A5028139879- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Renal Transplantation Outcomes and Treatments
- Cardiovascular and exercise physiology
- Organ Transplantation Techniques and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Renal and Vascular Pathologies
- Primary Care and Health Outcomes
- Pregnancy and Medication Impact
- Heart Rate Variability and Autonomic Control
- Chronic Disease Management Strategies
- Healthcare Policy and Management
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Healthcare Systems and Technology
- Telemedicine and Telehealth Implementation
- Cardiovascular Syncope and Autonomic Disorders
- Hemodynamic Monitoring and Therapy
- Physical Activity and Health
- Transplantation: Methods and Outcomes
- Pharmacological Effects and Toxicity Studies
- Healthcare cost, quality, practices
East Kent Hospitals University NHS Foundation Trust
2014-2024
University of Kent
2016-2024
Baylor Scott & White Health
2011-2023
University Foundation
2017
Kent and Canterbury Hospital
1997-2016
King's College London
2006-2014
National Kidney Foundation
2014
ENT and Allergy
2013
Mayo Clinic
2006-2012
Kent State University
2012
Kidney disease is an important public health problem. Both acute kidney injury (AKI) and chronic have been well defined classified, leading to improved research efforts subsequent management strategies recommendations. For those patients with abnormalities in function and/or structure who meet neither the definition of AKI nor disease, there remains a gap research, care, guidance. The term diseases disorders, abbreviated (AKD), has introduced as construct address this. To expand harmonize...
The complement system has a critical role in both the innate and adaptive immune responses. In humans, C3 exists as two main allotypes, F (fast) S (slow), which are known to affect incidence of inflammatory disease. We conducted study address influence these alleles on late renal-graft outcome.
Abstract Hypertension is recognised as a leading attributable risk factor for cardiovascular disease and premature mortality. Global initiatives towards the prevention treatment of arterial hypertension are centred around non-pharmacological lifestyle modification. Exercise recommendations differ between professional scientific organisations, but generally unanimous on primary role traditional aerobic dynamic resistance exercise. In recent years, isometric exercise training (IET) has emerged...
BACKGROUND: Ambulatory blood pressure recordings have been shown to correlate better with target organ damage than isolated clinic readings. There some small studies demonstrating that abnormal diurnal rhythm is common in uraemia and patients on renal replacement therapy. Abnormal itself may be a risk factor for accelerated damage. METHODS: We retrospectively studied 480 ambulatory 380 essential hypertension, secondary examined each group. RESULTS: (non-dipping) significantly more prevalent...
People with multiple sclerosis, paraplegia and neural tube defects typically have neurogenic lower urinary tract dysfunction (NLUTD). This encompasses detrusor hyperreflexia or without sphincter dyssynergia hypo- acontractility. Their effects undermine safe, effective controlled storage voiding of urine predispose to reflux nephropathy. Therefore, patients in these diagnostic groups NLUTD would be expected increased risk renal failure. The aim this study was quantify using the General...
Abstract Aims To compare rates of chronic kidney disease (CKD) in patients with diabetes and management risk factors compared people without using general practice computer records, to assess the utility serum creatinine albuminuria as markers impaired renal function. Methods The simplified Modification Diet Renal Disease (MDRD) equation was used estimate glomerular filtration rate (eGFR) stage CKD. Further data were extracted how effectively function being identified well potentially...
BackgroundIt is unclear what degree of change in the eGFR over a 1-year period indicates clinically significant progression, and whether this adds additional information beyond that obtained by single measure alone.
Acute kidney injury (AKI) is a common clinical problem. Studies have documented the incidence of AKI in variety populations but to date we do not believe real has been accurately district general hospital setting. The aim here was describe detected typical setting an unselected population, and associated short long-term outcomes. A retrospective observational database study from secondary care East Kent (adult catchment population 582,300). All adult patients (18 years or over) admitted...
