A5058861911- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Cardiac Structural Anomalies and Repair
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Organ Transplantation Techniques and Outcomes
- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- Nonmelanoma Skin Cancer Studies
- Organ and Tissue Transplantation Research
- Medication Adherence and Compliance
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiac tumors and thrombi
- Health and Wellbeing Research
- Parathyroid Disorders and Treatments
- Clinical Laboratory Practices and Quality Control
- Neurological and metabolic disorders
- Cardiac Ischemia and Reperfusion
- Urinary Bladder and Prostate Research
- Advanced Proteomics Techniques and Applications
- Hematopoietic Stem Cell Transplantation
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Genomics and Rare Diseases
Kaiser Permanente
2005-2024
Kaiser Permanente Santa Clara Medical Center
2009-2022
Stanford University
2006-2012
Colorado Permanente Medical Group
2012
Kaiser Permanente San Jose Medical Center
2006-2008
Stanford Medicine
2006
In a prospective cohort study of heart transplant recipients, sequencing-based quantification donor-derived DNA in plasma recipients noninvasively diagnosed rejection.
Sirolimus was introduced in de novo immunosuppression at Stanford University view of its favorable effects on reduced rejection and cardiac allograft vasculopathy. After an apparent increase the incidence post-surgical wound complications as well symptomatic pleural pericardial effusions, we reverted to a mycophenolate mofetil (MMF)-based regimen. This retrospective study compared outcome heart transplant recipients sirolimus (48 patients) with those MMF (46 immunosuppressive The any...
Background. Anticytomegalovirus (CMV) prophylaxis prevents the acute disease but its impact on subclinical infection and allograft outcome is unknown. We sought to determine whether CMV administered for three months after heart transplant would improve patient outcomes. Methods. This prospective cohort study of 66 recipients compared aggressive (n=21, hyperimmune globulin [CMVIG] plus four weeks intravenous ganciclovir followed by two valganciclovir); with standard (n=45, weeks). Prophylaxis...
The concentrations of total glycerol, unesterified and glycerol deriving from triglycerides (triacylglycerols) were measured in 468 fresh human sera unselected outpatients a municipal hospital. distribution mode free was log-normal; that neither normal nor log-normal. A weak but statistically approved correlation between these variables demonstrated. comparison triglyceride corrected for with those based on shows that, the determination, analysis substraction 0.11 mmol/liter resulting value...
Microvascular dysfunction is emerging as a strong predictor of outcome in heart transplant recipients. At this time, the determinants and consequences early microvascular are not well established. The objective study was to determine risk factors functional correlates associated with recipients.Sixty-three recipients who had coronary physiology assessment, right catheterization, echocardiography performed at time their first annual evaluation were included study. assessed using recently...
The ongoing shortage of donors for cardiac transplantation has led to a trend toward acceptance donor hearts with some structural abnormalities including left ventricular hypertrophy. To evaluate the outcome in recipients increased wall thickness (LVWT), we retrospectively analyzed data 157 and respective from January 2001 December 2004. There were 47 heart LVWT >or=1.2 cm, which constituted study group 110 normal < 1.2 cm that formed control group. At 3 +/- 1.5 years, recipient survival was...
Most studies of solid organ transplant (SOT) recipients with COVID-19 focus on outcomes within one month illness onset. Delayed mortality in SOT hospitalized for has not been fully examined.
Background. Cardiac allograft vasculopathy (CAV) is a major cause of death after heart transplantation (HT). The reduced bioavailability endothelium-derived nitric oxide may play role in endothelial vasodilator dysfunction and thus the structural changes characterizing CAV. A potential contributor to pathobiology asymmetric dimethylarginine (ADMA), an endogenous synthase inhibitor. It was hypothesized that ADMA concentrations influence CAV progression during first postoperative year....
Objective: The purpose of this study was to evaluate the effects depression and anxiety before heart transplant on all-cause mortality after in a Northern California cohort. Methods: A total 130 adult patients with transplants enrolled at Kaiser Permanente between June 2005 December 2013 were included retrospective chart review. Preoperative anxiety, evidenced by diagnoses, other risk factors for investigated. Statistical methods Kaplan–Meier survival analysis Cox proportional hazard...
The US health care industry has broadly adopted performance and quality measures that are extracted from electronic records connected to payment incentives hope improve declining life expectancy status reduce costs. While the development of a measurement infrastructure based on record data was an important first step in addressing outcomes, these metrics, reflecting average across diverse populations, do not adequately adjust for population demographic differences, social determinants...
A new method for differential blood counts using pre-stained slides showed it to be suitable routine use. To differentiate white cells the same experience was needed as conventional stainings. Normal and abnormal pictures can reliably distinguished. The particular advantage of is in simple preparation smear avoiding need time-consuming staining.
A fully enzymatic triglyceride determination utilizing hydrolysis with a lipase-esterase mixture and subsequent glycerol determination, has been adapted for use in continuous flow 12-channel-analyzer. The method is linear up to 7.9 mmol/l (700 mg/100 ml). analytical precision the concentration range of 1.5 5.4 (133 478 ml) characterized by relative standard deviations 0.8 4.8%. In lower measuring at concentrations around 0.7 (62 mean deviation 7.2% found 1140 measurements under routine...