Sameep Sehgal
A5076160536- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- Sarcoidosis and Beryllium Toxicity Research
- Organ and Tissue Transplantation Research
- Mechanical Circulatory Support Devices
- Long-Term Effects of COVID-19
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Eosinophilic Disorders and Syndromes
- Medical Imaging and Pathology Studies
- Respiratory viral infections research
- Cancer Immunotherapy and Biomarkers
- COVID-19 Impact on Reproduction
- Heparin-Induced Thrombocytopenia and Thrombosis
- Respiratory and Cough-Related Research
- Fungal Infections and Studies
- Asthma and respiratory diseases
Cleveland Clinic
2015-2024
Lady Hardinge Medical College
2024
Temple University Hospital
2020-2022
Temple University
2018-2021
Philadelphia University
2021
Temple University Health System
2020
Sir Ganga Ram Hospital
2005
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has led to significant reductions in transplantation, motivated part by concerns of disproportionately more severe among solid organ transplant (SOT) recipients. However, clinical features, outcomes, and predictors mortality SOT recipients are not well described. Methods We performed a multicenter cohort study with laboratory-confirmed COVID-19. Data were collected using standardized intake 28-day follow-up electronic case...
Effective treatments for patients with severe COVID-19 are needed.To evaluate the efficacy of canakinumab, an anti-interleukin-1β antibody, in hospitalized COVID-19.This randomized, double-blind, placebo-controlled phase 3 trial was conducted at 39 hospitals Europe and United States. A total 454 pneumonia, hypoxia (not requiring invasive mechanical ventilation [IMV]), systemic hyperinflammation defined by increased blood concentrations C-reactive protein or ferritin were enrolled between...
Solid organ transplant recipients are considered at high risk for COVID-19 infection due to chronic immune suppression; little data currently exists on the manifestations and outcomes of in lung recipients. Here we report 8 cases identified patients with a history transplant. We describe clinical course disease as well preexisting characteristics these patients.
Most studies of solid organ transplant (SOT) recipients with COVID-19 focus on outcomes within one month illness onset. Delayed mortality in SOT hospitalized for has not been fully examined.
The Lung Allocation Score (LAS) prioritises lung transplantation candidates, balancing waitlist mortality and post-transplant survival. score groups sarcoidosis candidates based on mean pulmonary artery pressure: those with ≤30 mmHg (sarcoidosis A) are grouped COPD >30 D) idiopathic fibrosis (IPF). We hypothesise that have a higher than other within their LAS grouping.This is retrospective cohort study of consecutive from the Scientific Registry Transplant Recipients database May 2005 to...
A 58-year-old woman with stage 4 adenocarcinoma of the lung being treated pembrolizumab developed dyspnea, non-productive cough, and a right middle lobe infiltrate. Complete resolution infiltrate cessation pembrolizumab, initiation prednisone no antibiotic therapy suggested drug-associated toxicity as cause. While programmed death-1 (PD-1) inhibitors –pembrolizumab nivolumab – have been implicated cause diffuse or multifocal pulmonary infiltrates, current case represents, to our knowledge,...
Purpose of Review To review what is currently known about the pathogenesis, diagnosis, treatment, and prevention acute rejection (AR) in lung transplantation. Recent Findings Epigenomic transcriptomic methods are gaining traction as tools for earlier detection AR, which still remains primarily a histopathologic diagnosis. Summary Acute common cause early posttransplant graft dysfunction increases risk chronic rejection. Detection diagnosis AR based on histopathology, but noninvasive...
Physical health status defines an individual's ability to perform normal activities of daily living and is usually assessed in clinical settings by questionnaires and/or validated tests, e.g. timed walk tests. These measurements have relatively low information content are limited frequency. Wearable sensors, such as activity monitors, enable remote measurement parameters associated with physical but not been widely explored beyond step count. Here we report on results from a cohort 22...