A5081677181- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Reproductive tract infections research
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Musculoskeletal synovial abnormalities and treatments
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Reproductive System and Pregnancy
- Microbial infections and disease research
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Oral Health Pathology and Treatment
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Hepatitis B Virus Studies
- Iron Metabolism and Disorders
- Dental materials and restorations
- SARS-CoV-2 and COVID-19 Research
University Hospital of Bern
2016-2025
University of Bern
2007-2025
University of Bari Aldo Moro
2024
Medical University of Vienna
2008-2023
SCQM Foundation
2023
University of Otago
2023
ENT and Allergy
2022
Jena University Hospital
2021
University of Lübeck
2011-2020
University Hospital Schleswig-Holstein
2011-2020
B-cell-depleting therapies increase the risk of morbidity and mortality due to COVID-19. Evidence-based SARS-CoV-2 vaccination strategies for patients on are scarce. We aimed investigate humoral cell-mediated immune responses mRNA-based vaccines in receiving CD20-targeted agents autoimmune disease, malignancy, or transplantation.The RituxiVac study was an investigator-initiated, single-centre, open-label done at Bern University Hospital (Bern, Switzerland). Patients with a treatment history...
Abstract Objective Patients with rheumatoid arthritis (RA) in whom the response to anti–tumor necrosis factor (anti‐TNF) therapy is inadequate have several therapeutic options, such as switching an alternative anti‐TNF agent or initiating B cell–depleting rituximab (RTX). Although both options been proven effective trials, no head‐to‐head comparisons are available. The aim of this study was compare effectiveness RTX that management patients RA who had therapy. Methods This prospective cohort...
Objective. To examine whether the G-to-A polymorphism at position −308 in promoter of tumour necrosis factor-α (TNFα) gene influences therapeutic response to TNFα-blockers patients with rheumatoid arthritis (RA), psoriatic (PsA) and ankylosing spondylitis (AS). Methods . A total 54 RA, 10 PsA 22 AS were genotyped by polymerase chain reaction for TNFα polymorphism. They treated infliximab ( n = 63), adalimumab 10) or etanercept 13). Clinical was assessed after 24 weeks Disease Activity Score...
Background: Patients with rheumatoid arthritis (RA) an inadequate response to TNF antagonists (aTNFs) may switch alternative aTNF or start treatment from a different class of drugs, such as rituximab (RTX). It remains unclear in which clinical settings these therapeutic strategies offer most benefit. Objective: To analyse the effectiveness RTX versus aTNFs on RA disease activity subgroups patients. Methods: A prospective cohort study patients who discontinued at least one and subsequently...
<h3>Objectives</h3> Non-steroidal anti-inflammatory drugs (NSAIDs) may cause kidney damage. This study assessed the impact of prolonged NSAID exposure on renal function in a large rheumatoid arthritis (RA) patient cohort. <h3>Methods</h3> Renal was prospectively followed between 1996 and 2007 4101 RA patients with multilevel mixed models for longitudinal data over mean period 3.2 years. Among 2739 'NSAID users' were 1290 treated cyclooxygenase type 2 selective NSAIDs, while 1362 subjects...
To analyse the association between female hormonal factors and development of systemic autoimmunity associated with RA in women at increased risk for RA, namely first-degree relatives patients (RA-FDRs).In an ongoing cohort study RA-FDRs, we analysed all available ACPA status. The primary outcome was positivity. predictors interest were factors, such as oral contraceptives, breastfeeding, post-menopausal status, early period total number ovulatory years.A 768 RA-FDRs analysed, which 42 (5%)...
Few studies have investigated the impact of obesity on response to tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA). The aim our study was investigate different body mass index (BMI) categories TNFi a large cohort axSpA.Patients axSpA within Swiss Clinical Quality Management (SCQM) program were included current if they fulfilled Assessment Spondyloarthritis International Society (ASAS) criteria for axSpA, started first after recruitment, and had...
To investigate whether the transient reduction in rheumatology services imposed by virus containment measures during COVID-19 pandemic was associated with disease worsening axial spondyloarthritis (axSpA), rheumatoid arthritis (RA) or psoriatic (PsA).Patient-reported activity assessed face-to-face visits and/or via a smartphone application were compared between three periods of each 2 months duration (before, and after COVID-19-wave) from January to June 2020 666 patients axSpA, RA PsA Swiss...
