A5079263920- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Blood transfusion and management
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Blood donation and transfusion practices
- Abdominal Trauma and Injuries
- Hemophilia Treatment and Research
- Global Cancer Incidence and Screening
- Maternal and fetal healthcare
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Arrest and Resuscitation
- Economic and Financial Impacts of Cancer
- Blood groups and transfusion
- Hemostasis and retained surgical items
- Pregnancy and preeclampsia studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemoglobinopathies and Related Disorders
- Breast Cancer Treatment Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Blood disorders and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vitamin K Research Studies
Queen Mary University of London
2016-2025
NHS Blood and Transplant
2016-2025
Barts Health NHS Trust
2016-2025
National Health Service
2018-2025
University of North Carolina at Chapel Hill
2021-2024
Public Health Wales
2024
UNC Lineberger Comprehensive Cancer Center
2022-2023
Velindre Cancer Centre
2023
Chonnam National University Hwasun Hospital
2023
Royal London Hospital
2020-2021
Prolonged aPTT in Patients with Covid-19 In this study, 20% of patients had a prolonged activated partial-thromboplastin time. 90% these cases, the cause was lupus anticoagulant...
Importance Critical bleeding is associated with a high mortality rate in patients trauma. Hemorrhage exacerbated by complex derangement of coagulation, including an acute fibrinogen deficiency. Management replacement cryoprecipitate transfusions or concentrate, usually administered relatively late during hemorrhage. Objective To assess whether survival could be improved administering early and empirical dose to all trauma that required activation major hemorrhage protocol. Design, Setting,...
The aim of this study was to identify the effects recent innovations in trauma major hemorrhage management on outcome and transfusion practice, determine contemporary timings patterns death.
To ascertain the incidence of massive transfusion (MT) in obstetrics UK, and describe its management clinical outcomes.A population-based cross-sectional study conducted through UK Obstetric Surveillance System (UKOSS).All hospitals with consultant-led maternity units.Any pregnant woman at ≥20 weeks gestation receiving ≥8 units red blood cells within 24 hours giving birth, from July 2012 to June 2013.Prospective case identification monthly mailing UKOSS.We identified 181 women who had...
Current management principles of hemorrhagic shock after trauma emphasize earlier transfusion therapy to prevent dilution clotting factors and correct coagulopathy. London's Air Ambulance (LAA) was the first UK civilian prehospital service routinely offer red blood cell (RBC) (phRTx). We investigated effect phRTx on mortality.Retrospective database study comparing mortality before implementation with in exsanguinating patients. Univariate logistic regression performed for unadjusted...
Abstract Background In-hospital acute resuscitation in trauma has evolved toward early and balanced transfusion with red blood cells (RBC) plasma being transfused equal ratios. Being able to deliver this ratio prehospital environments is a challenge. A combined component, like leukocyte-depleted cell (RCP), could facilitate RBC plasma, while at the same time improving logistics for team. However, there limited evidence on clinical benefits of RCP. Objective To compare RCP versus alone or...
In clinical trials of dabigatran and rivaroxaban for stroke prevention in atrial fibrillation (AF), drug eligibility dosing were determined using the Cockcroft-Gault equation to estimate creatine clearance as a measure renal function. This cross-sectional study aimed compare whether estimated glomerular filtration rate (eGFR) by widely available used Modified Diet Renal Disease (MDRD) would alter prescribing or renally excreted new oral anticoagulants.Of 4712 patients with known AF within...
Summary Understanding the coagulopathy of major‐obstetric‐haemorrhage ( MOH ) that leads to massive‐transfusion MT is fundamental improving outcomes. This study reports on haematological features and transfusion management women experiencing [defined as ≥8 units red blood cells RBC within 24 h delivery]. One hundred eighty‐one cases [median (interquartile range; IQR age 33 years (29–36)] were identified from all UK hospitals, using Obstetric Surveillance System between July 2012 June 2013....
Compare 30-day mortality among patients receiving the specific reversal agent andexanet alfa versus replacement prothrombin complex concentrate (PCC) in management of direct-acting oral anticoagulant (DOAC)-related bleeds.
Platelets play a critical role in hemostasis with aberrant function implicated trauma-induced coagulopathy. However, the impact of massive transfusion protocols on platelet during trauma hemorrhage is unknown. The aim this study was to characterize effects aggregation and fibrinolytic markers hemostatic resuscitation.Trauma patients enrolled into prospective Activation Coagulation Inflammation Trauma between January 2008 November 2015 who received at least four units packed red blood cells...
Summary The emerging COVID‐19 pandemic has overwhelmed healthcare resources worldwide, and for transfusion services this could potentially result in rapid imbalance between supply demand due to a severe shortage of blood donors. This may insufficient components meet every patient's needs resulting difficult decisions about which patients with major bleeding do not receive active support. document, was prepared on behalf the National Blood Transfusion Committee England, provides framework...
Early blood transfusion improves survival in patients with life-threatening bleeding, but the optimal strategy pre-hospital setting has yet to be established. Although there is some evidence of benefit use whole blood, have been no randomised controlled trials exploring clinical and cost effectiveness administration versus component therapy for trauma bleeding. The aim this trial determine whether leukocyte-depleted better than standard care (blood transfusion) reducing proportion...
There is renewed interest in the use of whole blood (WB) for resuscitation trauma patients. Platelet function stored WB compared to platelet concentrates not well established and was assessed vitro this study.Leucocyte-depleted cold-stored (CS-WB) prepared using a Terumo WB-SP Imuflex kit held at 2-6°C alongside: (A) UK standard pooled platelets 20-24°C (RT-PLTS), (B) (CS-PLTS), (C) platelet-rich plasma produced (CS-PRP), 21 days. A series assays were function.Platelet count retained 57 ±...