A5033482985- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Viral Infections and Immunology Research
- Pluripotent Stem Cells Research
- Cardiac Fibrosis and Remodeling
- Renal Transplantation Outcomes and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Fuel Cells and Related Materials
- Cardiac Imaging and Diagnostics
- Cardiac tumors and thrombi
- ECG Monitoring and Analysis
- Congenital Heart Disease Studies
- Pancreatic function and diabetes
- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
Ljubljana University Medical Centre
2015-2024
University of Ljubljana
2000-2023
University Medical Center
2005-2022
Columbia University Irving Medical Center
2021
NewYork–Presbyterian Hospital
2021
Yale University
2021
New York Hospital Queens
2021
Orion Corporation (Finland)
2020
Stanford University
2011-2019
Palo Alto University
2008-2019
CD34+ transplantation in dilated cardiomyopathy was associated with short-term improvement left ventricular ejection fraction and exercise tolerance.We investigated long-term effects of intracoronary cell the relationship between intramyocardial homing clinical response.Of 110 patients, 55 were randomized to receive stem (SC group) received no therapy (controls). In SC group, cells mobilized by granulocyte colony-stimulating factor collected via apheresis. Patients underwent myocardial...
The role of QTc interval prolongation in heart failure remains poorly defined. To better understand it, we analyzed the duration patients with high B-type natriuretic peptide (BNP) levels and combined prognostic impact prolonged elevated BNP.QTc intervals were measured 241 who had BNP >400 pg/mL. QT was determined by averaging 3 consecutive beats through leads II V4 on a standard 12-lead ECG corrected using Bazett formula. (>440 ms) 122 (51%) normal 119 (49%). these 2 groups not...
Background— In an open-label blinded study, we compared intracoronary and transendocardial CD34 + cell transplantation in patients with nonischemic dilated cardiomyopathy. Methods Results— Of the 40 cardiomyopathy, 20 were randomized to receive injection received delivery. both groups, cells mobilized by filgrastim, collected via apheresis, labeled technetium-99m radioisotope for single-photon emission computed tomographic imaging. group, injected intracoronarily artery supplying segments of...
Background: To describe the baseline characteristics of patients with heart failure and preserved left ventricular ejection fraction enrolled in PARAGON-HF trial (Prospective Comparison Angiotensin Receptor Neprilysin Inhibitor With Blocker Global Outcomes HFpEF) comparing sacubitril/valsartan to valsartan reducing morbidity mortality. Methods Results: We report key demographic, clinical, laboratory findings, therapies, 4822 randomized PARAGON-HF, grouped by factors that influence criteria...
Frailty is an increasingly common problem, and frail patients are less likely to receive new pharmacologic therapies because the risk-benefit profile perceived be favorable than in nonfrail patients.This study investigated efficacy of sacubitril/valsartan according frailty status 4,796 with heart failure preserved ejection fraction randomized PARAGON-HF (Prospective Comparison ARNI With ARB Global Outcomes Heart Failure Preserved Ejection Fraction) trial.Frailty was measured by using...
The aim of the SCIENCE trial was to investigate whether a single treatment with direct intramyocardial injections adipose tissue-derived mesenchymal stromal cells (CSCC_ASCs) safe and improved cardiac function in patients chronic ischaemic heart failure reduced ejection fraction (HFrEF).The study European multicentre, double-blind, placebo-controlled phase II using allogeneic CSCC_ASCs from healthy donors or placebo (2:1 randomization). Main inclusion criteria were New York Heart Association...
Inotropes aim at increasing cardiac output by enhancing contractility. They constitute the third pharmacological pillar in treatment of patients with decompensated heart failure, other two being diuretics and vasodilators. Three classes parenterally administered inotropes are currently indicated for (i) beta adrenergic agonists, including dopamine dobutamine also catecholamines epinephrine norepinephrine, (ii) phosphodiesterase III inhibitor milrinone (iii) calcium sensitizer levosimendan....
Resting conventional 12-lead ECG has low sensitivity for detection of coronary artery disease (CAD) and left ventricular hypertrophy (LVH) positive predictive value (PPV) prediction systolic dysfunction (LVSD). We hypothesized that a ~5-min resting advanced test ("A-ECG") combined results from both the could more accurately screen these conditions than strictly ECG. Results nearly every parameter known literature to have diagnostic or were first retrospectively evaluated in 418 healthy...
Aims The objective of this study was to determine the factors independently associated with septal curvature in patients pulmonary arterial hypertension ( PAH ). Methods Eighty‐five consecutive who had an echocardiogram and a right heart catheterization within 24 hours each others were included study. Septal assessed at mid‐papillary level using eccentricity index EI Marked early systolic anterior motion defined as change > 0.2 between end‐diastole systole. Inter‐ventricular mechanical...
BackgroundThe intravenous inodilator levosimendan was developed for the treatment of patients with acutely decompensated heart failure. In last decade scientific and clinical interest has arisen its repetitive or intermittent use in advanced chronic, but not necessarily decompensated, Recent studies have suggested long-lasting favourable effects when administered repetitively, terms haemodynamic parameters, neurohormonal inflammatory markers, outcomes. The existing data, however, requires...
Background— We investigated the effects of transendocardial CD34 + cell transplantation in patients with ischemic cardiomyopathy. Methods and Results— In a prospective crossover study, we enrolled 33 cardiomyopathy New York Heart Association class III left ventricular ejection fraction <40%. phase 1, were treated medical therapy for 6 months. Thereafter, all underwent transplantation. Peripheral blood cells mobilized by granulocyte colony stimulating factor, collected via apheresis,...
Abstract Hospitalization for acute heart failure (HF) is associated with a substantial morbidity burden and healthcare costs an increased mortality risk. However, few if any major medical innovations have been witnessed in this area recent times. Levosimendan first‐in‐class calcium sensitizer potassium channel opener indicated the management of HF. Experience several clinical studies has that administration intravenous levosimendan intermittent cycles may reduce hospitalization rates...
The LeoDOR trial explored the efficacy and safety of intermittent levosimendan therapy in vulnerable phase following a hospitalization for acute heart failure (HF).In this prospective multicentre, double-blind, two-armed trial, patients with advanced HF were randomized 2:1 at end an index to or matching placebo 12 weeks. All had left ventricular ejection fraction (LVEF) ≤30% during hospitalization. Levosimendan was administered according centre preference either as 6 h infusion rate 0.2...