A5065943846- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune Bullous Skin Diseases
- Personality Disorders and Psychopathology
- Empathy and Medical Education
- Body Image and Dysmorphia Studies
- Cutaneous lymphoproliferative disorders research
- Endometriosis Research and Treatment
- Complementary and Alternative Medicine Studies
- Patient-Provider Communication in Healthcare
- Asthma and respiratory diseases
- Mast cells and histamine
- Drug-Induced Adverse Reactions
- Psychosomatic Disorders and Their Treatments
- Pregnancy and Medication Impact
- Cancer-related Molecular Pathways
- Pharmacovigilance and Adverse Drug Reactions
- Vascular Tumors and Angiosarcomas
- Skin Diseases and Diabetes
- Skin and Cellular Biology Research
- Oral Health Pathology and Treatment
- DNA Repair Mechanisms
- Mental Health and Psychiatry
- Urticaria and Related Conditions
Imperial College London
2025
The Royal Free Hospital
2004-2023
University College London
2004-2023
National Health Service
2023
Royal Free London NHS Foundation Trust
2013-2023
Queen Mary University of London
2011
University of London
2006
Royal Victoria Infirmary
1997-2003
Kilimanjaro Christian Medical Centre
2002
Newcastle University
1999-2002
The role of ingrained cognitive and emotional patterns (schemas) in patients with psoriasis eczema has not previously been investigated. High levels psychiatric morbidity psychological distress observed these populations suggest the presence maladaptive schemas therefore a possible target for future successful intervention.To investigate early (EMS) to explore their links distress.A sample 185 adults (psoriasis n = 55, atopic 54, chronic disease control 23, normal 53) completed validated,...
Psoriasis is a common, long-term skin condition associated with high levels of psychological distress and considerable life impact. The impact psoriasis, beyond the skin, often not recognised under-treated. This paper explores relationship between psoriasis including reference to 'brain–skin access'. discussed pharmacological interventions which affect are reviewed. Evidence from peer-reviewed journals controlled trials inform text. has profound on mental health well-being under-recognised...
<h3>Importance</h3> Therapies that reduce psoriasis symptoms may improve work productivity. <h3>Objective</h3> To assess the effect of ixekizumab therapy on productivity, measured by Work Productivity and Activity Impairment–Psoriasis (WPAI-PSO). <h3>Design, Setting, Participants</h3> Three multicenter, randomized double-blind phase 3 trials conducted during following periods: December 2011 through August 2014 (UNCOVER-1), May 2012 April 2015 (UNCOVER-2), July (UNCOVER-3). Adult outpatients...
To determine the prevalence of skin disease in a rural Tanzanian community and to investigate health-seeking behavior this community.The study was 3 parts: (1) 120 heads households were interviewed factors that influence families' behavior; (2) 800 members these families examined for evidence disease; (3) focus group discussion held with influential get broader view behavior.A village southwestern area Tanzania: Individuals their own homes.A total 34.7% villagers had one or more diseases,...
ABSTRACT This paper examines the prevalence and comorbidity of complex post‐traumatic stress disorder (CPTSD) borderline personality (BPD) among individuals with probable disorder, using baseline data from Structured Psychological Support clinical trial. The characteristics functioning participants are summarised compared between those meeting criteria for BPD, CPTSD, both or neither condition. Among 292 participants, 97% reported significant trauma exposure, over half met CPTSD. Those CPTSD...
To investigate whether the observational skills of doctors and nurses can be improved by arts-based training.We carried out a cluster design, controlled trial involving 42 general practitioners 26 primary care in 12 practices London. Six were allocated to intervention arm 6 control arm. The group received 90 minutes training. practical training management psoriasis. Before after this, participants asked describe 3 dermatological photographs. Descriptions scored blindly against predetermined...
People with psoriasis report high levels of undermanaged distress. This is compounded by the problem that some patients find it difficult to discuss their emotions. Distress prevents optimal self-management, which may exacerbate flares, thereby creating a vicious cycle.To offer people novel way expressing personal models in order gain better understanding experiences living condition.We used qualitative technique - asking complete postcard entitled 'Dear Psoriasis...' collect survey data on...
Background There are limited data on the use of ustekinumab outside clinical trials. Objectives To assess efficacy and safety in patients with severe psoriasis attending 10 dermatology centres U.K. Ireland. Methods A retrospective case‐note review 129 treated ustekinumab. Results Baseline Psoriasis Area Severity Index (PASI) was 22·9 ± 10·1 (mean SD). After 16 weeks treatment PASI 75 (75% reduction PASI) observed 63·0% (n = 80/127) patients, although four required concomitant therapy at...
