A5020826579- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Metabolomics and Mass Spectrometry Studies
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Adrenal Hormones and Disorders
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
- Non-Invasive Vital Sign Monitoring
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- S100 Proteins and Annexins
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Immune Response and Inflammation
- Acute Kidney Injury Research
- Ultrasound in Clinical Applications
- Heart rate and cardiovascular health
- Dialysis and Renal Disease Management
Université Libre de Bruxelles
2016-2025
Centre Hospitalier Universitaire de Saint-Pierre
2023-2024
Erasmus Hospital
2014-2022
Inotropes aim at increasing cardiac output by enhancing contractility. They constitute the third pharmacological pillar in treatment of patients with decompensated heart failure, other two being diuretics and vasodilators. Three classes parenterally administered inotropes are currently indicated for (i) beta adrenergic agonists, including dopamine dobutamine also catecholamines epinephrine norepinephrine, (ii) phosphodiesterase III inhibitor milrinone (iii) calcium sensitizer levosimendan....
Abstract Background Alterations in the renin–angiotensin system have been implicated pathophysiology of septic shock. In particular, angiotensin 1–7 (Ang-(1–7)), an anti-inflammatory heptapeptide, has hypothesized to beneficial effects. The aim present study was test effects Ang-(1–7) infusion on development and severity Methods This randomized, open-label, controlled performed 14 anesthetized mechanically ventilated sheep. Immediately after sepsis induction by bacterial peritonitis, animals...
Uncontrolled proteolysis contributes to cell injury and organ dysfunction in animal models of circulatory shock. We investigated humans the relationship between septic shock, proteolysis, outcome.Intensive care patients with shock (n=29) or sepsis (n=6) non-hospitalised subjects (n=9) were recruited as part prospective observational trial 'ShockOmics' (ClinicalTrials.gov Identifier NCT02141607). A mass spectrometry-based approach was used analyse plasma peptidomes origin circulating peptides...
Background: Histones are released during cellular damage and cell death. In addition to their intrinsic toxicity, posttranslational modifications (PTMs) in histones impact the sepsis response. Histone PTMs cardiogenic shock (CS) remain unclear. We explored temporal dynamics of nucleosomes histone 3 (H3) PTM patterns septic (SS) CS whether neutralization by administration sodium-β-O-methyl cellobioside sulfate (mCBS) could influence H3 SS. Methods: Two experiments were conducted. first, SS...
Abstract Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone system in critically ill patients. Emerging data suggest that this vital homeostatic system, which plays crucial role maintaining systemic and renal hemodynamics during stressful conditions, is altered septic shock, ultimately leading to impaired angiotensin II—angiotensin II type 1 receptor signaling. Indeed, available evidence from both experimental models human studies indicates alterations...
Acute inflammation and sepsis are known to induce changes in vascular properties, leading increased arterial stiffness; at the same time, autonomic nervous system (ANS) also affects properties by modulating smooth muscle tone, it is widely reported that septic shock severely impair ANS activity. Currently, clinical guidelines mainly concerned resuscitate patients from hypotension, hypovolemia, hypoperfusion; however, if current resuscitation maneuvers have a beneficial effect on...
Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on myocardium remain unclear. The aim study was to compare angiotensin and norepinephrine cardiac function myocardial oxygen consumption, inflammation injury experimental shock.This randomized, open-label, controlled performed 20 anesthetized mechanically ventilated pigs. Septic shock induced by fecal peritonitis 16 animals, four pigs served as shams. Resuscitation with fluids, antimicrobial...
Abstract Background Dipeptidyl peptidase 3 (DPP3) is a ubiquitous cytosolic enzyme released into the bloodstream after tissue injury, that can degrade angiotensin II. High concentrations of circulating DPP3 (cDPP3) have been associated with worse outcomes during sepsis. The aim this study was to assess effect Procizumab (PCZ), monoclonal antibody neutralizes cDPP3, in an experimental model septic shock. Methods In randomized, open-label, controlled study, 16 anesthetized and mechanically...
Circulatory shock is a life-threatening disease that accounts for around one-third of all admissions to intensive care units (ICU). It requires immediate treatment, which why the development tools planning therapeutic interventions required deal with in critical environment. In this study, ShockOmics European project original database used extract attributes capable predicting mortality due ICU. Missing data imputation techniques and machine learning models were used, followed by feature...
Abstract Background Septic shock (SS) and cardiogenic (CS) are two types of circulatory with a different etiology. Several studies have described the molecular alterations in SS patients, whereas factors involved CS been poorly investigated. We aimed to assess whole blood using septic patients without (SC) as controls, transcriptomic modifications that occur over 1 week after ICU admission common shock. Methods performed RNA sequencing 21 SS, 11 CS, 5 SC. In samples were collected within 16...
Altered iron metabolism plays a central role in the development of anaemia critically ill patients but time course status septic and non-septic has not been well defined.Prospective study 34-bed medico-surgical ICU. The complete blood count, iron, ferritin, transferrin, transferrin receptor concentrations, saturation C-reactive protein (CRP) concentrations were measured on days 1, 3 5 ICU stay 95 consecutive (33 with sepsis 62 without).Despite an identical count day had significantly lower...
The ShockOmics study (ClinicalTrials.gov identifier NCT02141607) is a multicenter prospective observational trial aimed at identifying new biomarkers of acute heart failure in circulatory shock, by means multiscale analysis blood samples and hemodynamic data from subjects with shock. Ninety septic shock cardiogenic patients will be recruited three intensive care units (ICU) (Hôpital Erasme, Université Libre de Bruxelles, Belgium; Hospital Universitari Mutua Terrassa, Spain; Hôpitaux...
Septic shock is a medical emergency and one of the main causes mortality in critically ill patients. Given pathophysiological complexity sepsis spectrum progression clinical settings, animal models become essential tools to improve patient care understand key mechanisms that may remain masked from heterogeneity practice. Our aim was verify whether metabolic constellations we previously reported for septic patients appear also our swine model as systemic markers early disturbances energy...