A5043940087- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Sleep and Wakefulness Research
- COVID-19 and Mental Health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Blood donation and transfusion practices
- Migration, Health and Trauma
- Trauma and Emergency Care Studies
- Abdominal Trauma and Injuries
- Posttraumatic Stress Disorder Research
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sleep and related disorders
- Pediatric Pain Management Techniques
- Disaster Response and Management
- Neurosurgical Procedures and Complications
- Patient Safety and Medication Errors
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Hospital Admissions and Outcomes
- Neuroscience of respiration and sleep
- Health Sciences Research and Education
- Intracerebral and Subarachnoid Hemorrhage Research
- Heart Failure Treatment and Management
- Medical Research and Practices
Oxford University Hospitals NHS Trust
2019-2024
John Radcliffe Hospital
2004-2023
3M (United States)
2019
University of Toronto
2019
Hospital for Sick Children
2019
King's College - North Carolina
2019
King's College London
2019
University of Oxford
2015-2019
Sepsis arises from diverse and incompletely understood dysregulated host response processes following infection that leads to life-threatening organ dysfunction. Here we showed neutrophils emergency granulopoiesis drove a maladaptive during sepsis. We generated whole-blood single-cell multiomic atlas (272,993 cells, n = 39 individuals) of the sepsis immune identified populations immunosuppressive mature immature neutrophils. In co-culture, CD66b+ inhibited proliferation activation CD4+ T...
Importance Critical bleeding is associated with a high mortality rate in patients trauma. Hemorrhage exacerbated by complex derangement of coagulation, including an acute fibrinogen deficiency. Management replacement cryoprecipitate transfusions or concentrate, usually administered relatively late during hemorrhage. Objective To assess whether survival could be improved administering early and empirical dose to all trauma that required activation major hemorrhage protocol. Design, Setting,...
Intrusive memories of psychological trauma are a core clinical feature posttraumatic stress disorder (PTSD), and in the early period post-trauma may be potential target for intervention. Disrupted sleep weeks is associated with later PTSD. The impact intrusive immediately post-trauma, their relation to PTSD, unknown. This study assessed relationship between duration on first night following real-life traumatic event subsequent week, how these might relate PTSD symptoms at 2 months. Patients...
Early tranexamic acid (TXA) treatment reduces head injury deaths after traumatic brain (TBI). We used scans that were acquired as part of the routine clinical practice during CRASH-3 trial (before unblinding) to examine mechanism action TXA in TBI. Specifically, we explored potential effects on intracranial haemorrhage and infarction.This is a prospective substudy nested within trial, randomised placebo-controlled (loading dose 1 g over 10 min, then infusion 8 hours) patients with isolated...
Acute upper gastrointestinal bleeding (AUGIB) is the commonest reason for hospitalization with hemorrhage in UK and leading indication transfusion of red blood cells (RBCs). Observational studies suggest an association between more liberal RBC adverse patient outcomes, a recent randomised trial reported increased further mortality policy. TRIGGER (Transfusion Gastrointestinal Bleeding) pragmatic, cluster randomized which aims to evaluate feasibility safety implementing restrictive versus...
Pulmonary embolism (PE) is a common and potentially fatal condition. The case presented of young woman who to the emergency department with first-time seizures. On further investigation corroborated by post-mortem findings, this was found be manifestation PE. purpose report highlight clinical community that PE can present in varied fashion that, because this, its diagnosis occasionally delayed. Vigilance advised expert acumen needed non-smoking persons previously normal respiratory...
Abstract This article describes a working partnership between the Cairns Clinical Librarian Service, Health Care Libraries, University of Oxford and Emergency Department (ED) at John Radcliffe Hospital, Oxford. collaboration resulted in establishment guideline development group June 2002. The aim is to produce set easily accessible, user‐orientated, evidence‐based guidelines for use clinicians Department, within realistic timescale. Project was built on previous models clinical librarianship...
Abstract Background Acute heart failure patients are often encountered in emergency departments (ED) from 11% to 57% using medical services (EMS). Our aim was evaluate the association of EMS use with acute patients’ ED management and short-term outcomes. Methods This a sub-analysis European EURODEM study. Data on presenting dyspnoea were collected prospectively EDs. Patients diagnosis categorized into two groups: those self-presenting (non- EMS). The independent between 30-day mortality...
Acute pain is a common reason for emergency department (ED) attendance. Royal College of Emergency Medicine (RCEM) management audits have shown national variation and room improvement. Previous evidence suggests that children receive less satisfactory than adults.Prescription analgesia in medicine cross-sectional observational study consecutive patients presenting to 12 National Health Service EDs with an isolated long bone fracture and/or dislocation, was carried out between 2015 2017....
The objective of this study was to identify staff perceptions a service improvement for pediatric emergency care at university teaching hospital. Semistructured qualitative interviews stakeholders were conducted, and grounded theory approach used analysis. Forty-one conducted with physicians, nurses, managers, health workers. Major themes emerging from the analysis included physical space flow within department (ED), impact technology, staffing in ED, effects frontline pediatricians...
<sec> <title>BACKGROUND</title> Frontline health care staff are frequently exposed to traumatic events as part of their work. Although this study commenced before the emergence COVID-19, levels exposure were heightened by pandemic. Many members report intrusive memories such events, which can elicit distress, affect functioning, and be associated with posttraumatic stress disorder symptoms in long term. We need evidence-based interventions that brief, preventative, nonstigmatizing, suitable...
Background Frontline health care staff are frequently exposed to traumatic events as part of their work. Although this study commenced before the emergence COVID-19, levels exposure were heightened by pandemic. Many members report intrusive memories such events, which can elicit distress, affect functioning, and be associated with posttraumatic stress disorder symptoms in long term. We need evidence-based interventions that brief, preventative, nonstigmatizing, suitable for working lives...
Acute pain is one of the most commonly cited reasons for attendance to emergency department (ED), and Royal College Emergency Medicine (RCEM) Best Practice Guideline (2014) acknowledged that current management acute in UK EDs inadequate has a poor evidence base.The Prescription Of analgesia (POEM) survey cross-sectional observational consecutive patients presenting 12 National Health Service (NHS) with limb fracture and/or dislocation England Scotland was carried out between 2015 2017. The...