A5046853912- Ubiquitin and proteasome pathways
- HER2/EGFR in Cancer Research
- NF-κB Signaling Pathways
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- T-cell and Retrovirus Studies
- Wnt/β-catenin signaling in development and cancer
- Breast Cancer Treatment Studies
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA regulation and disease
- Chronic Myeloid Leukemia Treatments
- Endoplasmic Reticulum Stress and Disease
- Immune Response and Inflammation
- Sexual Differentiation and Disorders
- Acute Myeloid Leukemia Research
Cornell University
2021-2023
University of Nebraska Medical Center
2011-2016
The E3 ubiquitin ligase Casitas B lymphoma protein (Cbl) controls the ubiquitin-dependent degradation of EGF receptor (EGFR), but its role in regulating downstream signaling elements with which it associates and impact on biological outcomes EGFR are less clear. Here, we demonstrate that stimulation human mammary epithelial cells disrupts adherens junctions (AJs) through Vav2 Rac1/Cdc42 activation. In EGF-stimulated cells, Cbl regulates levels phosphorylated thereby attenuating activity....
Mayumi Naramura 1,2 , Scott Nadeau Bhopal Mohapatra 1,3 Gulzar Ahmad 1 Chandrani Mukhopadhyay Martin Sattler 5 Srikumar M Raja Amarnath Natarajan 1,4 Vimla Band Hamid 1,2,3 Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 2 Department Genetics, Cell Biology Anatomy, College Medicine, 3 Biochemistry & Molecular Biology, 4 Pharmaceutical Sciences, Pharmacy, Dana Farber Institute, Harvard School, Boston, MA Keywords: Cbl, E3 ubiquitin...
Abstract SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key substrates mediating oncogenic function. However, the mechanisms underlying SPOP regulation are largely unknown. Here, we have identified G3BP1 interactor of and functions competitive inhibitor Cul3 , suggesting distinctive mode inactivation in prostate cancer (PCa). Transcriptomic analysis functional studies reveal G3BP1-SPOP signaling axis that promotes PCa progression through activating AR...
Based on gene expression patterns, breast cancers can be divided into subtypes that closely resemble various developmental stages of normal mammary epithelial cells (MECs). Thus, understanding molecular mechanisms MEC development is expected to provide critical insights initiation and progression cancer. Epidermal growth factor receptor (EGFR) its ligands play essential roles in pathological gland. Signals through EGFR required for gland development. Ligands are over-expressed a significant...
Casitas B-cell lymphoma (Cbl) family ubiquitin ligases negatively regulate tyrosine kinase-dependent signal transduction by promoting degradation of active kinases. We and others previously reported that loss Cbl functions caused hyperproliferation in lymphoid hematopoietic systems. Unexpectedly, deletion Cbl-b-null, Cbl-c-null primary mouse mammary epithelial cells (MECs) (Cbl triple-deficiency) induced rapid cell death despite enhanced MAP kinase AKT activation. Acute triple-deficiency...
Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3SPOP), acts as prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur 10% of primary prostate cancer with high Gleason grade and poor prognosis. However, it is unclear how the activity controlled dysregulation contributes to malignant transformation. Here, we identified GTPase Activating Protein (SH3 Domain) Binding 1 (G3BP1) an interactor upstream regulator CUL3SPOP, functions inhibitor CUL3SPOP...