A5026928834- Psoriasis: Treatment and Pathogenesis
- Acute Myocardial Infarction Research
- Dermatology and Skin Diseases
- Musculoskeletal pain and rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Osteoarthritis Treatment and Mechanisms
- Pain Mechanisms and Treatments
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Asthma and respiratory diseases
- Pediatric Pain Management Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Coronary Interventions and Diagnostics
- Empathy and Medical Education
- Total Knee Arthroplasty Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Musculoskeletal synovial abnormalities and treatments
- Pain Management and Placebo Effect
- Lower Extremity Biomechanics and Pathologies
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
University of Manchester
2021-2025
NIHR Manchester Biomedical Research Centre
2023
Manchester University NHS Foundation Trust
2023
Manchester Academic Health Science Centre
2023
University of Leeds
2013-2021
NIHR Leeds Musculoskeletal Biomedical Research Unit
2019-2021
Leeds Teaching Hospitals NHS Trust
2020
Medical Research Council
2017
Leeds Beckett University
2010-2016
Sirte University
2010
This study assessed sex differences in treatments, all-cause mortality, relative survival, and excess mortality following acute myocardial infarction.A population-based cohort of all hospitals providing infarction care Sweden (SWEDEHEART [Swedish Web System for Enhancement Development Evidence-Based Care Heart Disease Evaluated According to Recommended Therapies]) from 2003 2013 was included the analysis. Excess rate ratios (EMRRs), adjusted clinical characteristics guideline-indicated...
Drug survival of biologic therapies for psoriasis is a proxy longer-term treatment effectiveness and safety. Patient factors that are associated with the each differently (effect modifiers) may inform decision to choose between biologics.To assess drug safety commonly used biologics in UK Ireland identify effect modifiers these their survival.We conducted prospective cohort study patients using data from British Association Dermatologists Biologics Immunomodulators Register (BADBIR) November...
Objectives Osteoarthritis (OA) structural status is imperfectly classified using radiographic assessment. Statistical shape modelling (SSM), a form of machine-learning, provides precise quantification characteristic 3D OA bone shape. We aimed to determine the benefits this novel measure for assessing risks clinically important outcomes. Methods The study used 4796 individuals from Initiative cohort. SSM-derived femur (B-score) was measured all 9433 baseline knee MRIs. examined relationship...
Importance Biologics used for plaque psoriasis have been reported to be associated with an atopic dermatitis (AD) phenotype, or paradoxical eczema, in some patients. The risk factors this are unknown. Objective To explore of eczema by biologic class and identify eczema. Design, Setting, Participants This prospective cohort study data from the British Association Dermatologists Immunomodulators Register adults treated biologics who were seen at multicenter dermatology clinics UK Ireland....
Aim To define trajectories of perceived health-related quality life (HRQoL) among survivors acute myocardial infarction (AMI) and identify factors associated with trajectories. Methods Data on HRQoL 9566 AMI were collected from 77 National Health Service hospitals in England between 1 November 2011 24 June 2015. Longitudinal was using the EuroQol five-dimension questionnaire measured at hospitalisation, 1, 6 12 months post-AMI. Trajectories post-MI determined multilevel regression analysis...
Background The long-term excess risk of death associated with diabetes following acute myocardial infarction is unknown. We determined the among patients ST-elevation (STEMI) and non-STEMI (NSTEMI) after adjustment for comorbidity, factors cardiovascular treatments. Methods Nationwide population-based cohort (STEMI n=281 259 NSTEMI n=422 661) using data from UK registry, MINAP, between 1 January 2003 30 June 2013. Age, sex, calendar year country-specific mortality rates populace England...
Adherence to guideline-indicated care for the treatment of non-ST-elevation myocardial infarction (NSTEMI) is associated with improved outcomes. We investigated extent and consequences non-adherence across a national health system. A cohort study (ClinicalTrials.gov identifier: NCT02436187) was conducted using data from Myocardial Ischaemia National Audit Project (n = 389,057 NSTEMI, n 247 hospitals, England Wales, 2003–2013). Accelerated failure time models were used quantify impact on...
Abstract Aims To compare ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) mortality between Sweden the UK, adjusting for background population rates of expected death, case mix, treatments. Methods results National data were collected from hospitals in [n = 73 hospitals, 180 368 patients, Swedish Web-system Enhancement Development Evidence-based care Heart disease Evaluated According to Recommended Therapies (SWEDEHEART)] UK 247, 662 529 Myocardial Ischaemia Audit...
To characterise the impact of dactylitis in disease-modifying antirheumatic drug (DMARD)-naive early psoriatic arthritis (PsA).Patients with PsA meeting classification criteria for (CASPAR) were recruited. Clinical outcomes recorded, and ultrasonography was conducted to assess grey scale (GS) power Doppler (PD) synovitis, periarticular cortical bone erosions enthesitis. The cohort dichotomised by presence or absence dactylitis.Of 177 patients PsA, those (dactylitic (81/177, 46%)) had higher...
