A5088321414- Trigeminal Neuralgia and Treatments
- Neurosurgical Procedures and Complications
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Intracranial Aneurysms: Treatment and Complications
- Sexual function and dysfunction studies
- Facial Nerve Paralysis Treatment and Research
- HIV-related health complications and treatments
- Pain Mechanisms and Treatments
- Obstructive Sleep Apnea Research
- Traumatic Brain Injury and Neurovascular Disturbances
- HIV Research and Treatment
- Moyamoya disease diagnosis and treatment
- Muscle Physiology and Disorders
- Vascular Malformations Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Migraine and Headache Studies
- Neurological and metabolic disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurological Complications and Syndromes
- Epilepsy research and treatment
- Voice and Speech Disorders
- Inflammatory Myopathies and Dermatomyositis
- Cardiac Arrest and Resuscitation
Johns Hopkins University
2023-2025
Johns Hopkins Medicine
2023-2025
Washington University in St. Louis
2019-2024
Inclusion body myositis (IBM) is an idiopathic inflammatory myopathy with muscle pathology characterized by endomysial inflammation, rimmed vacuoles, and cytoplasmic mislocalization of transactive response DNA-binding protein 43 (TDP-43). We aimed to determine whether loss TDP-43 splicing repression led the production "cryptic peptides" that could be detected in biopsies as a useful biomarker for IBM.
Amyloidosis, including cerebral amyloid angiopathy, and markers of small vessel disease (SVD) vary across dominantly inherited Alzheimer's (DIAD) presenilin-1 (PSEN1) mutation carriers. We investigated how position relative to codon 200 (pre-/postcodon 200) influences these pathologic features dementia at different stages. Individuals from families with known PSEN1 mutations (n = 393) underwent neuroimaging clinical assessments. cross-sectionally evaluated regional Pittsburgh compound...
OBJECTIVE Although trigeminal neuralgia (TN) is initially managed conservatively, approximately half of all patients will eventually undergo surgery. Despite this outcome, there limited understanding the relationship between preoperative length conservative management and pain outcomes after microvascular decompression (MVD). In study, authors aimed to describe duration postoperative in undergoing MVD for TN. METHODS The electronic medical records 381 with TN who underwent primary at...
BACKGROUND AND OBJECTIVES: Although the association between multiple sclerosis and trigeminal neuralgia (TN) is well established, little known about TN pain characteristics postoperative outcomes after microvascular decompression (MVD) in patients with other autoimmune diseases. In this study, we aim to describe presenting concomitant disease who underwent an MVD. METHODS: A retrospective review of all MVD at our institution 2007 2020 was conducted. The presence type were recorded for each...
Objective: This study examined relationships between anticholinergic medication burden and brain integrity in people living with HIV (PLWH) without (HIV−). Methods: Neuropsychological performance z -scores (learning, retention, executive function, motor/psychomotor speed, language domains, global cognition), neuroimaging measures (brain volumetrics white matter fractional anisotropy) were analyzed PLWH ( n = 209) HIV− 95) grouped according to the Anticholinergic Cognitive Burden (ACB) scale...
Hyperphosphorylation of tau leads to conformational changes that destabilize microtubules and hinder axonal transport in Alzheimer's disease (AD). However, it remains unknown whether white matter (WM) decline due AD is associated with specific Tau phosphorylation site(s).
BACKGROUND AND OBJECTIVES: Nosocomial infections are the most common complication among critically ill patients and contribute to poor long-term outcomes. Patients with aneurysmal subarachnoid hemorrhage (aSAH) highly susceptible perioperative infections, yet it is unclear what factors influence infection onset functional recovery. The objective was investigate risk for after aSAH relate causative pathogens patient METHODS: Clinical records were obtained 194 adult treated at our institution...
The prescription of opioid analgesics for trigeminal neuralgia (TN) is controversial, and their effect on postoperative outcomes patients with TN undergoing microvascular decompression (MVD) has not been reported. We aimed to describe the relationship between preoperative use in MVD.
BACKGROUND AND OBJECTIVES: Percutaneous rhizotomy may be an effective primary intervention in patients with trigeminal neuralgia who are poor candidates for microvascular decompression or those desire a less invasive approach. However, the influence of neurovascular compression on pain-free survival after percutaneous is not well understood. METHODS: We retrospectively reviewed all undergoing at our institution from 1995 to 2022. Patients were included if they had no history surgical...
