A5006212733- Dementia and Cognitive Impairment Research
- Protease and Inhibitor Mechanisms
- HER2/EGFR in Cancer Research
- Cell death mechanisms and regulation
- Alzheimer's disease research and treatments
- Radiation Effects in Electronics
- Cellular transport and secretion
- Estrogen and related hormone effects
- Computational Drug Discovery Methods
- Semiconductor materials and devices
- Hydrocarbon exploration and reservoir analysis
- VLSI and Analog Circuit Testing
- Low-power high-performance VLSI design
- Advanced Neural Network Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Model Reduction and Neural Networks
- Advanced Neuroimaging Techniques and Applications
- Integrated Circuits and Semiconductor Failure Analysis
- Probabilistic and Robust Engineering Design
- DNA and Nucleic Acid Chemistry
- Advanced Memory and Neural Computing
- Advanced Image Processing Techniques
- Advanced Vision and Imaging
- Geological and Geophysical Studies
- VLSI and FPGA Design Techniques
Fudan University
2014-2025
State Key Laboratory of ASIC and System
2010-2025
Shanghai Fudan Microelectronics (China)
2008-2024
Washington University in St. Louis
2015-2024
Mallinckrodt (United States)
2020-2024
China University of Petroleum, Beijing
2024
Southwest Petroleum University
2008-2023
PetroChina Southwest Oil and Gas Field Company (China)
2008-2023
Prevent Alzheimer’s Disease 2020
2022-2023
Northwestern University
2007-2023
There are abundant marine shale gas resources in the Sichuan Basin. After almost one decade of exploration and development, three national demonstration areas have been built Basin its periphery, large-scale commercial development middle deep (above 3500 m depth) has successfully achieved. The volume (3500–4500 deep) upper Ordovician Wufeng Formation-lower Silurian Longmaxi Formation southern is 6.6 × 1012 m3, with huge exploitation potential, so it an important area for production increase...
Abstract Amyloid PET imaging has been crucial for detecting the accumulation of amyloid beta (Aβ) deposits in brain and to study Alzheimer’s disease (AD). We performed a genome-wide association on largest collection data (N = 13,409) date, across multiple ethnicities from multicenter cohorts identify variants associated with amyloidosis AD risk. found strong APOE signal chr19q.13.32 (top SNP: ɛ4; rs429358; β 0.35, SE 0.01, P 6.2 × 10 –311 , MAF 0.19), driven by ɛ4, five additional novel...
Alzheimer disease (AD) is primarily associated with accumulations of amyloid plaques and tau tangles in gray matter, however, it now acknowledged that neuroinflammation, particularly white matter (WM), significantly contributes to the development progression AD. This study aims investigate WM neuroinflammation continuum AD its association pathologies cognition using diffusion-based imaging (NII).
Podosomes mediate cell migration and invasion by coordinating the reorganization of actin cytoskeleton focal matrix degradation. MMP serine proteases have been found to function at podosomes. The lysosomal cysteine cathepsins, a third major class matrix-degrading enzymes involved in tumor tissue remodeling, yet be linked podosomes with exception cathepsin K osteoclasts. Using inhibitors shRNA-mediated depletion, we show that B participates podosomes-mediated degradation v-Src-transformed...
To speedup Deep Neural Networks (DNN) accelerator design and enable effective implementation, we propose HybridDNN, a framework for building high-performance hybrid DNN accelerators delivering FPGA-based hardware implementations. Novel techniques include highly flexible scalable architecture with Spatial/Winograd convolution (CONV) Processing Engine (PE), comprehensive space exploration tool, complete flow to fully support implementation. Experimental results show that the generated by...
Abstract Epidermal growth factor receptor (EGFR), a member of the ErbB family tyrosine kinases, is overexpressed in as many 60% cases breast and other cancers. EGFR overexpression characteristic highly aggressive molecular subtypes cancer with basal-like BRCA1 mutant phenotypes distinct from ErbB2-overexpressing Yet, substantially weaker compared ErbB2 promoting oncogenic transformation nontumorigenic human mammary epithelial cells (human MEC), suggesting role for cooperating oncogenes....
Machine learning based methods for blind deblurring are efficient to handle real-world blurred images, whose blur may be caused by various combined distortions. However, existing multi-level architectures fail fit images of scenarios. In this paper, we propose a scale-iterative upscaling network (SIUN) that restores sharp in an iterative manner. It is not only able preserve the advantages weights sharing across scales but also more flexible when training and predicting with different...
This study aims to quantify microglial activation in individuals with Alzheimer disease (AD) using the 18-kDa translocator protein (TSPO) PET imaging hippocampus and precuneus, 2 AD-vulnerable regions, evaluate association of baseline neuroinflammation amyloidosis, tau, longitudinal cognitive decline.Twenty-four participants from Knight Disease Research Center (Knight ADRC) were enrolled classified into stable cognitively normal, progressor, symptomatic AD groups based on clinical dementia...
Abstract Wide‐bandgap (WBG) semiconductors are at the forefront of driving innovations in electronic technology, perpetuating Moore's Law and opening up new avenues for devices. Although β ‐Ga 2 O 3 has attracted extensive research interest advanced electronics, its high‐temperature high‐speed volatile memory applications harsh environment been largely overlooked. Herein, a high‐performance hexagonal boron nitride (h‐BN)/ heterostructure junction field‐effect transistor (HJFET) is...
