A5101400592- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Advanced Control Systems Optimization
- Allergic Rhinitis and Sensitization
- Fault Detection and Control Systems
- Cutaneous Melanoma Detection and Management
- Knowledge Management and Sharing
- Advanced Statistical Process Monitoring
- IL-33, ST2, and ILC Pathways
- Immunodeficiency and Autoimmune Disorders
- Technology Adoption and User Behaviour
- Autoimmune Bullous Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Genomics and Chromatin Dynamics
- Mast cells and histamine
- Garlic and Onion Studies
- Tattoo and Body Piercing Complications
- Monoclonal and Polyclonal Antibodies Research
- Nail Diseases and Treatments
- Eosinophilic Disorders and Syndromes
- Acne and Rosacea Treatments and Effects
- Biosimilars and Bioanalytical Methods
- Management and Marketing Education
St. Luke's Hospital
2014-2024
Bradford Teaching Hospitals NHS Foundation Trust
2018-2024
University of Bradford
2018-2024
St Luke's Hospital
2024
NIHR Manchester Biomedical Research Centre
2023
Manchester Academic Health Science Centre
2023
Versus Arthritis
2023
University of Manchester
2023
St Lukes Hospital
2020
University of Louisville
1991-2019
The term pustular psoriasis indicates a group of severe skin disorders characterized by eruptions neutrophil-filled pustules. disease, which often manifests with concurrent vulgaris, can have an acute systemic (generalized [GPP]) or chronic localized (palmoplantar pustulosis [PPP] and acrodermatitis continua Hallopeau [ACH]) presentation. Although mutations been uncovered in IL36RN AP1S3, the rarity disease has hindered study genotype-phenotype correlations.We sought to characterize clinical...
The identification of disease alleles underlying human autoinflammatory diseases can provide important insights into the mechanisms that maintain neutrophil homeostasis. Here, we focused our attention on generalized pustular psoriasis (GPP), a potentially life-threatening disorder presenting with cutaneous and systemic neutrophilia. Following whole-exome sequencing 19 unrelated affected individuals, identified subject harboring homozygous splice-site mutation (c.2031-2A>C) in MPO. This...
In a group of 612 consecutive patients undergoing routine patch tests for suspected allergic contact dermatitis, more than four-fifths the 364 women had their ears pierced, over half gave history cutaneous reactions to metallic jewelery and almost one-third were sensitive nickel. The increase in frequency nickel sensitivity with pierced compared those unpierced was highly significant (P less 0.001). men, much frequent; occupational factors often implicated few cases related ear piercing....
Abstract Nucleolar organizer regions (NORs) can be stained by a simple one‐step silver technique; the black dots formed are termed AgNORs. Often AgNORs tightly clustered, appearing as one silver‐stained nucleolus (AgNu). We have assessed this technique possible prognostic indicator for thick (> 3·0 mm) primary cutaneous malignant melanoma (CMM). Three groups were studied: (A) seven CMM that had not metastasized 8–20 years after excision; (B) three developed metastases 6–9 and (C) twelve...
High-cost biologic therapies have transformed the management of immune-mediated inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by measurement circulating drug levels has been shown to be effective in various settings. However, limited evidence exists for this approach with interleukin 12 23 inhibitor ustekinumab.To evaluate clinical utility therapeutic monitoring ustekinumab patients psoriasis.A prospective observational cohort 491 adults psoriasis was...
Palmoplantar pustulosis (PPP) is a rare, debilitating, chronic inflammatory skin disease that affects the hands and feet. Clinical, immunological genetic findings suggest pathogenic role for interleukin (IL)-1.
Although palmoplantar pustulosis (PPP) can significantly impact quality of life, the factors underlying disease severity have not been studied.To examine associated with PPP severity.An observational, cross-sectional study 2 cohorts was conducted. A UK data set including 203 patients obtained through Anakinra in Pustular Psoriasis, Response a Controlled Trial (2016-2019) and its sister research Elucidating Underlying Mechanisms (2016-2020). Northern European cohort 193 independently...
Robot safety is a critical and largely unsolved problem involving the interaction of man machine. The paper presents new approach to robot which uses an integrated sensing architecture for monitoring workspace, detection decision logic regulating safe operation robot. Sensory information fused through trained neural network produce map hazards. Using this combined map, about robot's current position velocity, set fuzzy rules has been implemented regulate activity. Simulation results...
