A5053451031- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- Indoor Air Quality and Microbial Exposure
- Contact Dermatitis and Allergies
- COVID-19 epidemiological studies
- Air Quality and Health Impacts
- Pediatric health and respiratory diseases
- Cytomegalovirus and herpesvirus research
- Lichen and fungal ecology
- Plant Reproductive Biology
- Ecology and Vegetation Dynamics Studies
- Climate Change and Health Impacts
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Animal Ecology and Behavior Studies
- Biomedical and Chemical Research
- IL-33, ST2, and ILC Pathways
- Plant and animal studies
- Olfactory and Sensory Function Studies
- Cardiac Ischemia and Reperfusion
University of Augsburg
2015-2025
Universidad Autónoma de Madrid
2025
Helmholtz Zentrum München
2015-2024
Technical University of Munich
2012-2021
CK-CARE
2013-2019
German Center for Lung Research
2013-2015
Klinikum rechts der Isar
2014
Hôpital Max Fourestier
2011
Zero to Three
2009
Ludwig-Maximilians-Universität München
2003-2006
Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. IFN-λs (also termed IL-28/29) are potent immunomodulatory and antiviral cytokines. We demonstrate that poly IC injection vivo induces large amounts of IFN-λ, which depended on hematopoietic cells the presence TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), IRF8 but not MyD88 (myeloid differentiation 88), Rig-like...
Significance Coexposure to airborne pollen enhances susceptibility respiratory viral infections, regardless of the allergy status. We hypothesized this could be also true for SARS-CoV-2 infections. To investigate this, we tested relationships between infection rates and concentrations, along with humidity, temperature, population density, lockdown effects. Our unique dataset derives from 130 sites in 31 countries across five continents. found that pollen, sometimes synergy humidity...
Background Evidence is compelling for a positive correlation between climate change, urbanisation and prevalence of allergic sensitisation diseases. The reason this association not clear to date. Some data point pro-allergenic effect anthropogenic factors on susceptible individuals. Objectives To evaluate the impact change pollen allergenicity. Methods Catkins were sampled from birch trees different sites across greater area Munich, isolated an index, NO2 ozone exposure determined. estimate...
Hundreds of plant species release their pollen into the air every year during early spring. During that period, allergic as well non-allergic patients frequently present to doctors with severe respiratory tract infections. Our objective was therefore assess whether may interfere antiviral immunity.We combined data from real-life human exposure cohorts, a mouse model and cell culture test our hypothesis.Pollen significantly diminished interferon-λ pro-inflammatory chemokine responses airway...
Pollen allergies have been rapidly increasing over the last decades. Many allergenic proteins and non-allergenic adjuvant compounds of pollen are involved in plant defense against environmental or microbial stress. The first aim this study was to analyze compare colonizing microbes on pollen. second investigate detectable correlations between microbiota parameters air pollution allergenicity. To reach these aims, bacterial fungal DNA isolated from samples timothy grass (Phleum pratense, n =...
Abstract IL-12p70 is a key cytokine for the induction of Th1 immune responses. production in myeloid cells thought to be strictly controlled by T cell help. In this work we demonstrate that primary human monocytes can produce absence We show express TLR4 and TLR8 but lack TLR3 TLR7 even after preincubation with type I IFN. Simultaneous stimulation induced monocytes. peripheral blood dendritic required combined TLR7/8 ligands together or ligands. presence cell-derived IL-4, not IFN-γ, was...
Common ragweed has been spreading as a neophyte in Europe. Elevated CO2 levels, hallmark of global climate change, have shown to increase pollen production, but their effects on allergenicity remain be elucidated.Ragweed was grown climate-controlled chambers under normal (380 ppm, control) or elevated (700 based RCP4.5 scenario) levels. Aqueous extracts (RWE) from control- -pollen were administered vivo mouse model for allergic disease (daily 3-11 days, n = 5) and employed human vitro...
Over 100 million people worldwide suffer from birch pollen allergy. Bet v 1 has been identified as the major allergen. However, molecular mechanisms of allergic sensitization, including roles and other components extract, remain incompletely understood. Here, we examined how known pollen-derived molecules influence endolysosomal processing 1, thereby shaping its allergenicity.We analyzed biochemical immunological interaction ligands with 1. We then investigated proteolytic by endosomal...
Abstract The EAACI Guidelines on the impact of short‐term exposure to outdoor pollutants asthma‐related outcomes provide recommendations for prevention, patient care and mitigation in a framework supporting rational decisions healthcare professionals patients individualize improve asthma management policymakers regulators as an evidence‐informed reference help setting legally binding standards goals air quality at international, national local levels. Guideline was developed using GRADE...
Objectives: Our study sought to elucidate the role of oxidative stress for shedding tumor necrosis factor-α (TNF-α) and activating TNF-α-converting enzyme (TACE). Background: TNF-α, a central inflammatory cytokine, is discussed as one mediators reperfusion injury. Shedding membrane-bound pro-TNF-α thought be largely due Methods: Release TNF-α TACE dependency were studied in isolated rat hearts human mast cell line HMC-1. Results: In reperfused hearts, interstitial release occurred two phases...
In a humid milieu such as mucosal surfaces, pollen grains do not only release allergens but also proinflammatory and immunomodulatory lipids, termed pollen-associated lipid mediators. Among these, the E(1)-phytoprostanes (PPE(1)) were identified to modulate dendritic cell (DC) function: PPE(1) inhibit DC's capacity produce IL-12 enhance DC mediated T(H)2 polarization of naive T cells. The mechanism(s) by which act on remained elusive. We thus analyzed candidate signaling elements their role...
ABSTRACT The EAACI Guidelines used the GRADE approach to evaluate impact of major indoor air pollutants (dampness and mould, cleaning agents, volatile organic compounds pesticides) on risk new‐onset asthma asthma‐related outcomes. guideline also acknowledges synergies among other components exposome (allergens, viruses, endotoxins). Very low certainty evidence was found for association between exposure increased worsening. Only mould there moderate asthma. Due quality evidence, conditional...
Abstract The immune response of atopic individuals against allergens is characterized by increased levels Th2 cytokines and chemokines. However, the way in which cytokine/chemokine profile matched to type invading allergen, why these profiles sometimes derail lead disease, not well understood. We recently demonstrated that pollen modulates dendritic cell (DC) function a results an enhanced capacity initiate responses vitro. Here, we examined effects aqueous birch extracts (Bet.-APE) on...
Abstract Pollen allergy is characterized by a T H 2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather plethora of protein and non-protein substances. We demonstrated that pollen liberate lipids with chemical functional similarities leukotriens prostaglandins - the associated lipid mediators (PALMs). To date, two main groups PALMs have been characterized: The immunostimulatory activating innate cells such as...
Summary Background Besides allergens, pollen release bioactive, low molecular weight compounds that modulate and stimulate allergic reactions. Clinical relevance of these substances has not been investigated to date. Objective To elucidate the effect a non‐allergenic, factors from aqueous birch extracts (Bet‐ APE < 3 kDa) on human immune response in vivo . Methods Birch grass individuals underwent skin prick testing with allergen alone, plus Bet‐ kDa, or pre‐identified candidate fraction....