A5090246147- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Sperm and Testicular Function
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Reproductive Biology and Fertility
- Immune Cell Function and Interaction
- Genital Health and Disease
- Mast cells and histamine
- Pediatric health and respiratory diseases
- Antimicrobial Peptides and Activities
- Ocular Surface and Contact Lens
- Urticaria and Related Conditions
- Immunodeficiency and Autoimmune Disorders
- Drug-Induced Adverse Reactions
- Ovarian function and disorders
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Psoriasis: Treatment and Pathogenesis
- Bee Products Chemical Analysis
- Salivary Gland Tumors Diagnosis and Treatment
University Hospital Bonn
2013-2023
University of Bonn
2012-2022
Jessa Hospital
2021
CK-CARE
2016
Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie
2013
Medical University of Vienna
2004
Background: Sublingual immunotherapy (SLIT) represents an alternative to subcutaneous immunotherapy. While antigen‐presenting cells such as Langerhans (LCs) are thought contribute the effectiveness of SLIT, mast (MCs) most likely account for adverse reactions sublingual edema. As little is known about LCs and MCs within oral cavity, we investigated their distribution in search mucosal sites with highest lowest density. Methods: Biopsies were taken simultaneously from human vestibulum, bucca,...
Summary Background House dust mites (HDMs) represent significant indoor allergen sources for patients with atopic dermatitis (AD). Subcutaneous allergen‐specific immunotherapy (SCIT) has been shown to be successful in allergic rhinitis and mild asthma might an attractive therapeutic option the long‐term treatment of HDM sensitizations AD patients. However, only a few studies have conducted on effectiveness SCIT AD, resulting controversial clinical results. Data immunological changes induced...
To analyse antigen-presenting cells (APCs), such as dendritic (DCs), macrophages (Mo) or B depending on the regional site of chronic periodontitis (CP), and to investigate their relation Th17 cells.Biopsies from oral mucosa well coronal bottom regions CP were analysed by immunhistochemistry, immunofluorescence, flow cytometry real-time PCR.A predominance CD68(+) Mo-like CD20(+) strong infiltration was observed in region lesions, while CD1a(+) DCs only detected regions, where low....
Infection and inflammation of the male reproductive tract are thought to be a primary aetiological factor infertility. Furthermore, several studies suggest that T lymphocytes critically involved as regulator in pathogenesis infertility under these conditions induce autoimmune orchitis. In this context autoimmunity recently described helper (Th) 17 subset has been suggested play an essential role so aim study was investigate expression characteristics Th17 cells well presence inducing antigen...
The objective of this study was to investigate the impact human beta-defensins (hBDs) on oral squamous cell carcinoma (OSCC) proliferation and hBD expression in vitro. BHY-OSCC lines were stimulated with hBD-1, -2, -3. Proliferation BHY cells ascertained hBD-mRNA evaluated by real-time PCR. decreased 25% response hBD-1 stimulation but increased after hBD-2 HBD-1 enhanced hBD-3 expression, whereas HBD-2 early expression. HBD-3 HBDs profoundly OSCC Therefore, might function as a tumor...
Mucosal dendritic cells (DC) play a crucial role in tolerance induction as seen mucosal immunotherapy of atopic diseases. Nevertheless little is known about the phenotypical differences oral and nasal DC (nmDC). Recently, we could show that myeloid CD1a(+) (omDC) differ from their skin counterparts especially by expression high affinity receptor for immunoglobulin E (IgE; FcepsilonRI). However, pattern FcepsilonRI characteristics nmDC have not been elucidated detailed yet.We performed...
Most local oral vaccine strategies use the sublingual region for drug application. Only little is known about cytokine micromilieu, nature of T cell subtypes and expression target structures adjuvants at different mucosal regions (OMR). However, targeting optimal OMR might ensure highest efficiency uptake lowest risk adverse effects.Expression TGF-β1, IL10 as well Th1, Th2 Th17 cytokines transcription factors was investigated skin by quantitative real-time PCR, immunohistochemistry or flow...
Allergen-specific venom immunotherapy (VIT) represents the only rational-based option to treat allergic sensitizations against bee and wasp venom. So far, there is not much knowledge about early induction of protective tolerogenic pathways during VIT.To identify earliest markers for mechanisms reactions in peripheral blood build-up phase VIT.PBMC monocytes were isolated, serum samples taken before a five day from 65 hymenoptera patients. Expression level was analyzed on mRNA protein level....
Purpose of this study was to investigate whether human β-defensins (hBDs) affect maturation and proliferation osteoblast-like MG63 cells in vitro. Osteoblast-like were stimulated with hBD-1, -2, -3 under control conditions hBD-2 during experimental inflammation (induced by interleukin-1β, tumor necrosis factor-α, toll-like receptor-2 -4 agonists). Expression different osteogenic markers hBDs analyzed real-time PCR, immunohistochemistry, enzyme-linked immunosorbent assay. In addition,...