Abstract Background Persons with HIV (PWH) are at increased risk of frailty, a clinically recognizable state vulnerability resulting from aging-associated decline in multiple physiologic systems. Frailty is often defined by the Fried criteria, which includes subjective and objective standards concerning health resiliency. However, these frailty metrics do not incorporate cognitive performance or neuroimaging measures. Methods We compared structural (diffusion tensor imaging [DTI]) functional...
OBJECTIVE Recently, two scoring systems have been developed for predicting pain-free outcomes after microvascular decompression (MVD). Evaluation of these scores on large external datasets has limited. In this study, the authors aimed to evaluate performance published MVD in outcome. METHODS A total 458 patients who underwent trigeminal neuralgia (TN) between 2007 and 2020 had at least 6 months follow-up were included study. Hardaway Panczykowski retrospectively computed each patient...
Background: Postoperative stroke is a potentially devastating neurological complication following surgical revascularization for Moyamoya disease. We sought to evaluate whether peri-operative hemoglobin levels were associated with the risk of early post-operative surgery in adult patients. Methods: Adult patients having surgeries disease between 1999-2022 identified through single institutional retrospective review. Logistic regression analysis was used test association drop and...
BACKGROUND AND OBJECTIVES: The influence of prior stereotactic radiosurgery (SRS) on outcomes subsequent microvascular decompression (MVD) for patients with trigeminal neuralgia (TN) is not well understood. To directly compare pain in undergoing primary MVD vs those a history 1 SRS procedure. METHODS: We retrospectively reviewed all at our institution from 2007 to 2020. Patients were included if they underwent or had alone before MVD. Barrow Neurological Institute (BNI) scores assigned...
BACKGROUND AND OBJECTIVES: Subdural hematoma (SDH) patients with end-stage renal disease (ESRD) require replacement therapy in addition to neurological management. We sought determine whether continuous venovenous hemodialysis (CVVHD) or intermittent (iHD) is associated higher rates of SDH re-expansion as well morbidity and mortality. METHODS: Hemodialysis-dependent ESRD who were discovered have an retrospectively identified from 2016 2022. Rates expansion during CVVHD vs iHD compared....
Despite improved survival rates, neurocognitive impairment persists in persons living with HIV (PLWH). An active lifestyle is linked to cognition among PLWH, yet the neural substrates remain unclear. Diffusion tensor imaging and diffusion basis spectrum measure HIV-related changes brain white matter integrity. We used these measures of structural integrity assess changes, physical fitness, a cross-sectional study PLWH.
Abstract Background Vascular dysfunction can compound white matter damage in an Alzheimer disease (AD) cohort, leading to the formation of hyperintensities (WMHs). The spatial distribution WMHs at various stages is interest, as previous work has found that patients with late‐onset AD show earliest changes posterior regions. We evaluated whether volumetric and microstructural within normal‐appearing were associated biomarkers for AD. Method T2‐weighted‐Fluid‐Attenuated Inversion Recovery...
OBJECTIVE Microvascular decompression (MVD) is an effective intervention in patients with trigeminal neuralgia (TN). How prior rhizotomy can impact long-term pain outcomes following MVD not well understood. In this study, the authors sought to compare who had undergone primary versus those secondary after a single or multiple rhizotomies. METHODS The retrospectively reviewed data on all at their institution from 2007 2020. Patients were included study if they surgical history was notable for...
INTRODUCTION: In most cases of trigeminal neuralgia (TN), the nerve is compressed by arterial vasculature. METHODS: We retrospectively reviewed all patients undergoing microvascular decompression at our institution, identifying with either sole or venous compression. dichotomized into groups and obtained demographics postoperative complications for each case. Barrow Neurological Index (BNI) pain scores were collected preoperatively, postoperatively, final follow-up, as well recurrence pain....
Hyperphosphorylation of tau leads to conformational changes that destabilize microtubules and hinder axonal transport in Alzheimer disease(AD). Tau can be phosphorylated at multiple positions vary over AD disease stage may quantify severity pathology or neurodegeration. We evaluated whether phosphorylation three sites (pt217, pt181, pt205) total associated with white matter track (WMT) integrity within autosomal dominant AD(ADAD). ADAD are a younger cohort exhibit fewer age-related...