A5046099410- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- melanin and skin pigmentation
- Contact Dermatitis and Allergies
- Occupational exposure and asthma
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Drug-Induced Adverse Reactions
- Skin Protection and Aging
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Polyamine Metabolism and Applications
- Antimicrobial agents and applications
- Medicinal plant effects and applications
- Autoimmune and Inflammatory Disorders
- Chemotherapy-related skin toxicity
- Transgenic Plants and Applications
- Biochemical Analysis and Sensing Techniques
- COVID-19 and healthcare impacts
- Eosinophilic Esophagitis
- Mast cells and histamine
Bedford Hospital NHS Trust
2013-2023
Bedford Hospital
1999-2022
Sechenov University
2018-2019
Moscow State University of Food Production
2018
Ministry of Health of the Russian Federation
1998
Russian Cancer Research Center NN Blokhin
1998
Academy of Medical Sciences
1998
St Thomas' Hospital
1997
Biologic therapies for psoriasis can cause paradoxical eczema. The role of genetic factors in its pathogenesis is unknown. To identify risk variants, we conducted a GWAS 3,212 patients with psoriasis, whom 88 developed Two lead SNPs reached genome-wide significance (P ≤ 5 × 10−8) association eczema: rs192705221 (near UNC5B, P = 9.52 10−10) and rs72925168 (within SLC1A2, 1.66 10−9). Genome-wide significant from published were used to generate polygenic scores (PRSs) atopic eczema, general...
BackgroundFew studies have explored the immunology and genetic risk of paradoxical eczema occurring as an adverse event biologic therapy in patients with psoriasis.ObjectivesWe sought to describe systemic inflammatory signature using proteomics explore whether this is genetically mediated.MethodsThis study used Olink Target 96 Inflammation panel on 256 serum samples from 71 psoriasis eczema, 75 controls identify differentially expressed proteins enriched gene sets. Case 1 or more time points...
Abstract Flushing can occur as a physiological response or may indicate an underlying condition, such carcinoid syndrome, mastocytosis rosacea. The mechanisms and causes of flushing are discussed. Learning objective At the conclusion this learning activity, participants should be able to describe pathogenesis clinical characteristics aware modalities diagnose treat common dermatological sign.
Vitiligo is one of the most common hypomelanoses. Current treatments include ultraviolet, topical corticosteroids, calcineurin inhibitors. Orally administered vitamins, acting as anti-oxidants and in combination with ultraviolet light have also demonstrated skin re-pigmentation. In our pilot study seven patients, we injected affected vitiligo intra-dermally a complex vitamins minerals assessed outcome.The aim this was to evaluate novel treatment modality for vitiligo.We present patients;...
Dicaprylyl maleate (DCM) has been reported rarely as a cause of allergic contact dermatitis. The objectives this study were to identify patients from multiple centres with allergy DCM in cosmetic products confirmed by patch testing and, addition, investigate the effect aged DCM. This is an international multicentre 22 26 reactions containing Patch was carried out ingredients including obtained manufacturer. Further deliberately sample patients. had clinical and positive test at 4 days total...
Key content Pregnancy results in various physiological skin changes. As a consequence, some common dermatoses can present more frequently pregnant women. In addition, there are number of eruptions unique to pregnancy. The aetiology changes pregnancy is uncertain but thought be due hormonal and physical four are: atopic eruption pregnancy, pemphigoid gestationis, polymorphic intrahepatic cholestasis Learning objectives To understand the identify conditions that require appropriate referral....
Although telemedicine emerged more than 100 years ago, the recent pandemic underlined role of remote assessment different diseases. The diagnoses cutaneous conditions, especially malignant lesions, have placed significant stress on fast-track pathway for general practitioners (GPs), dermatologists, and plastic surgeons. aim study was to compare (pre- during pandemic) ability professionals face challenge. composed 1943 consecutive patients (mean age 61.9 ± 18.3, 53.8% female) assessed by GPs,...
Background. Rhinophyma is a chronic and progressive condition, considered form of severe rosacea, which classically affects the tip nose. Some people have rhinophyma without having rosacea. The disease also carries risk 3-10% malignant transformation. Different therapeutic methods been described over time, with different grades efficiency, each them its associated risks. At present, gold standard treatment for "established" ablative laser Aim. To propose new protocol, combining non-ablative...