Comedication with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) during treatment tumour necrosis factor inhibitors (TNFi) is extensively used in psoriatic arthritis (PsA), although the additive benefit remains unclear. We aimed to compare outcomes patients PsA treated TNFi and csDMARD comedication versus monotherapy.Patients from 13 European countries who initiated a first 2006-2017 were included. Country-specific comparisons of 1 year retention performed by status,...
Abstract Objective To evaluate the reliability and validity of a novel ultrasound (US) imaging method to measure metacarpophalangeal (MCP) proximal interphalangeal (PIP) finger joint cartilage. Methods We examined 48 patients with rheumatoid arthritis (RA), 18 osteoarthritis (OA), 24 unclassified joints, 34 healthy volunteers. The cartilage layer MCP PIP joints for fingers 2–5 was bilaterally visualized from posterior view, in ∼90° flexion. Cartilage thickness measured integrated tools on...
Abstract Systemic lupus erythematosus (SLE) is a chronic disease which can affect any organ, and the impact of condition will each person differently. There are few qualitative studies including experiences both women men with diagnosis SLE corresponding to American College Rheumatology (ACR) criteria where negative positive impacts have been presented. Purpose The aim was describe how patients established experience their illness in everyday life, aspects. Method Four focus group interviews...
Anaemia in rheumatoid arthritis (RA) is prototypical of the chronic disease type and often neglected clinical practice. We studied anaemia relation to activity, medications radiographic progression.Data were collected between 1996 2007 over a mean follow-up 2.2 years. was defined according WHO (♀ haemoglobin<12 g/dl, ♂: haemoglobin<13 g/dl), or alternative criteria. prevalence parameters pharmacological therapy. Radiographic progression analysed 9731 radiograph sets from 2681 patients crude...
Objective To compare effectiveness of treatment with secukinumab (SEC) that alternative tumour necrosis factor inhibitors (TNFis) in patients axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis. Methods Patients diagnosed as having axSpA the Swiss Clinical Quality Management cohort were included if they had initiated SEC (n=106) an TNFi (n=284) experiencing failure. Drug retention was investigated matching weights propensity score (PS) analyses and multiple adjusted Cox...
There is a lack of real-life studies on interleukin-17 (IL-17) inhibition in psoriatic arthritis (PsA). We assessed 6- and 12-month effectiveness (i.e., retention, remission, low disease activity [LDA], response rates) the IL-17 inhibitor secukinumab PsA patients overall across 1) number prior biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs), 2) years since diagnosis, 3) European registries.Thirteen quality registries rheumatology participating Spondyloarthritis...
Abstract Objectives JAK Inhibitors (JAKi) are recommended DMARDs for patients with moderate-to-severe RA who failed first-line therapy methotrexate. There is a lack of data allowing an evidence-based choice subsequent DMARD had discontinued JAKi treatment. We aimed to compare the effectiveness TNF inhibitor (TNFi) vs other mode action (OMA) biologic (bDMARD) in were previously treated JAKi. Methods treatment within Swiss registry SCQM included this observational prospective cohort study. The...
<b>Objectives:</b> Regulatory T cells (Tregs) exert their anti-inflammatory activity predominantly by cell contact-dependent mechanisms. A study was undertaken to investigate the regulatory capacity of autologous peripheral blood Tregs in contact with synovial tissue cultures, and evaluate presence blood, fluid patients rheumatoid arthritis (RA). <b>Methods:</b> 44 RA 5 osteoarthritis were included study. The frequency interferon (IFN)γ-secreting quantified CD3-depleted cultures co-cultured...
Paired sera from 60 consecutive patients with acute salpingitis, confirmed by laparoscopy, were examined for serum antibodies to Chlamydia trachomatis, Mycoplasma hominis, and Neisseria gonorrhoeae. By a microimmunofluorescence (MIF) test IgM or IgG C trachomatis both present in 80% of the patients9 indirect haemagglutination (IHA) tests M hominis N gonorrhoeae pilar antigens 40% 18% respectively. In control group 50 pregnant women same three organisms occurred 8%, 6%. Evidence current...