Nitender Goyal
A5052642323- COVID-19 Clinical Research Studies
- Renal Transplantation Outcomes and Treatments
- Sepsis Diagnosis and Treatment
- Organ Donation and Transplantation
- Intensive Care Unit Cognitive Disorders
- Polyomavirus and related diseases
- Dialysis and Renal Disease Management
- Parvovirus B19 Infection Studies
- Neurological Complications and Syndromes
- Long-Term Effects of COVID-19
- Muscle and Compartmental Disorders
- Organ Transplantation Techniques and Outcomes
- COVID-19 and healthcare impacts
- Renal and Vascular Pathologies
- Respiratory Support and Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Full-Duplex Wireless Communications
- Venous Thromboembolism Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
- Poisoning and overdose treatments
- Transplantation: Methods and Outcomes
- Antenna Design and Analysis
- HIV/AIDS drug development and treatment
- Renal Diseases and Glomerulopathies
Alnylam Pharmaceuticals (United States)
2024-2025
Tufts Medical Center
2015-2024
Barts Health NHS Trust
2024
Northwestern University
2021
University of Wisconsin–Madison
2021
Tufts University
2018-2021
University Medical Center
2021
Saint Louis University
2018
St. Louis VA Medical Center
2018
<h3>Importance</h3> The US is currently an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, yet few national data are available on patient characteristics, treatment, and outcomes critical illness from COVID-19. <h3>Objectives</h3> To assess factors associated with death to examine interhospital variation in treatment for patients <h3>Design, Setting, Participants</h3> This multicenter cohort study assessed 2215 adults laboratory-confirmed COVID-19 who were admitted intensive...
Significance Statement Although AKI is an important sequela of coronavirus disease 2019 (COVID-19), data on treated with RRT (AKI-RRT) in patients COVID-19 are limited. In a multicenter cohort study 3099 critically ill adults admitted to intensive care units (ICUs) at 67 hospitals across the United States, one five developed AKI-RRT, 63% whom died during hospitalization. Among who survived hospital discharge, three remained dependent and six 60 days after ICU admission. The identified...
Hypercoagulability may be a key mechanism of death in patients with coronavirus disease 2019 (COVID-19).
Angiotensinogen is the most upstream precursor of renin-angiotensin-aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis.
To explore threats and opportunities to chart a path for safely navigating the rapid changes that generative artificial intelligence (AI) will bring clinical research, Duke Clinical Research Institute convened multidisciplinary think tank in January 2024. Leading experts from academia, industry, nonprofits, government agencies highlighted potential of AI automation documentation, strengthening participant community engagement, improvement trial accuracy efficiency. Challenges include...
Kidney dysfunction is not uncommon in patients with advanced heart failure. Simultaneous kidney and transplants (SKHTs) have gained acceptance as a treatment for end-stage failure severe dysfunction. United States saw rise of 650% SKHT from 2000 to 2019. Despite increasing number SKHT, the selection criteria remain poorly defined vary across transplant centers.We evaluated patient cardiac allograft survival alone (HTA) using Network Organ Sharing (UNOS) database. We then performed subgroup...
OBJECTIVES: Critically ill patients with coronavirus disease 2019 have variable mortality. Risk scores could improve care and be used for prognostic enrichment in trials. We aimed to compare machine learning algorithms develop a simple tool predicting 28-day mortality ICU 2019. DESIGN: This was an observational study of adult The primary outcome inhospital Machine models were derived using variables from the first 48 hours admission validated externally independent sites temporally more...
Most studies of solid organ transplant (SOT) recipients with COVID-19 focus on outcomes within one month illness onset. Delayed mortality in SOT hospitalized for has not been fully examined.
Transplant-associated thrombotic microangiopathy (TMA) in the post–organ transplantation setting occurs from a number of potential inciting factors, such as use calcineurin inhibitors, ischemic injury, infections, or antibody-mediated rejection leading to unchecked complement activation and end-organ damage. Delayed recognition this condition can result allograft loss. In case description, we describe first de novo TMA patient with polycystic kidney disease that occurred immediately after...
The COVID-19 Pandemic has been governed by various policies across the world, with corresponding public health measures varying in rigidity. Does this influence course of illness within each nation? This research presents an analysis policy approaches adopted United States, China, and India, to describe rigidity effects on case numbers mortality rates. We show that high is correlated lower mortality. Rigidity also influenced available resources country; for a resource-poor country like...
Background: Zilebesiran is an investigational subcutaneous (SC) RNA interference therapeutic targeting hepatic angiotensinogen synthesis. In the Phase 2 KARDIA-1 study (NCT04936035), changes in blood pressure (BP) were assessed with different zilebesiran dosing regimens as monotherapy patients mild-to-moderate hypertension, and clinically significant reductions ambulatory office systolic BP (SBP) observed throughout 6-month treatment period. this analysis, we report time-adjusted SBP, a...
Background Proteinuria is associated with worse allograft outcomes in kidney transplant recipients (KTRs) and treatment strategies are limited. We examined the of calcineurin inhibitor (CNI) to belatacept conversion proteinuric KTRs. Methods In a pilot phase II single-arm multicenter prospective trial, we recruited adult KTRs &gt;6 months post-kidney transplantation an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73m 2 proteinuria &gt;1 g/day. Patients were converted from...