A5047698443- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Streptococcal Infections and Treatments
- Endodontics and Root Canal Treatments
- Salivary Gland Disorders and Functions
- Periodontal Regeneration and Treatments
- Oral and gingival health research
- Dental Radiography and Imaging
- Dental Implant Techniques and Outcomes
- Dental Health and Care Utilization
- Bacterial biofilms and quorum sensing
- Dental materials and restorations
- HIV/AIDS oral health manifestations
- Laser Applications in Dentistry and Medicine
- Immune Response and Inflammation
- Infective Endocarditis Diagnosis and Management
- Dental Research and COVID-19
- Rheumatoid Arthritis Research and Therapies
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal and Maternal Infections
- Photodynamic Therapy Research Studies
- Proteoglycans and glycosaminoglycans research
- Regulation of Appetite and Obesity
- Antimicrobial Peptides and Activities
- Antimicrobial Resistance in Staphylococcus
University of Bern
2016-2025
Leipzig University
2020
Clinical Research Management
2016
Regenerative Medicine Institute
2016
Atatürk University
2014
Nagasaki University
2014
Universidade de São Paulo
2014
University Hospital of Bern
2013
Jena University Hospital
1999-2010
Friedrich Schiller University Jena
1998-2009
To investigate protein citrullination by the periodontal pathogen Porphyromonas gingivalis as a potential mechanism for breaking tolerance to citrullinated proteins in rheumatoid arthritis (RA).The expression of endogenous was analyzed immunoblotting cell extracts from P and 10 other oral bacteria. gingivalis-knockout strains lacking bacterial peptidylarginine deiminases (PADs) or gingipains were created assess role these enzymes citrullination. Citrullination human fibrinogen α-enolase...
Abstract Objective: To monitor clinical, microbiological and host‐derived alterations occurring around teeth titanium implants during the development of experimental gingivitis/mucositis their respective healing sequence in humans. Material methods: Fifteen subjects with healthy or treated periodontal conditions restored dental underwent an 3‐week period undisturbed plaque accumulation mandible. Subsequently, a optimal control was instituted. At Days 0, 7, 14, 21, 28, 35 42, presence/absence...
Abstract Objective The objective of the study is to compare clinical, microbiological and host‐derived effects in non‐surgical treatment initial peri‐implantitis with either adjunctive local drug delivery ( LDD ) or photodynamic therapy PDT after 12 months. Materials Methods Forty subjects peri‐implantitis, that is, pocket probing depths PPD 4–6 mm bleeding on (BoP) radiographic bone loss ≤2 mm, were randomly assigned two groups. All implants mechanically debrided titanium curettes a...
Abstract Objective To compare the adjunctive clinical effects in non‐surgical treatment of peri‐implantitis with either local drug delivery ( LDD ) or photodynamic therapy PDT ). Material and methods Forty subjects initial peri‐implantitis, i.e. pocket probing depths PPD 4–6 mm concomitant bleeding on BoP marginal bone loss ranging from 0.5 to 2 between reconstruction pre‐screening appointment were randomly assigned two groups. All implants underwent mechanical debridement titanium curettes,...
During periodontitis, an innate immune response to bacterial challenge is primarily mediated by neutrophils. We compared neutrophilic content and the level of neutrophil-derived antimicrobial peptides in gingival crevicular fluid (GCF) two clinical forms severe periodontitis.GCF was collected from 14 patients with aggressive 17 chronic nine healthy subjects. Samples were analyzed for periodontopathogen load using real-time polymerase chain reactions. The amounts myeloperoxidase...
The analysis of samplings from periodontal pockets is important in the diagnosis and therapy periodontitis. In this study, three different sampling techniques were compared to determine whether one method yielded samples suitable for reproducible simultaneous determination bacterial load, cytokines, neutrophil elastase, arginine-specific gingipains (Rgps). Rgps are an virulence factor Porphyromonas gingivalis, exact concentration which gingival crevicular fluid (GCF) has not been...
