A5042093927- Cytokine Signaling Pathways and Interactions
- Estrogen and related hormone effects
- NF-κB Signaling Pathways
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- Heat shock proteins research
- Eating Disorders and Behaviors
- Stress Responses and Cortisol
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Allergic Rhinitis and Sensitization
- Signaling Pathways in Disease
- Inflammatory mediators and NSAID effects
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- Obsessive-Compulsive Spectrum Disorders
- Neuroblastoma Research and Treatments
- Multiple Myeloma Research and Treatments
- Youth Substance Use and School Attendance
- Protein Tyrosine Phosphatases
- Pathogenesis and Treatment of Hiccups
- Lymphoma Diagnosis and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Hippo pathway signaling and YAP/TAZ
University College Odisee
2017-2023
University College Ghent
2017-2021
Cancer Research Institute Ghent
2013-2020
Ghent University
2009-2020
Queen Mary University of London
2019
Helmholtz Zentrum München
2016-2019
University of Turin
2019
Ablynx (Belgium)
2019
Argenx (Belgium)
2019
Ghent University Hospital
2012-2017
The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating properties GR are mainly associated with undesirable side effects, its negative interference activity transcription factors, such as NF-κB, greatly contributes to antiinflammatory immune-suppressive capacities. In present study, we found that Compound A (CpdA), a...
Neoangiogenesis is a critical component of chronic inflammatory disorders. Inhibition angiogenesis an effective treatment in animal models inflammation, but has not been tested experimental colitis.To investigate the effect ATN-161, anti-angiogenic compound, on course murine colitis.Interleukin 10-deficient (IL10(-/-)) mice and wild-type were kept ultra-barrier facilities (UBF) or conventional housing, used for conditions. Dextran sodium sulphate (DSS)-treated as model acute colitis. Mice...
Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based transcriptome analysis was applied epithelial-like MCF-7 and triple negative mesenchymal MDA-MB-231 breast cells exposed to concentrations WA which can be detected systemically vivo experiments. Whereas demonstrated attenuation multiple...
Glucocorticoids (GCs) block inflammation via interference of the liganded glucocorticoid receptor (GR) with activity pro-inflammatory transcription factors NF-κB and AP-1, a mechanism known as transrepression. This is believed to involve GR monomers. Here, we explored how monomer-favoring Compound A (CpdA) affects AP-1 activation activity. Our results demonstrate that non-steroidal CpdA, unlike classic steroidal GCs, blocks NF-κB- but not AP-1-driven gene expression. CpdA rather sustains...
Abstract The glucocorticoid receptor (GR) is a crucial drug target in multiple myeloma as its activation with glucocorticoids effectively triggers cell death. However, high-dose are also associated deleterious side effects, novel approaches urgently needed to improve GR action myeloma. Here, we reveal functional crosstalk between and the mineralocorticoid (MR) that plays role improved killing. We show agonist dexamethasone (Dex) downregulates MR levels GR-dependent way cells. Co-treatment of...
Summary Background Besides allergens, pollen release bioactive, low molecular weight compounds that modulate and stimulate allergic reactions. Clinical relevance of these substances has not been investigated to date. Objective To elucidate the effect a non‐allergenic, factors from aqueous birch extracts (Bet‐ APE < 3 kDa) on human immune response in vivo . Methods Birch grass individuals underwent skin prick testing with allergen alone, plus Bet‐ kDa, or pre‐identified candidate fraction....
Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, can repress NF-κB-mediated gene expression. However, the monomeric A-activated is unable to trigger response element-regulated The heat shock potently activates factor 1 (HSF1), upregulates Hsp70, a known chaperone, and also modulates various aspects of inflammation. We found that selective modulator similar cellular effects in A549 lung epithelial cells. With regard...
Angiogenesis is important in cancer progression and can be influenced by tumor-associated myofibroblasts. We addressed the hypothesis that glucocorticoids indirectly affect angiogenesis altering release of pro-angiogenic factors from colon cancer-derived Our study shows reduced prostanoids, urokinase-type plasminogen activator (uPA) angiopoietin-like protein-2 (ANGPTL2) levels, but increased angiogenin (ANG) supernatant human CT5.3hTERT Conditioned medium solvent- (CMS) dexamethasone...
Respiratory exposure to marine phycotoxins is of increasing concern. Inhalation sea spray aerosols (SSAs), during harmful Karenia brevis and Ostreopsis ovata blooms induces respiratory distress among others. The biogenics hypothesis, however, suggests that regular airborne natural products health promoting via a downregulation the mechanistic target rapamycin (mTOR) pathway. Until now, little scientific evidence supported this hypothesis. current explorative in vitro study investigated both...