A5023985133- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
- Eosinophilic Esophagitis
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Dermatology and Skin Diseases
- Pharmacological Effects of Natural Compounds
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- Celiac Disease Research and Management
- Systemic Sclerosis and Related Diseases
- Immunotherapy and Immune Responses
- Bacterial Identification and Susceptibility Testing
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Spondyloarthritis Studies and Treatments
- Adrenal Hormones and Disorders
University Hospital of Geneva
2014-2025
University of Geneva
2008-2024
Center for Rheumatology
2020-2024
Geneva College
2010-2024
Centre for Inflammation Research
2024
Hôpital Beau-Séjour
2019-2023
Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence Prevotella spp. in group individuals at increased risk for RA, but prior to development disease.In an ongoing cohort study first-degree relatives (FDRs) patients we identified 'FDR controls', asymptomatic without autoantibodies, pre-clinical RA stages, who had either developed anticitrullinated peptide antibodies or rheumatoid factor...
Abstract Objective Interleukin‐33 (IL‐33; or, IL‐1F11) was recently identified as the ligand of IL‐1 family receptor T1/ST2. The aim this study to examine IL‐33 production in human and mouse joints investigate role T1/ST2 experimental arthritis. Methods expression examined synovial tissue, rheumatoid arthritis (RA) fibroblasts, arthritic joints. Mice with collagen‐induced (CIA) were treated blocking anti‐ST2 antibody or control beginning at onset disease. Arthritis severity assessed by...
The new interleukin (IL)-1 family cytokine IL-33 is synthesized as a 30-kDa precursor. Like pro-IL-1β, human pro-IL-33 was reported to be cleaved by caspase-1 generate an 18-kDa fragment, which sufficient activate signaling the receptor T1/ST2. However, proposed cleavage site poorly conserved between species. In addition, it not clear whether of occurs in vivo and whether, for IL-1β, this prerequisite secretion bioactivity. study, we further investigated mouse assessed potential bioactivity...
Abstract Background Calprotectin (S100A8/S100A9 protein) is known as a damage-associated molecular pattern (DAMP) protein and reflects mainly neutrophil activation. Serum calprotectin levels might be good alternative to acute-phase biomarker in inflammatory rheumatic diseases. The aim of this study investigate the association serum with disease activity severity rheumatoid arthritis (RA), axial spondyloarthritis (axSpA), psoriatic (PsA). Methods was measured patients RA, axSpA, PsA from...
To analyse the association between female hormonal factors and development of systemic autoimmunity associated with RA in women at increased risk for RA, namely first-degree relatives patients (RA-FDRs).In an ongoing cohort study RA-FDRs, we analysed all available ACPA status. The primary outcome was positivity. predictors interest were factors, such as oral contraceptives, breastfeeding, post-menopausal status, early period total number ovulatory years.A 768 RA-FDRs analysed, which 42 (5%)...
Psoriatic arthritis (PsA) has a strong genetic component, and the identification of risk factors could help identify ~30% psoriasis patients at high developing PsA. Our objectives were to pathways that differentiate PsA from cutaneous-only (PsC) evaluate performance prediction models.Genome-wide meta-analyses conducted separately for 5,065 with 21,286 healthy controls 4,340 6,431 PsC. The heritability was calculated as single-nucleotide polymorphism (SNP)-based estimate (h2SNP ) biologic PsC...
Abstract Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to not fully explained variation at robustly risk loci. To move towards saturation map susceptibility we meta-analysed 18 GWAS comprising 36,466 cases and 458,078 controls 109 distinct loci, 45 that been previously reported. These include variants loci in which...
The proinflammatory activities of IL-1 are tightly controlled at different levels. IL-1R2 acts as a decoy receptor and has been shown to regulate the biological effects in vitro vivo. However, little is known about its natural expression mouse physiologic pathologic conditions. In this study, we examined mRNA protein isolated cells tissues response stimulatory Data obtained using ex vivo CD11b(+)Ly6G(+) peripheral blood vitro-differentiated BMG indicated that neutrophils major source...
Interleukin (IL)-36 refers to three related IL-1 family cytokines, IL-36α, IL-36β, and IL-36γ, that bind the IL-36 receptor (IL-36R). exerts proinflammatory effects in skin lung stimulates T cell responses. In present study, we examined expression function of IL-36R its ligands experimental arthritis. Collagen-induced arthritis (CIA), antigen-induced (AIA), K/BxN serum transfer-induced were induced according standard protocols. Messenger RNA levels for joints mice with CIA determined by...