The E3 ubiquitin ligase Casitas B lymphoma protein (Cbl) controls the ubiquitin-dependent degradation of EGF receptor (EGFR), but its role in regulating downstream signaling elements with which it associates and impact on biological outcomes EGFR are less clear. Here, we demonstrate that stimulation human mammary epithelial cells disrupts adherens junctions (AJs) through Vav2 Rac1/Cdc42 activation. In EGF-stimulated cells, Cbl regulates levels phosphorylated thereby attenuating activity....
<h3>Objective</h3> To investigate the inherent clinical risks associated with presence of cerebral microhemorrhages (CMHs) or microbleeds and characterize individuals at high risk for developing hemorrhagic amyloid-related imaging abnormality (ARIA-H), we longitudinally evaluated families dominantly inherited Alzheimer disease (DIAD). <h3>Methods</h3> Mutation carriers (n = 310) noncarriers 201) underwent neuroimaging, including gradient echo MRI sequences to detect CMHs, neuropsychological...
Amyloidosis, including cerebral amyloid angiopathy, and markers of small vessel disease (SVD) vary across dominantly inherited Alzheimer's (DIAD) presenilin-1 (PSEN1) mutation carriers. We investigated how position relative to codon 200 (pre-/postcodon 200) influences these pathologic features dementia at different stages. Individuals from families with known PSEN1 mutations (n = 393) underwent neuroimaging clinical assessments. cross-sectionally evaluated regional Pittsburgh compound...
Antiretroviral agents may participate in drug interactions that influence the efficacy and toxicity of other antiretrovirals, as well pharmacologic treatments coincident or complicating diseases. The viral protease inhibitor, ritonavir, cause by inhibiting activity cytochrome P450‐3A (CYP3A) isoforms. In a single‐dose, blinded, four‐way crossover study, 10 healthy volunteer subjects received 50 mg trazodone hydrochloride matching placebo concurrent with low‐dose ritonavir (four doses 200...
Major discoveries of natural gas have recently been made in the oolitic dolostones Early Triassic Feixianguan Formation NE Sichuan Province, Southern China. These were formed by three facies‐controlled dolomitization processes: (i) meteoric mixing zone with dolomites having a relatively high degree crystalline order (δ 13 C:−1.0 to 2.5% PDB ; δ 18 O:−6.5 −2.5% ); (ii) seepage‐reflux associated evaporative brines; corresponding dolomite crystals are ordered and tidal flat environments...
Convolutional neural networks (CNNs) are widely used in machine learning applications. Large scale, most deep CNNs however difficult to be implemented on a single hardware for acceleration. This paper presents new design and implementation of 23-layer SqueezeNet [1] Xilinx VC709 FPGA board. In this design, novel layer-based structured method is proposed full scalability constructing CNNs, which all the CNN layers optimized deployed separately independently. Moreover, inherent parallelism...
Ubiquitin conjugation to receptor tyrosine kinases is a critical biochemical step in attenuating their signaling through lysosomal degradation. Our previous studies have established Cbl as an E3 ubiquitin ligase for ubiquitinylation and degradation of platelet-derived growth factor (PDGFR) alpha PDGFRbeta. However, the role endogenous PDGFR regulation molecular mechanisms this remain unclear. Here, we demonstrate that essential ligand-induced PDGFRbeta; involves TKB domain binding PDGFRbeta...
Memory circuits have become important components in today's IC designs which demands extremely high integration density and reliability under process variations. The most challenging task is how to accurately estimate the small failure probability of memory where circuit a "rare event". Classic importance sampling has been widely recognized be inaccurate unreliable dimensions. To address this issue, we propose fast statistical analysis rare events dimensions prove that estimation always...
Non-malignant mammary epithelial cells (MECs) undergo acinar morphogenesis in three-dimensional Matrigel culture, a trait that is lost upon oncogenic transformation. Rho GTPases are thought to play important roles regulating cell-cell junctions, but their contributions remain unclear. Here we report the activity of down-regulated non-malignant MECs culture with particular suppression Rac1 and Cdc42. Inducible expression constitutively active form Vav2, GTPase guanine nucleotide exchange...
Being an effective edge detector with single-pixel response, Canny operator has been widely used in accurately abstracting the information image processing. However, taking its 4-step process into account, real-time implementation based on CPU become a significant problem, especially for part of tracing, which consumes large amount computing time. To solve GPU will be this paper sake powerful ability parallel processing while new is proposed introduction breakpoints detection and tracing...
Based on the lithologies, sedimentary structures, graptolite zones, inorganic geochemical characteristics, electrical data of 110 shale gas wells in southern Sichuan Basin and mineral quantitative analysis technology scanning electron microscope, stratigraphic sequences Upper Ordovician Katian Stage–Himantian Stage–Silurian Rhuddanian Stage–Aeronian Stage are divided, characteristics fourth-order sequence evolution analyzed. The target layer can be divided into two sequences, namely SQ1 SQ2....
Abstract Background Intracranial internal carotid artery (ICA) calcification is a common incidental finding in non-contrast head CT. We evaluated the predictive value of ICAC (ICAC) for future risk cognitive decline and compared results with conventional imaging biomarkers dementia. Methods In retrospective observational cohort, we included 230 participants PET-CT scan within 18 months baseline clinical assessment longitudinal assessments. was quantified on CT scans using Agatson calcium...
The standard and layout-hardened D filp-flops (DFFs) named DFF1-6 were designed manufactured based on an advanced 22-nm ultrathin body buried oxide fully depleted silicon-on-insulator (UTBB FD-SOI) technology. Heavy-ion irradiation results indicate that FD-SOI technology has contributions to radiation hardness the hardened DFFs have higher single-event upset (SEU) tolerance than DFF. upsets induced by embedded SET targets are strongly dependent testing frequency. layout separating dual...