for induced labor with neuraxial analgesia between May 2014 December 2017 6 US medical centers. The interim analysis...
Alzheimer disease (AD) is primarily associated with accumulations of amyloid plaques and tau tangles in gray matter, however, it now acknowledged that neuroinflammation, particularly white matter (WM), significantly contributes to the development progression AD. This study aims investigate WM neuroinflammation continuum AD its association pathologies cognition using diffusion-based imaging (NII).
Cytomegalovirus (CMV) reactivation after allogeneic hematopoietic cell transplant (allo-HCT) has been associated with a reduced risk of relapse in patients acute myeloid leukemia (AML). However, the influence conditioning regimen on this protective effect CMV allo-HCT is relatively unexplored. To address this, we evaluated 264 AML who received T cell-replete, 6/6 HLA matched sibling or 10/10 unrelated donor transplantation at single institution between 2006 and 2011. Of these patients, 206...
Obesity increases the risk of death from many malignancies, including non-Hodgkin's lymphoma (NHL). In diffuse large B-cell (DLBCL), most common form NHL, association between body mass index (BMI) at diagnosis and survival is unclear.We evaluated BMI overall in a retrospective cohort 2,534 United States veterans diagnosed with DLBCL October 1, 1998 December 31, 2008. Cox modeling was used to control for patient- disease-related prognostic variables.Mean age 68 years (range, 20 100 years);...
<h3>Importance</h3> Understanding the natural history of familial amyotrophic lateral sclerosis (ALS) caused by <i>SOD1</i> mutations (ALS<sup>SOD1</sup>) will provide key information for optimising clinical trials in this patient population. <h3>Objective</h3> To establish an updated ALS<sup>SOD1</sup>. <h3>Design, setting and participants</h3> Retrospective cohort study from 15 medical centres North America evaluated records 175 patients with ALS genetically confirmed mutations, cared...
Our goal was to determine the optimal timing for repair of bile duct injuries sustained during cholecystectomy.Bile injury cholecystectomy is a serious complication that often requires surgical repair. There heterogeneity in literature regarding repair, and it remains unclear what extent determines postoperative morbidity long-term anastomotic function.A single institution prospective database queried all E1 E4 from 1989 2014 using standardized tabular reporting format. Timing stratified...
Despite early detection programs, many patients with prostate cancer present intermediate- or high-risk disease. We prospectively investigated whether <sup>11</sup>C-acetate PET/CT predicts lymph node (LN) metastasis and treatment failure in men for whom radical prostatectomy is planned. <b>Methods:</b> 107 localized negative conventional imaging findings underwent <sup>11</sup>C-acetate. Five LN staging only, 102 prostatectomy. were correlated pathologic nodal status. Treatment-failure–free...
To determine whether an MRI-based Alzheimer disease (AD) signature biomarker can detect tau-related neurodegeneration in preclinical AD, and to assess AD cortical thinning is associated with cognitive changes cognitively normal (CN) older individuals.In a large cohort of CN individuals (n = 188), we measured the hippocampal volume thickness within independently defined regions. We cross-sectionally assessed associations between or atrophy CSF biomarkers tau (increased tau) β-amyloid (Aβ)...
<h3>Importance</h3> Obesity increases the risk of both cesarean delivery and surgical-site infection. Despite widespread use, it is unclear whether prophylactic negative pressure wound therapy reduces infection after in obese women. <h3>Objective</h3> To evaluate therapy, initiated immediately delivery, lowers infections compared with standard dressing <h3>Design, Setting, Participants</h3> Multicenter randomized trial conducted from February 8, 2017, through November 13, 2019, at 4 academic...
Purpose The objective of this study is to identify how predisposing characteristics, enabling factors, and health needs are jointly individually associated with epidemiological patterns outpatient healthcare utilization for patients who already interact engage a large system. Methods We retrospectively analyzed electronic medical record data from 1,423,166 clinic visits 474,674 in system June 2018-March 2019. evaluated exclusively visited rural clinics versus urban using Chi-square tests the...
Abstract Background Prolonged ( &gt; 24 hours) post operative antibiotic (abx) use is the most common reason for inappropriate abx in hospitalized children occurring 40% of cases. Effective strategies are needed to reduce use. One strategy, facilitation, helps people develop skills change structure and processes within a system gap between evidence practice. This study evaluated best order set vs + deimplement unnecessary abxs.Figure 1:Operatic Stepped-Wedge Trial Design Stepped-wedge...
Abstract Objectives/Hypothesis: To perform a longitudinal description of swallowing function following transoral laser microsurgery (TLM) ± adjuvant therapy for advanced‐stage oropharyngeal cancer (OPC) and identify prognostic factors associated with performance. Study Design: Retrospective analysis descriptive study outcomes. Methods: Patients treated TLM AJCC stage III–IV OPC at Washington University from 1996 to 2008 were included. A search medical records direct patient contact performed...