An 82-year-old male with chronic lymphocytic leukaemia developed an erythematous papular eruption over the trunk. Lesions occurred at site of scars related to a disseminated herpes zoster infection 3 months previously. Biopsy lesion showed granuloma formation. The rash resolved spontaneously 6–8 weeks.
Nucleolar organiser regions (NORs) are loops of DNA situated on the short arms acrocentric chromosomes 13, 14, 15, 21, and 22; they can be demonstrated in formalin-fixed paraffin-embedded sections by a one-step silver technique, resulting black structures being termed AgNORs. We have applied technique to 30 benign “banal” nevi (BN), dysplastic (DN), malignant melanomas (MM). AgNORs 200 nuclei were scored means calculated. Counts as follows: BN showed mean 1.3 per nucleus within range...
An unusual case of extensive reticulate pigmentation due to bleomycin is reported. Light- and electron-microscopic studies showed a marked increase melanin pigment in the basal keratinocytes number melanophages upper dermis. The melanocytes appeared be normal. Electron microscopy also revealed damage subcellular organelles. thought consequence this focal damage.
Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation drug exposure. Real‐world psoriasis data were used develop a pharmacokinetic/pharmacodynamic (PK/PD) model the first‐line therapeutic antibody ustekinumab. The impact of differing dosing strategies on was explored. Data collected from UK prospective multicenter observational cohort (491 patients ustekinumab monotherapy, levels, and anti‐drug measurements 797 serum samples,...
Psoriasis is a multi-factorial immune-mediated disease that affects approximately 2% of the UK population and 2.5% worldwide. The condition can impact multiple organs, including skin joints. In moderate to severe cases, systemic topical medications may not provide adequate relief, as result, biologic treatments are often administered monotherapy or in combination with other treatments. While more effective than treating psoriasis, patients require close supervision monitoring while receiving...
Over the past few years, most universities in United States have been experimenting with use of different Internet technologies to support their educational programs. It is widely believed that these will play an increasingly imp
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Sodium cromoglicate (SCG) chromone with anti-inflammatory, anti-itch and anti-allergic activity. This trial 12-week comparison (RCT) of 4% SCG cutaneous emulsion its vehicle in AD.208 children aged 2-12 years participated, 104 each group. The primary endpoint was change SCORAD score. Secondary endpoints included SASSAD score, topical steroid usage global assessments.SCORAD reduced by 28% (SCG group) 19% (vehicle): difference...
212 epitheliomata developed in two unrelated women with self-healing of Ferguson-Smith. Most the lesions appear on face, often crops; they enlarge over 4 weeks and, without treatment, resolve months to leave a ragged scar. One patients an unusual syringoma, papillary carcinoma thyroid and mucosal squamous cell which failed involute spontaneously. Cytogenetic studies did not reveal any abnormality DNA repair. Surgical excision is successful but time consuming. X-irradiation should be used,...
Sunscreens are in widespread use as a form of skin protection against solar ultraviolet radiation. Previous studies provide some data to show that the amount sunscreen applied is less than manufacturers' recommendations, although have often used indirect measurement techniques. This study comprised 50 volunteers who standard aqueous cream hypoallergenic analogue for one their forearms. Two novel methods directly measuring forearm area were used, based on mathematical model and helically...
ABSTRACT Background Palmoplantar pustulosis (PPP) is an inflammatory skin disorder that mostly affects smokers and manifests with painful pustular eruptions on the palms soles. While disease can present concurrent plaque psoriasis, TNF IL-17/IL-23 inhibitors show limited efficacy. There therefore a pressing need to uncover PPP drivers therapeutic targets. Objectives To identify genetic determinants of investigate whether cigarette smoking contributes pathogenesis. Methods We performed...
Article Free Access Share on End user computing levels, job motivation and perceptions of outcomes: a field investigation Authors: Robert M. Barker Computer Information Systems, College Business Public Administration, University Louisville, Kentucky KentuckyView Profile , Andrew L. Wright Authors Info & Claims SIGCPR '97: Proceedings the 1997 ACM conference personnel researchApril Pages 224–233https://doi.org/10.1145/268820.268888Published:03 April 1997Publication History...
Public safety and cybersecurity are integrated endeavors as pervasive computing puts interconnected devices everywhere. STEM training in cyber security might occur within the traditional public framework, both of criminological study practical implementation. We tested responsiveness to for law enforcement from this perspective. Our findings suggest great potential group expanding effective protections communities through education. They further a commensurate need support realize potential.