A5083503699- Breast Lesions and Carcinomas
- Renal cell carcinoma treatment
- Breast Cancer Treatment Studies
- Renal and related cancers
- Cancer and Skin Lesions
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Bladder and Urothelial Cancer Treatments
- Cancer-related gene regulation
- Sarcoma Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Lung Cancer Research Studies
- Metastasis and carcinoma case studies
- Testicular diseases and treatments
- Molecular Biology Techniques and Applications
- Colorectal and Anal Carcinomas
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Wnt/β-catenin signaling in development and cancer
- Viral-associated cancers and disorders
- Neurofibromatosis and Schwannoma Cases
- scientometrics and bibliometrics research
- Meta-analysis and systematic reviews
University of Sarajevo
2014-2024
Institute of Oncology Ljubljana
2024
Qatar University
2022-2024
University of Miami
2024
Sarajevo School of Science and Technology
2022-2023
University of Kansas Medical Center
2022
International University of Sarajevo
2022
Clinical Center University of Sarajevo
2012-2021
University Hospital Dubrava
2015
University Hospital Plzen
2015
Abstract Background Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV), known oncoviruses, can be co-present cooperate in the initiation and/or progression of human carcinomas, including head neck. Based on this fact, we recently reported prevalence both HPVs EBV cervical breast cancers. Methods We herein explore for first time co-prevalence high-risk 98 neck (HN) squamous cell carcinoma (SCC) tissues from Bosnian patients using polymerase chain reaction (PCR) immunohistochemistry...
IntroductionSpindle cell carcinoma is a rare subtype of metaplastic breast cancer, with triple-negative (TNBC: estrogen receptor-negative/progesterone receptor-negative/human epidermal growth factor receptor 2-negative) phenotype. It associated marked resistance to conventional chemotherapy and has an overall poor outcome.Materials MethodsTwenty-three pure spindle carcinomas the (18 primary 5 recurrent/metastatic) were comprehensively explored for biomarkers immuno-oncology targeted...
Colorectal cancer (CRC) is a common malignancy with high mortality rate worldwide. It complex, multifactorial disease that strongly impacted by both hereditary and environmental factors. The role of microbes (e.g., viruses) in the pathogenesis CRC poorly understood. In current study, we explored status high-risk human papillomaviruses (HPV) Epstein–Barr virus (EBV) well-defined cohort using immunohistochemistry polymerase chain reaction assays. Our data showed HPVs were (~80%) EBV had low...
Renal oncocytoma (RO) may present with a tubulocystic growth in 3% to 7% of cases, and such cases its morphology significantly overlap renal cell carcinoma (TCRCC). We compared the morphologic immunohistochemical characteristics these tumors, aiming clarify differential diagnostic criteria, which facilitate discrimination RO from TCRCC. Twenty-four cystic ROs 15 TCRCCs were selected analyzed for: architectural patterns, stromal features, cytomorphology, ISUP nucleolar grade, necrosis,...
We have studied a cohort of renal cell carcinomas (RCCs) with smooth-muscle stroma (N=6), which lacked any following genetic aberrations: mutations in the VHL-gene-coding sequence, loss heterozygosity chromosome 3p, or hypermethylation VHL. Using targeted next-generation sequencing, no intronic VHL selected genes involved angiogenesis and frequently mutated clear RCC were identified. Tumors also tested for presence hotspot TCEB1 gene negative results all cases. conclude that there exists...
Metastatic Leydig cell tumors (LCT) are rare, difficult-to-treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic profiling for detection therapeutic targets, which was then followed by investigation into a cohort additional LCTs.Twenty-nine (27 male and 2 female patients) were profiled using next-generation sequencing immunohistochemistry.TERT fusions detected only in testicular LCTs, 3 7...
In the current study, we assessed prevalence and molecular features of HER2-low phenotype in apocrine carcinomas breast (ApoCa) its relationship with tumor-infiltrating lymphocytes (TILs). A cohort 64 well-characterized therapy-naïve ApoCa was used. The TIL distribution using hematoxylin eosin whole slide/scanned images following international TILs working group recommendations. Next-generation sequencing (NGS) performed a subset ApoCa. All patients were women, mean age 62 years. Forty-three...
The characteristic morphologic spectrum of tubulocystic renal cell carcinoma (TC-RCC) may include areas resembling papillary RCC (PRCC). Our study includes 15 RCCs with pattern: 6 TC-RCCs, 1 RCC-high grade architecture, 5 TC-RCCs foci PRCC, 2 high-grade (HGRCC) not otherwise specified, and a clear RCC/renal angiomyoadenomatous tumor-like component. We analyzed aberrations chromosomes 7, 17, Y; mutations VHL FH genes; loss heterozygosity at chromosome 3p. Genetic analysis was performed...
<title>Abstract</title> Purpose Acinic cell carcinoma (ACC) of the breast is a very rare, primary salivary gland-type malignancy with ~ 100 reported cases in literature. Limited information about clinical features and outcomes patients ACC available. Methods We utilized Surveillance, Epidemiology, End Results (SEER) database to identify diagnosed between 2000 2018. For comparison, we also examined cohort invasive carcinomas no special type (NST). Thirty were identified among over 248,000 NST...
Metanephric adenoma (MA) is a rare benign renal neoplasm. On occasion, MA can be difficult to differentiate from malignancies such as papillary cell carcinoma in adults and Wilms̕ tumor children. Despite recent advancements genomics, there limited data available regarding the genetic alterations characteristic of MA. The purpose this study determine frequency metanephric cases exhibiting cytogenetic aberration t (9;15)(p24;q24), investigate association between (9,15) BRAF mutation...