A5028959207- Psoriasis: Treatment and Pathogenesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytokine Signaling Pathways and Interactions
- Fungal and yeast genetics research
- RNA and protein synthesis mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Bioinformatics and Genomic Networks
- Eosinophilic Disorders and Syndromes
- Medical and Biological Ozone Research
- Microbial Metabolic Engineering and Bioproduction
- Bacterial Genetics and Biotechnology
- Dermatology and Skin Diseases
- Antifungal resistance and susceptibility
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
St John's Hospital
2020
King's College London
2018-2020
University of Cambridge
2017-2019
Psoriasis is an immune-mediated skin disorder associated with severe systemic comorbidities. Whereas IL-36 a key disease driver, the pathogenic role of this cytokine has mainly been investigated in skin. Thus, its effects on immunity and extracutaneous manifestations remain poorly understood. To address issue, we consequences excessive activity circulating immune cells. We initially focused our attention generalized pustular psoriasis (GPP), clinical variant pervasive upregulation signaling....
The identification of disease alleles underlying human autoinflammatory diseases can provide important insights into the mechanisms that maintain neutrophil homeostasis. Here, we focused our attention on generalized pustular psoriasis (GPP), a potentially life-threatening disorder presenting with cutaneous and systemic neutrophilia. Following whole-exome sequencing 19 unrelated affected individuals, identified subject harboring homozygous splice-site mutation (c.2031-2A>C) in MPO. This...
ABSTRACT We have engineered Saccharomyces cerevisiae to inducibly synthesize the prokaryotic signaling nucleotides cyclic di-GMP (cdiGMP), cdiAMP, and ppGpp in order characterize range of effects these exert on eukaryotic cell function during bacterial pathogenesis. Synthetic genetic array (SGA) transcriptome analyses indicated that, while compounds elicit some common reactions yeast, there are also complex distinctive responses each three nucleotides. All capable inhibiting growth, with...
This paper investigates whether, independently of the supply any specific nutrient, gene transcription responds to energy status cell by monitoring ATP and GTP levels. Short pathways for inducible futile consumption or were engineered into yeast Saccharomyces cerevisiae , effect an increased demand these purine nucleotides on was analyzed. The resulting changes in most consistently associated with GEC levels, although reprogramming expression during glucose repression is sensitive adenine...
Psoriasis is an immune-mediated skin disorder associated with severe systemic co-morbidities. Both chronic and acute forms of the disease are characterised by abnormal interleukin (IL)-36 signalling. While mechanisms whereby IL-36 promotes cutaneous inflammation well established, its effects have not been investigated. To address this issue, we initially measured leukocyte gene expression in generalised pustular psoriasis, variant caused mutations receptor antagonist. By undertaking...
Abstract The identification of disease alleles underlying human autoinflammatory diseases can provide important insights into the mechanisms that maintain neutrophil homeostasis. Here, we focused on generalized pustular psoriasis (GPP), a potentially life-threatening disorder presenting with cutaneous and systemic neutrophilia. Following whole exome sequencing 19 unrelated cases, identified one affected individual harbouring homozygous splice-site mutation (c.2031-2A>C) in MPO . same...