GenBank entries for mouse Il33 reveal the existence of two transcripts, Il33a and Il33b, with different 5'UTRs but coding same protein. We investigated expression these transcripts in organs cell types basal inflammatory conditions. Il33b mRNAs start noncoding first exons, transcribed from promoter regions, which both contain a consensus TATA-like sequence. Constitutive mRNA was detected stomach, lung, spleen, brain, whereas observed only stomach. Expression increased after systemic LPS...
The balance between interleukin-1 (IL-1) and its specific inhibitor, the IL-1 receptor antagonist (IL-1Ra), plays a major role in development of arthritis. purpose this study was to investigate IL-1Ra produced specifically by myeloid cells control collagen-induced arthritis (CIA) using cell-specific IL-1Ra-deficient mice (IL-1Ra(DeltaM)).IL-1Ra(DeltaM) were generated loxP/Cre recombinase system. CIA induced IL-1Ra(DeltaM) littermate single immunization with bovine type II collagen (CII)...
Interleukin (IL)-33 is a cytokine of the IL-1 family, which signals through ST2 receptor. Previous work suggested implication IL-33/ST2 axis in pathogenesis human and mouse arthritis. Here, we directly investigated role endogenous IL-33 K/BxN serum transfer-induced arthritis by using knockout (KO) mice. Arthritis was induced injection complete or purified IgG. Disease severity monitored clinical histological scoring. transfer pronounced with similar incidence KO wild-type (WT) In contrast,...
Introduction The diagnosis of Rheumatoid Arthritis (RA) is based on a combined approach that includes serological markers such as Factor (RF) and Anti-Citrullinated Peptide/Protein Antibodies (ACPA). goal this study was to evaluate the clinical performance several RF ACPA immunoassays for RA, well diagnostic value combinatory with these markers. Methods cohort included 1655 patients from Swiss Clinical Quality Management (SCQM) registry sera 968 RA 687 disease controls, including Axial...
Purpose Rheumatoid arthritis (RA) is an insidious autoimmune disease, with immunological onset years before diagnosis. Early interventions in preclinical stages could prevent or minimise the progression towards irreversible joint damage. The SCREEN-RA cohort (Evaluation of a SCREENing strategy for Arthritis) aims to characterise identify environmental risk factors, and discover validate novel biomarkers predictive RA development. Participants includes at-risk population RA, namely...
To investigate the association between severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) infection and subsequent development of autoimmunity or pre-clinical manifestations associated with rheumatoid arthritis (RA) in at risk population.This is a nested study within prospective cohort first-degree relatives RA patients (RA-FDR). Participants are tested for RA-associated autoantibodies (anti-citrullinated peptide antibodies (ACPA)/rheumatoid factor (RF)) clinical signs...
Faecal Prevotellaceae, and other microbes, have been associated with rheumatoid arthritis (RA) preclinical RA. We performed a quantitative microbiome profiling study in stages of First-degree relatives patients RA (RA-FDRs) from the SCREEN-RA cohort were categorised into four groups: controls, healthy asymptomatic RA-FDRs; high genetic risk, RA-FDRs two copies shared epitope; autoimmunity, RA-associated autoimmunity; symptomatic, clinically suspect arthralgias or untreated new-onset...
Objective To validate the prognostic accuracy of anti-apolipoprotein A-1 (AAA1) IgG for incident major adverse cardiovascular (CV) events (MACE) in rheumatoid arthritis (RA) and study their associations with lipid paradox at a multicentric scale. Method Baseline AAA1 IgG, profile, atherogenic indexes, cardiac biomarkers were measured on serum 1,472 patients RA included prospective Swiss Clinical Quality Management registry median follow-up duration 4.4 years. MACE was primary endpoint...
Abstract Objectives The objective of this study was to analyse the predictive value anti-carbamylated protein (anti-CarP) and anti-peptidyl-arginine deiminase type-3 (anti-PAD3) antibodies, alone or in combination with RF ACPA, identify patients at high risk developing severe RA outcomes. Methods Patients within Swiss Clinical Quality Management registry a biobank sample were tested for RF, anti-CarP, anti-PAD3 antibodies. We examined association each autoantibody DAS28, HAQ radiographic...