The objective of this study is to investigate the outcomes following non-surgical therapy peri-implantitis (PI) with or without adjunctive diode laser application.A double-blinded randomized controlled clinical trial was carried out in 25 subjects implants diagnosed PI. Following curettage granulation tissue, test (T) were treated application a for 90 s (settings: 810 nm, 2.5 W, 50 Hz, 10 ms), while at control (C) non-activated applied. entire treatment procedure performed days 0 (i.e.,...
The aim of this study was to determine the effect a probiotic milk drink on gingival health and development experimental gingivitis.Fifty volunteer students took part in parallel-designed non-blinded study. test group drank once day; control did not receive any product drink. After 8 weeks, individual mechanical plaque interrupted for 96 h. Papilla bleeding index, interproximal Turesky index (PI) were recorded at baseline, after weeks again h later. At same time points, crevicular fluid had...
Periodontitis is an inflammatory disease of the supporting structures teeth caused by, among other pathogens, Prevotella intermedia. Many strains P. intermedia are resistant to killing by human complement system, which present at up 70% serum concentration in gingival crevicular fluid. Incubation with recombinant cysteine protease (interpain A) resulted a drastic decrease bactericidal activity serum. Furthermore, clinical strain 59 expressing interpain A was more serum-resistant than another...
Background: The study is designed to determine the effect on clinical variables, subgingival bacteria, and local immune response brought about by application of hyaluronan‐containing gels in early wound healing after scaling root planing (SRP). Methods: In this randomized study, data from 34 individuals with chronic periodontitis were evaluated full‐mouth SRP. test group (n = 17), hyaluronan two molecular weights additionally applied during first 2 weeks control 17) was treated SRP only....
While oral rinses used for cosmetic purposes only do not necessarily have to be antiseptic, antimicrobial activity is required medical indications, including and periodontal surgery. So the question arises-is of associated with any destructive changes in cell viability vitro? To answer this question, we examined twelve respect their cytotoxic activity. Antimicrobial was screened against five bacterial strains using disc diffusion. Cytotoxicity determined by mitochondrial reductase primary...
Tannerella forsythia is a poorly studied pathogen despite being one of the main causes periodontitis, which an inflammatory disease supporting structures teeth. We found that recognized by all complement pathways, T. resistant to killing human complement, present at up 70% serum concentration in gingival crevicular fluid. Incubation with karilysin, metalloproteinase forsythia, resulted decrease bactericidal activity serum. strains expressing karilysin higher levels were more than...
Neutrophil-derived networks of DNA-composed extracellular fibers covered with antimicrobial molecules, referred to as neutrophil traps (NETs), are recognized a physiological microbicidal mechanism innate immunity. The formation NETs is also classified model cell death called NETosis. Despite intensive research on the in response pathogens, role specific bacteria-derived virulence factors this process, although postulated, still poorly understood. aim our study was determine gingipains,...
To determine the microbiota at implants and adjacent teeth 10 years after placement of with a sandblasted acid-etched surface.Plaque samples obtained from deepest sites 504 493 were analyzed for certain bacterial species associated periodontitis, staphylococci, aerobic gram-negative rods, yeasts using nucleic acid-based methods.Species known to be periodontitis detectable 6.2-78.4% implants. Significantly higher counts in comparison assessed Tannerella forsythia, Parvimonas micra,...
Background: Recent studies suggest a link between periodontitis and Alzheimer’s disease (AD). Objective: Verification of the presence periodontal pathogens intrathecal generation pathogen-specific antibodies in 20 patients with AD other forms dementia (DEM-noAD). Methods: Clinical indices were recorded. Cerebrospinal fluid (CSF) was analyzed for total tau protein (T-tau) amyloid-β (Aβ 1-42 ). In serum CSF, antibody levels against Porphyromonas gingivalis, Aggregatibacter...