BackgroundFew studies have explored the immunology and genetic risk of paradoxical eczema occurring as an adverse event biologic therapy in patients with psoriasis.ObjectivesWe sought to describe systemic inflammatory signature using proteomics explore whether this is genetically mediated.MethodsThis study used Olink Target 96 Inflammation panel on 256 serum samples from 71 psoriasis eczema, 75 controls identify differentially expressed proteins enriched gene sets. Case 1 or more time points...
To determine an albino population's expectations from outreach clinic, understanding of skin cancer risk, and attitudes toward sun protection behavior.Survey, June 1, 1997, to September 30, 1997.Outreach clinics in Tanzania.All albinos 13 years older accompanying adults younger children attending clinics. Unaccompanied than those too sick answer questions were excluded. Ninety-four questionnaires completed 5 villages, with a 100% response rate.Interview-based questionnaire scoring system for...
The identification of robust endotypes-disease subgroups clinical relevance-is fundamental to stratified medicine. We hypothesized that HLA-C∗06:02 status, the major genetic determinant psoriasis, defines a psoriasis endotype relevance. Using two United Kingdom-based cross-sectional datasets-an observational severe-psoriasis study (Biomarkers Systemic Treatment Outcomes in Psoriasis; n = 3,767) and large population-based bioresource (UK Biobank, including 5,519 individuals with psoriasis)-we...
Psoriasis can adversely affect quality of life (QoL) and emotional well-being. In this UK prospective observational study we evaluated the 'real-world' impact adalimumab on QoL physical/psychological effects moderate-to-severe psoriasis. Hundred forty-three biologic-naïve patients with psoriasis, receiving in clinical practice, were included. Patients completed a series questionnaires at baseline (adalimumab initiation), 4 16-weeks 6-months post-adalimumab initiation during routine visits....
Targeted biologic therapies can elicit an undesirable host immune response characterized by the development of antidrug antibodies (ADA), important cause treatment failure. The most widely used across immune-mediated diseases is adalimumab, a tumor necrosis factor inhibitor. This study aimed to identify genetic variants that contribute ADA against thereby influencing In patients with psoriasis on their first course in whom serum had been evaluated 6-36 months after starting treatment, we...
Regulation of cell cycle progression is a fundamental control process, linked to cellular differentiation and apoptosis in normal tissues. p21(WAF1) nuclear protein that regulates progression. can be transcriptionally upregulated by p53, but may activated independently p53-for example, during terminal differentiation. Loss topological expression an early feature malignancy the colorectal system. Similar colonic mucosa, sebaceous glands contain cells are constantly going through process...
Background Recent concerns over the side‐effects of psoralen plus ultraviolet (UV) A, immunosuppressive and cytotoxic treatments have led to increased interest in dithranol for treatment psoriasis. Few studies investigated how frequently should be applied. Dithranol‐induced inflammation is maximal at 48–72 h, suggesting that daily application may not optimal. Objectives To investigate effectiveness five times weekly short‐contact (SCD) compared with three a dedicated hospital outpatient...
screening to detect breast cancer, 2 such that the increase in false positive recall is not offset by improved cancer detection.Our finding effect of hormone replacement therapy takes several years wear off does support suggestions high rates current users could be largely reversed if women ceased use hormones weeks or months before mammography.We thank many who completed questionnaires for this study.We are grateful staff at collaborating units and Million Women Study coordinating centre...
Psoriasis is a long-term inflammatory skin disorder, with negative effects on employment, relationships and social function, frequently causing reduced quality of life. People psoriasis often present to secondary care late into their condition but the reasons for this are unknown.To examine patient pathway, health-seeking behaviour drivers referral in patients psoriasis.Sixteen mild-to-severe psoriasis, newly referred participated semi-structured interview. Scripts were analysed by thematic...
Blistering is not a feature normally associated with mycosis fungoides (MF). We present case of MF in which histopathological vesicle formation was such prominent that diagnosis delayed. The patient's disease ran an aggressive course and death occurred within one year presentation. Tumour involvement the tongue unusual late feature.
Certolizumab pegol (CZP) is an Fc-free, PEGylated, anti-tumour necrosis factor biologic. Safety and efficacy data for CZP over 3 years have been previously reported. We report 3-year quality of life (QoL) outcomes patients treated with CZP, pooled from two phase trials.
Journal Article Atypical cutaneous leishmaniasis in two patients receiving low‐dose methotrexate Get access M. Saha, Saha Department of Dermatology, Royal Free Hospital, London, U.K. *Department Bristol Infirmary, Bristol, †University College London Hospitals NHS Trust, School Hygiene and Tropical Medicine, U.K Monika Saha. E‐mail: monikasaha@doctors.net.uk Search for other works by this author on: Oxford Academic Google Scholar D. Shipley, Shipley S. McBride, McBride C. Kennedy, Kennedy F....
Abstract not available. Disclosures: Study supported by Celgene. Copyright SKIN 2018