A5030454539- Poetry Analysis and Criticism
- Autopsy Techniques and Outcomes
- Colorectal Cancer Screening and Detection
- Hepatitis C virus research
- Hepatitis B Virus Studies
- AI in cancer detection
- Infectious Diseases and Mycology
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Healthcare cost, quality, practices
- Mycobacterium research and diagnosis
- Planetary Science and Exploration
- Lymphadenopathy Diagnosis and Analysis
- Cancer Genomics and Diagnostics
- American Literature and Culture
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Aerospace Engineering and Energy Systems
- Liver Disease and Transplantation
- Astro and Planetary Science
- Sarcoma Diagnosis and Treatment
- Plant Disease Resistance and Genetics
- Estrogen and related hormone effects
- Hemophilia Treatment and Research
- Spacecraft Dynamics and Control
Yale University
2021
University of Sheffield
2000-2019
Jensen Hughes (United States)
2017-2018
Institute of History and Archaeology
2018
Henry Ford Hospital
2017
University of Hull
2014-2016
Lankenau Institute for Medical Research
2008
Phoebe Putney Memorial Hospital
2006
Tulane University
2003
Pennsylvania State University
2001
Angiogenesis is essential to the growth and metastasis of solid tumours. Vascular endothelial factor (VEGF) a potent pro-angiogenic cytokine that overexpressed in malignant tumours such as invasive carcinoma breast. The low oxygen tensions (hypoxia) present these are known up-regulate expression VEGF by tumour cells. Human macrophages also respond hypoxia increasing their release vitro, although effect on vivo has yet be demonstrated. study compared areas high vascularity 24 breast...
Abstract Silver‐binding nucleolar organizer regions (AgNORs) have been counted in sections of routinely processed paraffin‐embedded tissue blocks and shown to assist the distinction between benign malignant lesions. We examined 214 breast lesions by this method. The AgNOR counts were fibroadenomas 1.87 + 0.20 (mean SD; n = 39), papillomas 1.92 0.21 (n 28), sclerosing adenosis 1.96 0.24 23), epitheliosis 2.21 0.30 38), lobular carcinoma situ 2.67 0.54 =9), intraduct 3.75 1.33 37), invasive...
Biochemical remission is widely considered a satisfactory treatment end point in autoimmune hepatitis (AIH). The significance of persisting histological activity despite biochemical unknown. We aimed to assess the frequency and prognostic inflammation patients with AIH who had achieved treatment.We studied 120 (median age at diagnosis 57 years; 81% female) by International Criteria (59% definite), received immunosuppressive underwent follow-up liver biopsy after least 6 months sustained...
The frequencies of HLA class I antigens and II haplotypes were compared in subjects with previous (polymerase chain reaction [PCR]-negative) or persistent (PCR-positive) hepatitis C virus (HCV) infection HCV patients mild versus severe histologic activity scores on liver biopsy. DRB1*11 allele group was found 11 (31.4%) 35 (8.2%) 135 (P < .001). DQB1*0301 18 (51.4%) 33 (24.4%) .002). Both observations remained significant after correction for multiple testing. No association shown between...
Abstract Nucleolar organizer regions (NORs) can be stained by a simple one‐step silver technique; the black dots formed are termed AgNORs. Often AgNORs tightly clustered, appearing as one silver‐stained nucleolus (AgNu). We have assessed this technique possible prognostic indicator for thick (> 3·0 mm) primary cutaneous malignant melanoma (CMM). Three groups were studied: (A) seven CMM that had not metastasized 8–20 years after excision; (B) three developed metastases 6–9 and (C) twelve...
To determine whether the renal arterial system has a fractal structure, dimension of angiograms from 52 necropsy cases was measured using an implementation box-counting method on image analysis system. The validated objects with known dimensions. accurate errors less than 1.5 per cent and reproducible initial values within 1.2 mean ten sets measurements (reliability coefficient 0.968, 95 confidence limits 0.911-0.984). In 36 satisfactory 1.61 (SD 0.06), which significantly greater...
The trends in necropsy rates during the 1980s three groups of British teaching hospitals Leicester, Manchester, and Sheffield were compared a retrospective study. clinical declined all cities: from 16 to 10 per cent; 14 8 18 11 cent. medico-legal overall showed variable between cities. Specific events changes organization review period correlated with changing trends. observed emphasize continued decline over last decade illustrate importance monitoring differential rates.
Sixty slides from 60 blocks taken 30 colonic carcinomas were circulated twice to six histopathologists of varying experience. Five the pathologists showed a good excellent intraobserver agreement for assessment character invasive margin (0.44 less than kappa 0.82), which was not significantly affected by sampling (0.40 0.56, comparing both each tumour) or observer (five agreeing on 46 slides). Pathologists unreliable in assessing peritumoural lymphocytic infiltrates, with only two achieving...