A5079129479- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Immune Response and Inflammation
- Oral Health Pathology and Treatment
- Bone and Dental Protein Studies
- dental development and anomalies
- Salivary Gland Disorders and Functions
- Oral and gingival health research
- Osteoarthritis Treatment and Mechanisms
- Dental Health and Care Utilization
- Adipokines, Inflammation, and Metabolic Diseases
- Dental Trauma and Treatments
- Antimicrobial Peptides and Activities
- Dental Research and COVID-19
- Bone Metabolism and Diseases
- Orthodontics and Dentofacial Orthopedics
- Protease and Inhibitor Mechanisms
- Diabetes and associated disorders
- NF-κB Signaling Pathways
- Wound Healing and Treatments
- Regulation of Appetite and Obesity
- S100 Proteins and Annexins
- Dental Implant Techniques and Outcomes
- Tendon Structure and Treatment
- Autophagy in Disease and Therapy
Johannes Gutenberg University Mainz
2018-2025
University Medical Center of the Johannes Gutenberg University Mainz
2018-2025
Poliklinik für Zahnerhaltung und Parodontologie
2011-2022
Saveetha University
2021
University Medical Centre Mannheim
2020
The University of Sydney
2017-2018
University of Bonn
2007-2017
University Hospital Bonn
2011-2017
The Ohio State University
2004-2006
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2003
A multicentre survey was designed to evaluate the impact of COVID-19 outbreak on dental practice worldwide, estimate related symptoms/signs, work attitudes and behaviour routine use protective measures Personal Protective Equipment (PPE).A global using a standardized questionnaire with research groups from 36 countries designed. The developed pretested during April 2020 contained three domains: 1) data; 2) positive rate symptoms/signs presumably coronavirus; 3) Working conditions PPE adopted...
The mechanisms by which chondrocytes convert biomechanical signals into intracellular biochemical events are not well understood. In this study, we sought to determine the of magnitude-dependent actions mechanical signals.Chondrocytes isolated from rabbit articular cartilage were grown on flexible membranes. Cells subjected cyclic tensile strain (CTS) various magnitudes in presence or absence interleukin-1beta (IL-1beta), was used as a proinflammatory signal for designated time intervals....
To analyse antigen-presenting cells (APCs), such as dendritic (DCs), macrophages (Mo) or B depending on the regional site of chronic periodontitis (CP), and to investigate their relation Th17 cells.Biopsies from oral mucosa well coronal bottom regions CP were analysed by immunhistochemistry, immunofluorescence, flow cytometry real-time PCR.A predominance CD68(+) Mo-like CD20(+) strong infiltration was observed in region lesions, while CD1a(+) DCs only detected regions, where low....
The Centres for Disease Control and Prevention the World Health Organization have developed preparedness prevention checklists healthcare professionals regarding containment of COVID-19. aim present protocol is to evaluate impact COVID-19 outbreak among dentists in different countries where various prevalence epidemic has been reported. Several research groups around world were contacted by central management team. online anonymous survey will be conducted on a convenience sample working...
(1) This study investigated the whitening effect, cytotoxicity and enamel surface alterations induced by different over-the-counter (OTC) bleaching agents in comparison to hydrogen peroxide. (2) Human teeth (n = 60) were randomly assigned into 6 groups 10), stained with coffee solution for 7 d, followed a period of d either placebo, bromelain, sodium bicarbonate, chlorite, PAP or Color measurements performed spectrophotometer. Scanning electron micrographs (SEM) taken assess structure....
Background Periodontitis is an inflammatory disease caused by pathogenic microorganisms, such as Porphyromonas gingivalis, and characterized the destruction of periodontium. Obese individuals have increased risk for periodontitis show decreased serum levels adiponectin. This in-vitro study was established to examine whether adiponectin modulates critical effects lipopolysaccharide (LPS) from P. gingivalis on oral epithelial cells (OECs). Methodology/Principal Findings The presence its...
Abstract Aim This study aimed to evaluate the contribution of biomechanical loading inflammation‐induced tissue destruction. Materials and Methods A total 144 adult Holtzman rats were randomly assigned into four experimental groups: control (C), ligature‐induced periodontal disease (P), orthodontic movement ( OM ), combination group OMP ). On days 1, 3, 7, 15, following baseline, nine animals from each killed. Bone volume fraction BVF ) bone mineral density BMD measured using micro‐computed...
Abstract The aim of this study was to analyse the effect cold atmospheric plasma (CAP) on human osteoblast-like cells in vitro. Additionally, underlying intracellular mechanisms were be studied. Human (MG63) exposed CAP for 60 s. effects key molecules essential wound healing response studied using real-time PCR, ELISA and immunocytochemistry. For studying signalling pathways, MAP kinase MEK 1/2 blocked. Cell viability analysed by an XTT assay with EVE automated cell counter. migration...
During orthodontic tooth movement (OTM) to therapeutically correct the position of misaligned teeth, thus improving oral health and quality life, fibroblasts, macrophages, other immune cells within periodontal ligament (PDL), which connects a its surrounding bone, are exposed compressive tensile strain. While it is known that PDL fibroblasts critically involved in biological regulation OTM by mechanotransductively triggered release cytokines, unclear whether macrophages also react pressure...
The aim of this in vitro and vivo study was to investigate the interaction periodontitis orthodontic tooth movement on interleukin (IL)-6 C-X-C motif chemokine 2 (CXCL2).The effect and/or (OTM) alveolar bone gingival IL-6 CXCL2 expressions studied rats by histology RT-PCR, respectively. animals were assigned four groups (control, periodontitis, OTM, combination OTM). levels also human biopsies from periodontally healthy subjects RT-PCR immunohistochemistry. Additionally, synthesis response...