A5046462982- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Parasitic Infections and Diagnostics
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Immunotherapy and Immune Responses
- Heat shock proteins research
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- interferon and immune responses
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Allergic Rhinitis and Sensitization
- Metabolism, Diabetes, and Cancer
- Natural product bioactivities and synthesis
- Cytomegalovirus and herpesvirus research
Cancer Research Institute Ghent
2016-2025
VIB-UGent Center for Medical Biotechnology
2016-2025
Ghent University
2015-2024
Vlaams Instituut voor Biotechnologie
1998-2024
Allegheny Health Network
2022
Weatherford College
2022
VIB-UGent Center for Inflammation Research
2020
Ghent University Hospital
2009-2017
Memorial Sloan Kettering Cancer Center
2013
Chang Gung Memorial Hospital
2012
Interleukin-6 (IL-6) is a pleiotropic cytokine, whose plasma levels are elevated in inflammatory diseases such as atherosclerosis. We have previously reported that peroxisome proliferator-activated receptor alpha (PPARalpha) ligands (fibrates) lower concentrations of IL-6 patients with atherosclerosis and inhibit IL-1-stimulated secretion by human aortic smooth muscle cells (SMC). Here, we show explants isolated from PPARalpha-null mice display an exacerbated response to stimuli,...
Interleukin-6 (IL-6) is a pleiotropic cytokine, which involved in inflammatory and immune responses, acute phase reactions, hematopoiesis. In the mouse fibrosarcoma cell line L929, nuclear factor (NF)-κB plays crucial role IL-6 gene expression mediated by tumor necrosis (TNF). The levels of activated do not, however, correlate with variations transcription; therefore, other factors and/or regulatory mechanisms presumably modulate mRNA production. Upon analysis various deletion point-mutated...
Glucocorticoids exert multiple anti-inflammatory activities, one of which is the inhibition transcription dependent on nuclear factor (NF)-κB. It has been suggested that effect dexamethasone (DEX), a glucocorticoid analog, attributed to an increased production inhibitory IκB molecule, in turn would bind and remove activated, DNA-bound NF-κB complexes cell nucleus. Upon investigating DEX-mediated repression interleukin-6 expression induced by tumor necrosis factor, DEX treatment was found act...
Expression of the pleiotropic cytokine interleukin (IL)-6 can be stimulated by proinflammatory tumor necrosis factor (TNF) and microbial alkaloid staurosporine (STS). In this report, transcriptional mechanisms were thoroughly investigated. Whereas transcription factors binding to activator protein-1-, cAMP-responsive element-, CAAT enhancer-binding protein-responsive sequences are necessary for gene activation STS, nuclear (NF)-kappaB alone is responsible sufficient inducibility TNF, which...
Glucocorticoids (GCs) are used to combat inflammatory diseases. Their beneficial effect relies mainly on the inhibition of NF-κB- and/or AP-1-driven proinflammatory gene expression. Previously, we have shown that GCs repress tumor necrosis factor-induced IL-6 expression by an NF-κB-dependent nuclear mechanism without changing DNA-binding capacity NF-κB or levels cytoplasmic inhibitor (IκB-α). In present work, investigate GC repression different natural recombinant NF-κB-driven reporter...
The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating properties GR are mainly associated with undesirable side effects, its negative interference activity transcription factors, such as NF-κB, greatly contributes to antiinflammatory immune-suppressive capacities. In present study, we found that Compound A (CpdA), a...
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and strongly associated with central obesity, dyslipidemia, insulin resistance. According to the multiple-hit model of NAFLD pathogenesis, lipid accumulation drives nonalcoholic steatohepatitis (NASH) initiation by triggering oxidative stress, lipotoxicity, subsequent activation hepatic inflammatory responses that may progress, in predisposed individuals, fibrosis cirrhosis. While there an unmet therapeutical need for NASH...