Michael Duckworth
A5084513261- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- Eosinophilic Esophagitis
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- Acne and Rosacea Treatments and Effects
- Synthesis and biological activity
- melanin and skin pigmentation
- IL-33, ST2, and ILC Pathways
- Spondyloarthritis Studies and Treatments
- Helicobacter pylori-related gastroenterology studies
- Biosimilars and Bioanalytical Methods
- Prostate Cancer Treatment and Research
- Immune Cell Function and Interaction
- Colorectal Cancer Screening and Detection
- COVID-19 and healthcare impacts
- Hair Growth and Disorders
- Cytokine Signaling Pathways and Interactions
- Autoimmune and Inflammatory Disorders Research
- Prostate Cancer Diagnosis and Treatment
- Gastroesophageal reflux and treatments
King's College London
2014-2025
Guy's and St Thomas' NHS Foundation Trust
2015-2019
National Health Service
2019
St John's Hospital
2018
BC Cancer Agency
2002
Leamington Spa Hospital
2002
University of Baltimore
2002
Kyoto Pharmaceutical University
1998
Biologics have transformed management of inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by circulating drug levels has been proposed. We aimed to determine the real-world clinical utility therapeutic monitoring in psoriasis. Within a multicenter (n = 60) prospective observational cohort, 544 psoriasis patients were included who receiving adalimumab monotherapy had at least one serum sample Psoriasis Area Severity Index (PASI) score available within...
Psoriatic arthritis (PsA) has a strong genetic component, and the identification of risk factors could help identify ~30% psoriasis patients at high developing PsA. Our objectives were to pathways that differentiate PsA from cutaneous-only (PsC) evaluate performance prediction models.Genome-wide meta-analyses conducted separately for 5,065 with 21,286 healthy controls 4,340 6,431 PsC. The heritability was calculated as single-nucleotide polymorphism (SNP)-based estimate (h2SNP ) biologic PsC...
Abstract Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to not fully explained variation at robustly risk loci. To move towards saturation map susceptibility we meta-analysed 18 GWAS comprising 36,466 cases and 458,078 controls 109 distinct loci, 45 that been previously reported. These include variants loci in which...
High-cost biologic therapies have transformed the management of immune-mediated inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by measurement circulating drug levels has been shown to be effective in various settings. However, limited evidence exists for this approach with interleukin 12 23 inhibitor ustekinumab.To evaluate clinical utility therapeutic monitoring ustekinumab patients psoriasis.A prospective observational cohort 491 adults psoriasis was...
BackgroundFew studies have explored the immunology and genetic risk of paradoxical eczema occurring as an adverse event biologic therapy in patients with psoriasis.ObjectivesWe sought to describe systemic inflammatory signature using proteomics explore whether this is genetically mediated.MethodsThis study used Olink Target 96 Inflammation panel on 256 serum samples from 71 psoriasis eczema, 75 controls identify differentially expressed proteins enriched gene sets. Case 1 or more time points...
Advanced liver fibrosis is a precursor to cirrhosis, leading cause of mortality. People with severe psoriasis are at risk for disease, but our understanding advanced in individuals limited.To describe the prevalence and evaluate clinical factors associated people psoriasis.The Co-morbidities Severe Psoriasis study, prospective observational cohort study large center serving London Southeast England, was conducted from October 18, 2012, April 2, 2015; 400 adults (Psoriasis Area Severity Index...
The identification of robust endotypes-disease subgroups clinical relevance-is fundamental to stratified medicine. We hypothesized that HLA-C∗06:02 status, the major genetic determinant psoriasis, defines a psoriasis endotype relevance. Using two United Kingdom-based cross-sectional datasets-an observational severe-psoriasis study (Biomarkers Systemic Treatment Outcomes in Psoriasis; n = 3,767) and large population-based bioresource (UK Biobank, including 5,519 individuals with psoriasis)-we...
Targeted biologic therapies can elicit an undesirable host immune response characterized by the development of antidrug antibodies (ADA), important cause treatment failure. The most widely used across immune-mediated diseases is adalimumab, a tumor necrosis factor inhibitor. This study aimed to identify genetic variants that contribute ADA against thereby influencing In patients with psoriasis on their first course in whom serum had been evaluated 6-36 months after starting treatment, we...
Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation drug exposure. Real‐world psoriasis data were used develop a pharmacokinetic/pharmacodynamic (PK/PD) model the first‐line therapeutic antibody ustekinumab. The impact of differing dosing strategies on was explored. Data collected from UK prospective multicenter observational cohort (491 patients ustekinumab monotherapy, levels, and anti‐drug measurements 797 serum samples,...
Abstract As a visual-based specialty, dermatology has the opportunity to use artificial intelligence (AI) aid diagnosis and guide precision management of skin diseases. To employ effective safe AI, algorithms should be trained validated on data sets that are representative patient demographics in clinical practice. In our recent systematic review AI image analysis studies inflammatory conditions, ethnicity Fitzpatrick type were reported only four (6%) 10 (16%) 64 included studies,...
Dupilumab is prescribed in one dosage across adult atopic dermatitis patients. Differences drug exposure may explain variation treatment response.Investigating the clinical relevance of dupilumab serum concentration real-world practice.In two centers (Netherlands, UK), adults treated with for were evaluated effectiveness and safety pretreatment at 2, 12, 24, 48 weeks; trough samples analyzed corresponding time points.In 149 patients, median levels during follow-up ranged from 57.4 to 72.4...