Real-world data evaluating effectiveness and persistence of systemic therapies for patients with psoriasis are limited. Objectives To determine the acitretin, ciclosporin, fumaric acid esters (FAEs) methotrexate in moderate-to-severe psoriasis.Data from British Association Dermatologists Biologics Immunomodulators Register (BADBIR), a prospective, multicentre pharmacovigilance register receiving biologic and/or conventional therapies, were analysed. Eligible ≥ 16 years age first course FAEs...
Abstract Background The current management of psoriasis does not differentiate between young and old patients in selecting the safest and/or most effective biologic. Objectives To explore effect age at treatment initiation response to biologics with moderate-to-severe UK Eire. Methods Data from registering British Association Dermatologists Biologics Immunomodulators Register (BADBIR) 2007-2024 on first course Tumour Necrosis Factor (TNF), interleukin (IL) 12/13, IL-17 IL-23 inhibitors (i)...
Background: recent studies report an age-dependent decline in mortality after acute myocardial infarction (AMI). Objective: to investigate improvements survival hospitalisation with AMI. Design: population-based cohort study using data from the Myocardial Ischaemia National Audit Project. Subjects: a total of 583,466 patients AMI admitted 247 hospitals between 1 January 2003 and 31 December 2010. Methods: six-month relative (RS) was calculated ratio observed expected age-, sex- biennial...
Primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction (STEMI) is insufficiently implemented in many countries. We investigated patient and hospital characteristics associated with PPCI utilisation.Whole country registry data (MINAP, Myocardial Ischaemia National Audit Project) comprising PPCI-capable Health Service trusts England (84 trusts; 92 350 hospitalisations; 90 489 patients), 2003-2013. Multilevel Poisson regression modelled the relationship between...
BackgroundFew studies have explored the immunology and genetic risk of paradoxical eczema occurring as an adverse event biologic therapy in patients with psoriasis.ObjectivesWe sought to describe systemic inflammatory signature using proteomics explore whether this is genetically mediated.MethodsThis study used Olink Target 96 Inflammation panel on 256 serum samples from 71 psoriasis eczema, 75 controls identify differentially expressed proteins enriched gene sets. Case 1 or more time points...
Gender role expectations of pain (GREP) have been shown to mediate sex differences in experimental pain. Few studies investigated the ethnicity shaping GREP. The aim this study was examine interactions between and GREP on experimentally induced pressure ischaemic Libyan white British students their respective countries.Libyan (n = 124) 51) completed a questionnaire response measured. Blunt threshold (PPT) measured over 1st interosseous muscle using algometry. Pain intensity unpleasantness...
Objectives To investigate geographic variation in guideline-indicated treatments for non-ST-elevation myocardial infarction (NSTEMI) the English National Health Service (NHS). Design Cohort study using registry data from Myocardial Ischaemia Audit Project. Setting All Clinical Commissioning Groups (CCGs) (n=211) NHS. Participants 357 228 patients with NSTEMI between 1 January 2003 and 30 June 2013. Main outcome measure Proportion of eligible who received all (optimal care) according to date...
The identification of robust endotypes-disease subgroups clinical relevance-is fundamental to stratified medicine. We hypothesized that HLA-C∗06:02 status, the major genetic determinant psoriasis, defines a psoriasis endotype relevance. Using two United Kingdom-based cross-sectional datasets-an observational severe-psoriasis study (Biomarkers Systemic Treatment Outcomes in Psoriasis; n = 3,767) and large population-based bioresource (UK Biobank, including 5,519 individuals with psoriasis)-we...
Abstract Previous studies found a relationship between response to experimentally‐induced pain and scores for the gender role expectations of ( GREP ) questionnaire. Findings were similar in individuals from A merica, P ortugal I srael suggesting that may be universal. The aim this study was translate validate rabic using F actor nalysis investigate if sex differences cold‐pressor healthy L ibyan men women are mediated through stereotypical social constructs and/or pain‐related anxiety. One...
Background Transcatheter aortic valve implantation ( TAVI ) is indicated for patients with stenosis who are intermediate‐high surgical risk. Although all‐cause mortality rates after established, survival attributable to the procedure unclear because of competing causes mortality. The aim was report relative RS , which accounts background risks in a matched general population. Methods and Results National cohort data (n=6420) from 2007 2014 UK registry were by age, sex, year England Wales...
High survival rates are commonly reported following primary percutaneous coronary intervention for ST-elevation myocardial infarction, with most contemporary studies reporting overall survival.The aim of this study was to describe infarction corrected non-cardiovascular deaths by relative and investigate clinically significant factors associated poor long-term outcomes.Using the prospective UK Percutaneous Coronary Intervention registry, cases ( n=88,188; 2005-2013) were matched mortality...
Few studies have used real-world data to investigate the association between biologic therapy survival and age at psoriasis onset or HLA-C*06:02 status in patients with moderate-to-severe psoriasis. The robustness of these is limited by small sample size, short follow-up diverse safety effectiveness measures.
Survival after non-ST-elevation myocardial infarction (NSTEMI) is high and non-cardiovascular death has become more frequent. Observational studies typically quantify quality of care clinical outcomes using all-cause mortality, which nowadays may not reflect the impact index NSTEMI. We review investigate relative survival for quantifying longer term National cohort study hospitalized NSTEMI (Myocardial Ischaemia Audit Project; patients: n = 346 546, hospitals: 243, countries: England Wales)....