Hypertensive non-diabetic patients who lack the normal nocturnal decline in blood pressure ('non-dippers') have an increased incidence of cardiovascular complications. Poor control is known to exacerbate glomerular filtration rate with diabetic nephropathy.The aim this study was assess contribution abnormal diurnal rhythm progression nephropathy. We retrospectively studied 26 hypertension, proteinuria and relentless progressive impairment renal function due nephropathy between 1990 1996....
TODD KATZNER,1,2,26 BRIAN W. SMITH,3 TRICIA A. MILLER,4,5 DAVID BRANDES,6 JEFF COOPER,7 MICHAEL LANZONE,5,8 DANIEL BRAUNING,9 CHRISTOPHER FARMER,10 SERGIO HARDING,11 E. KRAMAR,12 CRAIG KOPPIE,13 CHARLES MAISONNEUVE,14 MARK MARTELL,15 ELIZABETH K. MOJICA,16 CHARLIE TODD,17 JUNIOR TREMBLAY,18 MARIA WHEELER,19 F. BRINKER,20 TONY CHUBBS,21 ROLF GUBLER,22 KIERAN O’MALLEY,23 SCOTT MEHUS,24 BRADY PORTER,19 ROBERT P. BROOKS,4 BRYAN D. WATTS,16 AND KEITH L. BILDSTEIN25
Background. The mechanisms controlling the production of antibodies against histocompatibility antigens are prime importance in organ transplantation. Methods. We investigated role complement response to allogeneic stimulation, using mice deficient C3, C4, or C5 dissect alternative, classical, and terminal pathways. Results. After fully major complex disparate skin grafts, allospecific immunoglobulin (Ig)G was markedly impaired C3- C4-, but not C5-deficient mice. This defect most pronounced...
<b><i>Background:</i></b> Serum creatinine is routinely measured to estimate glomerular filtration rate (GFR). Long-term cohort studies report that death a likelier outcome than progression kidney failure. However, it unclear how short-term changes in estimated GFR (eGFR) over 1-year period relate subsequent mortality risk. <b><i>Methods:</i></b> Using provincial laboratory registry from Alberta, Canada, we identified 598,397 adults who had ≥2...
The implementation of national estimated glomerular filatration rate reporting and the inclusion renal-specific indicators in a primary care pay for performance (P4P) system since April 2006 has promoted identification better management risk factors related to chronic kidney disease (CKD). In UK, P4P framework is known as Quality Outcomes Framework (QOF). One key targets intervention was hypertension. It clear that hypertension major predictor development progression CKD; thus, targeting...
Abstract BACKGROUND Identification of acute kidney injury (AKI) is predominantly based on changes in plasma creatinine concentration, an insensitive marker. Alternative biomarkers have been proposed. The reference change value (RCV), the point at which biomarker can be inferred to occurred with statistical certainty, provides objective assessment serial tests results individual. METHODS In 80 patients chronic disease, weekly measurements blood and urinary concentrations were undertaken over...
Acute T-cell mediated rejection (TCMR) is usually indicated by alteration in serum-creatinine measurements when considerable transplant damage has already occurred. There is, therefore, a need for non-invasive early detection of immune signals that would precede the onset rejection, prior to damage.
Background Acute kidney injury (AKI) is a common clinical problem with significant morbidity and mortality. All hospitalised patients are at risk. AKI often preventable reversible; however, the 2009 National Confidential Enquiry into Patient Outcome Death highlighted systematic failings of identification management, recommended risk assessment all emergency admissions. Objectives To develop three predictive models to stratify (1) on arrival in hospital; (2) developing during admission; (3)...
E-cadherin is a transmembrane protein that maintains intercellular contacts and cell polarity in epithelial tissue. The down-regulation of contributes to the induction epithelial-to-mesenchymal transition (EMT), resulting an increased potential for cellular invasion surrounding tissues entry into bloodstream. Loss has been observed variety human tumors as result somatic mutations, chromosomal deletions, silencing CDH1 gene promoter, proteolytic cleavage. To date, no compounds directly...